Emergence of Unusual G6P[6] Rotaviruses in Children, Burkina Faso, 2009–2010

Nordgren, Johan; Nitiema, Léon W.; Sharma, Sumit; Ouermi, Djénèba; Traoré, Alfred S.; Simporé, Jacques; Svensson, Lennart

doi:10.3201/eid1804.110973

Cited by 51 publications

(79 citation statements)

References 40 publications

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“…The genotype constellation of PML1965 was G6-P[6]-I2-R2-C2-M2-A2-N2-T2-E2-H2, which was identical with that of the prototype G6P [6] strain B1711 detected in Belgium (Matthijnssens et al, 2008a) as well as those of G6P [6] strains detected in Cameroon (Ndze et al, 2014) and Guinea Bissau (GenBank data) (Table 1). Furthermore, it appeared identical with the genotype constellation of G6P [6] strains detected in Burkina Faso (Nordgren et al, 2012a) and Italy (Ianiro et al, 2013), although the genotypes of genome segments 1, 2 and 3 were not available (Table 1).…”

Section: Genotype Constellation Of Pml1965mentioning

confidence: 54%

“…Subsequently, the VP7 genes of G6P [6] strains detected in Burkina Faso were speculated to derive from an interspecies transmission event of bovine rotavirus to humans because people live in close proximity with cattle in Burkina Faso, thereby increasing the chance of interspecies transmission (Nordgren et al, 2012a). However, Ianiro et al (2013) concluded that there was no evidence of zoonosis or interspecies reassortment after analysing eight genome segments of a G6P [6] strain detected in Italy in 2011.…”

Section: Discussionmentioning

confidence: 99%

“…Two distinct hypotheses were proposed to explain the evolutionary process by which these G6P [6] strains emerged. Whereas the G6P [6] strain detected in Italy was reported to lack any evidence of zoonotic transmission and was linked to interspecies reassortment (Ianiro et al, 2013), G6P [6] strains detected in Belgium and Burkina Faso were linked to interspecies transmission from cattle to humans (Matthijnssens et al, 2008a;Nordgren et al, 2012a). As we had an opportunity to analyse a G6P [6] strain, designated PML1965, detected in Ghana during the 2012 rotavirus surveillance period (Enweronu-Laryea et al, 2014), we carried out whole genome sequencing analysis of PML1965 in order to gain clues regarding the evolutionary process by which such G6P [6] strains emerged in Africa.…”

Section: Introductionmentioning

confidence: 99%

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Evolution of a G6P[6] rotavirus strain isolated from a child with acute gastroenteritis in Ghana, 2012

Agbemabiese

Nakagomi

Suzuki

et al. 2015

Journal of General Virology

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Unusual human G6P [6] rotavirus A (RVA) strains have been reported sporadically in Europe and Africa, but how they evolved was not fully understood. The whole genome of a Ghanaian G6P[6] strain designated PML1965 (2012) was analysed to understand how it evolved in Africa and to learn how its G6 VP7 gene was related to that of rotaviruses of human and artiodactyl origin. The genotype constellation of RVA/Human-wt/GHA/PML1965/2012/G6P[6] was G6-P-[6]-I2-R2-C2-M2-A2-N2-T2-E2-H2. It shared sublineages with G6P[6] strains previously detected in Italy and Africa in all genome segments except the VP6 gene of a few Burkinabe and Cameroonian strains and both the VP6 and NSP4 genes of Guinea Bissau strains. The VP7 gene of the G6P[6] strains appeared to derive from those of human G6P [9] strains, and they were distantly related to the VP7 genes of artiodactyl G6 or human G6P [14] strains. The time of the most recent common ancestor of the VP7 sequences of G6P[6] strains was estimated to be the year 1998. The evolutionary rates of the VP7 genes in bovine and human G6 rotaviruses were 6.93610 24 and 3.42610 23 nucleotide substitutions site 21 year 21 , respectively, suggesting an accelerated adaptive process in the new host. The sequences of the remaining 10 genome segments of PML1965 clustered with those of G2 and G8 human rotaviruses detected in Africa possessing the DS-1-like genetic background.In conclusion, PML1965 evolved from G2 or G8 RVA strains with DS-1-like background, acquiring the G6 VP7 gene from a human G6P[9] RVA and not from an artiodactyl G6 RVA strain.

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Section: Genotype Constellation Of Pml1965mentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evolution of a G6P[6] rotavirus strain isolated from a child with acute gastroenteritis in Ghana, 2012

Agbemabiese

Nakagomi

Suzuki

et al. 2015

Journal of General Virology

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“…The reasons for this are yet unknown, but a different and more diverse genetic setup of RVA strains could be one of the reasons. The RVA strain diversity in Africa is higher than from industrialized countries and also have a high degree of animal or animal derived genes (Nordgren et al, 2012;Todd et al, 2010). Some other major differences include the relatively high prevalence of the P[6] genotype as well as a high detection rate of G8 in certain countries (Armah et al, 2010;Nordgren et al, 2012;Page et al, 2010b;Todd et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Rotavirus in diarrheal children in rural Burkina Faso: High prevalence of genotype G6P[6]

Nordgren

Bonkoungou

Nitiema

et al. 2012

Infection, Genetics and Evolution

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“…G6P [14] in Egypt [22] and G6P [9] in Burkina Faso [23] in either was reported as a rare virus. Case 24 in this study without previous contact with obvious bovine did not identify the source of infection.…”

Section: Discussionmentioning

confidence: 99%

A Study on the Origin of Bovine Rotavirus Strains Detected from the Children of the Nasu District, Tochigi, Japan

Numazaki¹,

Ichikawa²

2017

J Infect Dis Epidemiol

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Background: Serious gastrointestinal infection of Rotavirus (RV) is usually prevalent during winter months and often seen in infants and young children. Studies on genotypes of prevalent rotavirus strains are quite important for preventing infection, developing vaccines, and its evaluation. While at least 11 G genotypes have been isolated from humans, G1, G2, G3, G4, and emerging G9 are major genotypes of human RV. Although G6 human rotavirus is quite rare, it is the major type among rotaviruses from cattle. In this study we investigated the characteristics and origin of bovine RV strains from the children of the Nasu district, Tochigi, Japan.

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Emergence of Unusual G6P[6] Rotaviruses in Children, Burkina Faso, 2009–2010

Abstract: High incidence highlights the need for long-term surveillance of rotavirus strains.

Cited by 51 publications

References 40 publications

Evolution of a G6P[6] rotavirus strain isolated from a child with acute gastroenteritis in Ghana, 2012

Evolution of a G6P[6] rotavirus strain isolated from a child with acute gastroenteritis in Ghana, 2012

Rotavirus in diarrheal children in rural Burkina Faso: High prevalence of genotype G6P[6]

A Study on the Origin of Bovine Rotavirus Strains Detected from the Children of the Nasu District, Tochigi, Japan

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