2010
DOI: 10.1016/j.jemermed.2008.03.032
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Emergent Complications of the Newer Anticonvulsants

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Cited by 38 publications
(18 citation statements)
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“…Patients with comorbid psychiatric conditions, headache, and neuropathic pain may also be treated with AEDs for which there are multiple indications for use (e.g., valproate for bipolar disorder and headache and topiramate for headache). Alternatively, some comorbid conditions may be negatively affected by certain AEDs, such as increased or reoccurring psychiatric symptoms after use of levetiracetam [4][5][6][7]. Finally, because of the potential for drug interactions and side effects in older patients, age should be considered when selecting AEDs (e.g., phenytoin and phenobarbital) [8].…”
Section: Introductionmentioning
confidence: 99%
“…Patients with comorbid psychiatric conditions, headache, and neuropathic pain may also be treated with AEDs for which there are multiple indications for use (e.g., valproate for bipolar disorder and headache and topiramate for headache). Alternatively, some comorbid conditions may be negatively affected by certain AEDs, such as increased or reoccurring psychiatric symptoms after use of levetiracetam [4][5][6][7]. Finally, because of the potential for drug interactions and side effects in older patients, age should be considered when selecting AEDs (e.g., phenytoin and phenobarbital) [8].…”
Section: Introductionmentioning
confidence: 99%
“…Seizures were not observed during the 7-day hospitalisation period, although exacerbation of seizure activity has been described in association with overdose of several AEDs, also with the newer drugs [21]. Presumably the patient had sufficient seizure protection by her medication with clobazam and lacosamide.…”
Section: Discussionmentioning
confidence: 93%
“…2,6,7 Lamotrigine exerts its antiepileptic effect through inhibition of voltage-gated sodium channels. 1 While the primary target is neuronal tissue, lamotrigine has the potential to block cardiac sodium channels as well.…”
Section: Discussionmentioning
confidence: 99%
“…Consequently, wide complex rhythms have been described, though infrequently, following lamotrigine use in both therapeutic 4 and overdoses. 2,7 Common symptoms following overdose include drowsiness, vomiting, nausea, ataxia, vertigo, and tachycardia. 2 Other reported complications include seizures, 6 anticonvulsant hypersensitivity syndrome, 3 respiratory depression, 7 and choreiform dyskinesia.…”
Section: Discussionmentioning
confidence: 99%