Emergence of vancomycin-intermediate Staphylococcus species in southern India

Menezes, Godfred Antony; Harish, Belgode Narasimha; Sujatha, S.; Vinothini, K.; Parija, Subhash Chandra

doi:10.1099/jmm.0.47829-0

Cited by 48 publications

(48 citation statements)

References 4 publications

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“…However, from northern India, Deep et al, had reported linezolid resistance in 9% MRSA [20]. Reports on reduced vancomycin sensitivities with borderline MICs are not uncommon nowadays [21,22]. Although, we found that all MRSA strains had MICs in sensitive range, [ Fig-4].…”

Section: Discussioncontrasting

confidence: 53%

Changing Trends in Resistance Pattern of Methicillin Resistant Staphylococcus aureus

Kali

Spellman²,

Umadevi³

et al. 2013

JCDR

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Background: Methicillin resistance in Staphylococcus aureus is associated with multidrug resistance, an aggressive course, increased mortality and morbidity in both community and health care facilities. Monitoring of newly emerging and prevalent Methicillin Resistant Staphylococcus aureus (MRSA) strains for their resistance patterns to conventional as well as novel drugs, are essential for infection control. Aims:To study the changing trends in resistance patterns of MRSA at our hospital. Settings and Design:This cross sectional study was carried out in a 750 bed tertiary care hospital in south India.

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Section: Discussioncontrasting

confidence: 53%

Changing Trends in Resistance Pattern of Methicillin Resistant Staphylococcus aureus

Kali

Spellman²,

Umadevi³

et al. 2013

JCDR

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“…It is now responsible for around 30% or more of all serious infections though this figure varies 10,18 . There is an increased chance to cause cross infection and MRSA also has the ability to colonize individuals for months and years.…”

Section: Discussionmentioning

confidence: 99%

“…Since then, there is a steady increase in the number of cases with VISA and VRSA. This has triggered of alarms in the medical community as S. aureus causes life threatening infections in the hospital as well as in the community.The predicted mechanism of van A gene plasmid-mediated transfer from enterococci to S. aureus was later observed for the first time in 5,9,10,11,12 . The study was undertaken to monitor the vancomycin susceptibility of MRSA from clinical samples in a tertiary care teaching hospital in Kolkata.…”

Section: Introductionmentioning

confidence: 99%

Vancomycin intermediate Staphylococcus aureus isolated from a tertiary care hospital in Kolkata

Bhattacharya¹

2013

IOSR-JDMS

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“…After the first reports of VISA and hVISA from Japan, it did not take long for this resistance phenotype to be recognized around the world. Strains of S. aureus (predominately MRSA) demonstrating the hVISA or VISA phenotype have now been reported for many countries including the United States, Japan, Australia, France, Scotland, Brazil, South Korea, Hong Kong, South Africa, Thailand, Israel, and others (22,67,69,77,79,82,94,158,167,194,195,206,258,284,300,326,327,331,352,354,366,373). A retrospective analysis of stored isolates detected previously unrecognized hVISA/VISA strains at least back to 1987 in the United States and back to a similar period in France, Spain, and Germany (11,22,39,276,288); however, there has been some concern about the potential loss of resistance during prolonged storage, which could impact results of such retrospective analyses.…”

Section: Global Epidemiology and Associated Features Of Hvisa And Visamentioning

confidence: 99%

Reduced Vancomycin Susceptibility inStaphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

et al. 2010

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SUMMARY The emergence of vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) over the past decade has provided a challenge to diagnostic microbiologists to detect these strains, clinicians treating patients with infections due to these strains, and researchers attempting to understand the resistance mechanisms. Recent data show that these strains have been detected globally and in many cases are associated with glycopeptide treatment failure; however, more rigorous clinical studies are required to clearly define the contribution of hVISA to glycopeptide treatment outcomes. It is now becoming clear that sequential point mutations in key global regulatory genes contribute to the hVISA and VISA phenotypes, which are associated predominately with cell wall thickening and restricted vancomycin access to its site of activity in the division septum; however, the phenotypic features of these strains can vary because the mutations leading to resistance can vary. Interestingly, changes in the staphylococcal surface and expression of agr are likely to impact host-pathogen interactions in hVISA and VISA infections. Given the subtleties of vancomycin susceptibility testing against S. aureus, it is imperative that diagnostic laboratories use well-standardized methods and have a framework for detecting reduced vancomycin susceptibility in S. aureus.

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Emergence of vancomycin-intermediate Staphylococcus species in southern India

Cited by 48 publications

References 4 publications

Changing Trends in Resistance Pattern of Methicillin Resistant Staphylococcus aureus

Changing Trends in Resistance Pattern of Methicillin Resistant Staphylococcus aureus

Vancomycin intermediate Staphylococcus aureus isolated from a tertiary care hospital in Kolkata

Reduced Vancomycin Susceptibility inStaphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

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