2001
DOI: 10.1016/s0168-8278(01)00065-4
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Emergence of YMDD motif mutant of hepatitis B virus during short-term lamivudine therapy in South Korea

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Cited by 33 publications
(34 citation statements)
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“…They did not show VBT during treatment period. But we might have missed VBT in these patients because the test for HBV DNA had not been tested at the right time, or YMDD mutants may have existed even before LAM monotherapy [18] . The experimental results from both direct sequencing and InnoLipa DR2 line probe assay were consistent in all patients.…”
Section: Peer Reviewmentioning
confidence: 99%
“…They did not show VBT during treatment period. But we might have missed VBT in these patients because the test for HBV DNA had not been tested at the right time, or YMDD mutants may have existed even before LAM monotherapy [18] . The experimental results from both direct sequencing and InnoLipa DR2 line probe assay were consistent in all patients.…”
Section: Peer Reviewmentioning
confidence: 99%
“…HBV isolates with mutations in the YMDD motif of the polymerase gene have been detected in patients who have received long-term lamivudine therapy (1,5,8,10,12). Mutants with either the YVDD or the YIDD mutation were detected in 14 to 47% of patients after 1 year of lamivudine therapy.…”
Section: Discussionmentioning
confidence: 99%
“…Mutants with either the YVDD or the YIDD mutation were detected in 14 to 47% of patients after 1 year of lamivudine therapy. Moreover, the mutants with YMDD mutations were detected as early as a few weeks (12 weeks) after the start of lamivudine therapy in Korea (12). Rapid and accurate detection of lamivudine-resistant HBV provides us with important information about therapies (13,17).…”
Section: Discussionmentioning
confidence: 99%
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