Emergence of the OXA-23 carbapenemase-encoding gene in multidrug-resistant Acinetobacter baumannii clinical isolates from the Principal Hospital of Dakar, Senegal

Genetic support of carbapenemases: a One Health systematic review and meta‐analysis of current trends in Africa

“…In addition, bla OXA‐23‐like , bla OXA‐24‐like , bla OXA‐51‐like , bla OXA‐58‐like , and bla OXA235 were detected mostly in clinical Acinetobacter spp. In particular, bla OXA‐23‐like was detected in Egypt 56,96,110 and South Africa, 61,111 and specifically reported in clinical A. baumannii in Algeria, 59,112,113 Egypt, 62,63,99,114 Kenya, 58,115 Nigeria, 57 Senegal, 116 South Africa, 117,118 Tunisia, 119,120 and Uganda; 121 bla OXA‐23 was detected in clinical P. aeruginosa in Tunisia; 122 bla OXA‐24‐like ARGs were detected in clinical A. baumannii in Algeria, 59 Egypt, 99 South Africa, 111 and Uganda; 121 bla OXA‐40 was detected in Egypt; 62 bla OXA‐72 was detected in Algeria; 112 and bla OXA‐51‐like ARGs were detected mostly in clinical A. baumannii in Egypt, 56,96,110,123 Kenya, 58 and South Africa 61,111 . Other bla OXA‐51‐like variants were specifically identified in clinical A. baumannii in Algeria, 59,112 Egypt, 99,114 Senegal, 116 South Africa, 118 and Uganda; 121 bla OXA‐66 in clinical isolates in Kenya 58 and Tunisia; 120 and bla OXA‐94 in clinical isolates in Tunisia 60 .…”

The Molecular Epidemiology and Genetic Environment of Carbapenemases Detected in Africa

“…24 Kempf et al 41 discovered blaOXA-23 and novel oxacillinases from six human stools and three head lice respectively; the head lice CRAB isolates were of the rec A genotype 4, and four of the human stool CRAB isolates were of the rec A genotype 3. Diene et al 24 described the presence of an ISAba1 in a CRAB isolate upstream of an blaOXA-23 gene (Supplementary Table S1).…”

CTX-M-15-producing Morganella morganii from Hôpital Principal de Dakar, Senegal

“…The presence of ESBLs in M. morganii is also worrying because these bacteria are intrinsically resistant to colistin. As we have also recently described the emergence of the OXA-23 carbapenemase gene in multidrug-resistant A. baumannii isolates from this hospital [8] as well as the recent emergence of class D OXA-48 carbapenemase in Enterobacteriaceae in Senegal [13], it is urgent that local authorities are alerted to this problem to avoid the widespread dissemination of antibiotic-resistance genes and multidrug-resistant bacteria in all hospitals in Senegal.…”

“…Indeed, the few studies conducted in this region were on Enterobacteriaceae species including Shigella flexneri and Salmonella enterica, which are not classified as dominant nosocomial pathogens [6,7]. In this region, we have recently described the emergence of clinical multidrug-resistant Gram-negative bacteria, especially Acinetobacter baumannii, resistant to all b-lactams including the carbapenems [8], which has never been reported before in Senegal. Therefore, because of the emergence of multidrug-resistant bacilli such as A. baumannii and the paucity of studies focused on antibiotic resistance in clinical nosocomial pathogens, we conducted an epidemiological study to describe the prevalence and dissemination of antibiotic resistance genes in a large collection of clinical Enterobacteriaceae strains isolated from the Hôpital Principal de Dakar, Senegal.…”