A 78-year-old woman with permanent atrial fibrillation was referred to our institution for percutaneous left atrial appendage (LAA) occlusion. The patient had a high thromboembolic risk based on a CHA2DS2-VASc score of 8 and was on oral anticoagulant therapy with rivaroxaban at a dose of 20 mg/d. Because of major postural instability, the patient experienced recurrent falls with subsequent large and disabling superficial hematomas. The HAS-BLED score was 4. The procedure was performed under general anesthesia and with transesophageal echocardiogram guidance. After transseptal puncture, a 5-Fr multipurpose catheter was used to engage and inject the LAA. The maximal diameter of the ostium and the landing zone of the LAA were measured at 22 and 25 mm using transesophageal echocardiogram ( Figure 1A) and at 22 and 21 mm using angiography ( Figure 1B). Based on these measurements, we estimated an average diameter of the landing zone of 23 mm and we decided to implant a 26-mm Amplatzer Cardiac Plug (ACP; St. Jude Medical).After device deployment, all criteria of correct implantation were checked. Adequate compression of the device lobe was noted with a good separation between the device lobe and the disc. The device lobe was aligned with the neck of the appendage (Figure 2A) and more than two third of the device lobe was located distal to the circumflex artery ( Figure 2B). Finally, we applied a slight tension on the delivery cable (wiggle test), which confirmed device stability ( Figure 2C). The ACP was then released by removing the delivery cable. The patient experienced no procedural complication and was discharged the following day after control transthoracic echocardiogram showing no pericardial effusion and the absence of device dislodgement. Dual antiplatelet therapy with aspirin and clopidogrel was given, and a transesophageal echocardiogram control was planned at 6 weeks. One month after the procedure, the patient was readmitted to our institution, out of working hours, for acute dyspnea at rest and severe hypotension. Chest radiograph disclosed major pulmonary edema, and (Circ Cardiovasc Interv. 2014;7:628-630.)