Antiepileptic drug prescribing patterns in Iraq and Afghanistan war veterans with epilepsy

Rohde, Natalie N.; Baca, Christine B.; Cott, Anne C. Van; Parko, Karen; Amuan, Megan E.; Pugh, Mary Jo

doi:10.1016/j.yebeh.2015.03.027

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…33,37 Our earlier finding of "rational polypharmacy" in post-9/11 veterans with epilepsy suggests this is common among veterans with epilepsy. 38 Figure 3 Likelihood of suicide-related behavior over time among antiepileptic drug (AED) users by type of AED received SRB risk declined significantly after the initiation of the treatment with mood-stabilizing AEDs, which is consistent with the study by Tsai et al, 39 which concluded that immediate or recent use of any mood stabilizer considerably lowers the rate of death, suicide, or suicidal behavior in bipolar disorder patients. The asymmetry of the SRB probability before and after the index date suggested a potential long-term effect of AED on SRB.…”

Section: Discussionsupporting

confidence: 75%

Antiepileptic drugs and suicide-related behavior

et al. 2018

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Section: Discussionsupporting

confidence: 75%

Antiepileptic drugs and suicide-related behavior

et al. 2018

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“…Epilepsy treatment is complex and may require multiple antiepileptic drugs, special diets, and neurostimulation [ 11 ]. Additionally, the use of antiepileptic drugs often leads to side effects and drug-drug interactions [ 12 , 13 ], which can result in poor patient adherence, especially among those with limited knowledge about the disease and its treatment [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Pharmacists’ Interventions in Increasing Medication Adherence of Patients With Epilepsy: A Scoping Review

Ernawati,

Munif Yasin,

Setyopranoto

et al. 2024

JPMPH

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Objectives: Epilepsy is a chronic disease that requires long-term treatment and intervention from health workers. Medication adherence is a factor that influences the success of therapy for patients with epilepsy. Therefore, this study aimed to analyze the role of pharmacists in improving the clinical outcomes of epilepsy patients, focusing on medication adherence.Methods: A scoping literature search was conducted through the ScienceDirect, PubMed, and Google Scholar databases. The literature search included all original articles published in English until August 2023 for which the full text was available. This scoping review was carried out by a team consisting of pharmacists and neurologists following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews and the Joanna Briggs Institute guidelines, including 5 steps: identifying research questions, finding relevant articles, selecting articles, presenting data, and compiling the results.Results: The literature search yielded 10 studies that discussed pharmacist interventions for patients with epilepsy. Five articles described educational interventions involving drug-related counseling with pharmacists. Two articles focused on similar pharmacist interventions through patient education, both verbal and written. Three articles discussed an epilepsy review service, a multidisciplinary intervention program involving pharmacists and other health workers, and a mixed intervention combining education and training with therapy-based behavioral interventions.Conclusions: Pharmacist interventions have been shown to be effective in improving medication adherence in patients with epilepsy. Furthermore, these interventions play a crucial role in improving other therapeutic outcomes, including patients’ knowledge of self-management, perceptions of illness, the efficacy of antiepileptic drugs in controlling seizures, and overall quality of life.

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“…For example, many patients are transitioned from older ASMs with greater adverse effects (AEs) to better tolerated newer generation ASMs or polytherapy regimens with complex pharmacokinetic profiles and drug interactions. 5 Multiple factors are considered when choosing an ASM, including age, sex, epilepsy/seizure type, comorbidities, past medication trials, AEs, and drug interactions. The complex pharmacologic profile of both older and newer ASMs can confound the optimal management of epilepsy, and suboptimal management can lead to neurologic, psychological, physical, and social consequences, including sudden un-explained death in epilepsy.…”

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confidence: 99%

Impact of Clinical Pharmacists on Access to Care in an Epilepsy Clinic

Taube¹

2022

Federal Practitioner

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Background: Epilepsy affects about 1% of the world population and is one of the most burdensome diseases in terms of disability-adjusted life-years. The demand for neurologists and epileptologists is expected to exceed current supply by 2025. One potential strategy to increase access to epilepsy care is to utilize clinical pharmacist practitioners (CPPs) with a broad scope of practice. Methods: Appointments at the William S. Middleton Memorial Veterans Hospital (WSMVH) epilepsy clinic in Madison, Wisconsin, were reviewed to determine the percentage of appointments completed by a CPP or clinical pharmacy resident from October 2019 to May 2021. Additionally, a retrospective chart review was completed on 446 veterans to identify the types of interventions made by a CPP or clinical pharmacy resident at each appointment from October 2017 to June 2021. Results: The CPP or clinical pharmacy resident held approximately 43% of 591 total appointments and spent a mean 27 minutes with each patient. Medication interventions occurred at 27% of 446 appointments in the retrospective chart review. Half (50.4%) of all patients seen by a CPP completed at least 1 mental health screening. Conclusion:The integration of a CPP WSMVH epilepsy clinic allowed for greater and more timely access to care and allowed for the epileptologists to focus their time on new consults, Epilepsy Monitoring Unit admissions, and higher acuity cases.

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Antiepileptic drug prescribing patterns in Iraq and Afghanistan war veterans with epilepsy

Cited by 4 publications

References 35 publications

Antiepileptic drugs and suicide-related behavior

Antiepileptic drugs and suicide-related behavior

The Role of Pharmacists’ Interventions in Increasing Medication Adherence of Patients With Epilepsy: A Scoping Review

Impact of Clinical Pharmacists on Access to Care in an Epilepsy Clinic

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