CTX-M-15-producing Morganella morganii from Hôpital Principal de Dakar, Senegal

Diène, Seydina M.; Fénollar, Florence; Fall, B.; Sow, Kowry; Niang, Birahim; Ba, P.S.; Wade, B.; Raoult, Didier; Rolain, Jean‐Marc

doi:10.1002/nmi2.41

Cited by 5 publications

(3 citation statements)

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“…To our knowledge, this is one of the first studies to report the isolation of strains of E. coli producing CTX-M-15 -type ESBLs in Senegal. This type of ESBL was identified in several previous Senegalese studies: a study of 11 enterobacterial isolates, including one E. coli isolate [4] , and a study of 112 enterobacterial isolates, including 30 E. coli [5] isolates, as well as a number of Salmonella enterica strains [6] . Our study of 32 isolates of E. coli, 90.63% of which harboured the CTX-M-15 gene, showed that isolates of this type are becoming increasingly common in Senegal, as they are elsewhere in the world [1] .…”

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confidence: 72%

Molecular detection of CTX-M-15-type β-lactamases in Escherichia coli strains from Senegal

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Diagne

et al. 2016

New Microbes and New Infections

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confidence: 72%

Molecular detection of CTX-M-15-type β-lactamases in Escherichia coli strains from Senegal

Dia

Ngom

Diagne

et al. 2016

New Microbes and New Infections

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“…The bla SHV , bla TEM , bla CTX-A , and bla CTX-B genes have also been described in other enterobacteria such as K. pneumoniae and E. cloacae isolates. Other studies carried out in Senegal found the bla CTX-M-15 gene in Morganella morganii and the bla CTX-M group 1 and bla CTX-M group 9 genes in other enterobacterial species ( E. coli , K. pneumoniae , E. cloacae , and C. koseri ) isolated from urine, thus demonstrating the diversity of clinical enterobacteria isolates carrying these antibiotic resistance genes [ 43 , 46 ]. The genotypic results in Senegal confirm the presence as well as the circulation of CTX-M ESBL genes in E. coli between the west and the south of the country.…”

Section: Discussionmentioning

confidence: 91%

The Emergence of Carbapenem- and Colistin-Resistant Enterobacteria in Senegal

et al. 2023

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Antibiotic resistance is a public health problem. The emergence of carbapenemase-producing Enterobacterales (CPE) infections is a concern, particularly in Senegal. (1) Methods: Between January 2019 and July 2022, 240 isolates of enterobacteria resistant to third-generation cephalosporins and imipenem from biological samples from Fann Hospital (Dakar) and Hôpital Paix (Ziguinchor) were selected. The isolates were identified by MALDI-TOF mass spectrometry, and susceptibility tests were performed by the disk diffusion method. Antibiotic-resistance genes for class A beta-lactamases, carbapenemases, and plasmid resistance to colistin resistance (mcr-1–8) were screened by RT-PCR. (2) Results: The 240 enterobacteria were composed of: Escherichia coli (60.83%), Klebsiella pneumoniae (21.67%), Enterobacter cloacae (13.75%), Citrobacter freundii (2.08%), Serratia marcescens (0.83%), Klebsiella aerogenes (0.42%), and Proteus mirabilis (0.42%). Class A beta-lactamase genes were found in 229 isolates (70.41% blaTEM, 37.5% blaSHV, 83.75% blaCTX-A, and 0.42% blaCTX-B). The carbapenemase genes blaOXA-48 and blaNDM were found in 25 isolates, including 14 isolates with blaOXA-48, 13 isolates with blaNDM, and 2 isolates with both genes simultaneously. The mcr-8 gene was found in one isolate of E. cloacae. (3) Conclusions: The epidemiology of antibiotic-resistance genes in enterobacteria in Senegal shows the emergence of CPEs. This phenomenon is worrying, and rigorous surveillance is necessary to avoid further spread.

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“…It is carried by 96.87% of the isolates. CTX-M-15-type ESBLs have also been found in K. pneumoniae, 9 Salmonella enterica, 10 Morganella morgannii and K. pneumoniae, 11 in Senegal. It has also been isolated from K. pneumoniae strains in Nigeria.…”

Section: Discussionmentioning

confidence: 99%

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2019

JBMOA

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Enterobacteriaceae bacteria are an important bacterial family in human medicine. They are responsible for nosocomial and community infections. β-lactams antibiotics are the basic treatment for enteric infections. 1 These are increasingly resistant to beta-lactams by the production of extended spectrum β-lactamase (ESBL). The first narrow-spectrum penicillinases (TEM-1/2: Temoneira; SHV-1: sulfhydryl-variable) were detected in Escherichia coli and K. pneumoniae (K. pneumoniae) in the 1960s. 2 They were followed, in the 1980s, by SHV-2, an enzyme hydrolyzing broad-spectrum cephalosporins produced by K. pneumoniae. 3 The activity spectra of these enzymes are continually expanding to include other betalactams. Also, new enzymes, not derived from either TEMs or SHVs, have appeared and spread rapidly: CTX-M (cefotaximase-Munich) enzymes. 4 The overall aim of this study was to detect the production of ESBLs by isolates of K. pneumoniae in the Bacteriology Laboratory of Fan University Hospital (CHUF) in Dakar. The specific objective was to use molecular biology tests to characterize the genes encoding these enzymes.

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CTX-M-15-producing Morganella morganii from Hôpital Principal de Dakar, Senegal

Cited by 5 publications

References 16 publications

Molecular detection of CTX-M-15-type β-lactamases in Escherichia coli strains from Senegal

Molecular detection of CTX-M-15-type β-lactamases in Escherichia coli strains from Senegal

The Emergence of Carbapenem- and Colistin-Resistant Enterobacteria in Senegal

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