Emergence of Pathogenic Strains of Staphylococcus aureus in Goat Milk and Their Comparative Response to Antibiotics

Abstract

We evaluated the growth performance and the hepatoprotective and antioxidant effects of curcumin against carbon tetrachloride (CCl 4)-induced liver injury in common carp Cyprinus carpio. A 10-week feeding trial was carried out. A basal feed was supplemented with 0 (control), 30, 60, 120 and 240 mg/kg curcumin to formulate five experimental feeds. At the end of the feeding trial, the growth performance was determined. Subsequently, CCl 4 was used for the model experiment. The plasma and liver were collected for the test after 72 h. Results showed that there was a significant (P<0.05) increase in weight gain rate (WG) and a special growth rate (SGR) of fish fed feeds supplemented with 60 and 120 mg curcumin kg-1. When fish were induced by CCl 4 after 72 h, fish fed the diet supplemented with 120 mg (P5) curcumin kg-1 had significantly (P<0.05) lower plasma GOT, GPT activities and MDA content and higher plasma TP content and activities of liver SOD, GSH, GSH-Px and plasma T-AOC than those of P1 group. Curcumin (120 mg kg-1 curcumin per feed) inhibited the damage of liver tissue structure caused by carbon tetrachloride and made liver tissue structure return to normal. Meanwhile, dietary curcumin supplementation could also increase the live Nrf2 mRNA level and Nrf2 protein level in the liver nucleus, and those of the P5 group were highest. Overall, the results indicated that appropriate dietary curcumin supplementation could enhance the growth (especially 60 and 120 mg kg-1 curcumin per feed) of common carp and effectively protect the liver against CCl 4 induced injury (especially 120 mg kg-1 curcumin per feed) in fish.

Genomic and Therapeutic Analyses of Staphylococcus aureus Isolated from Cattle Reproductive Tract

“…Inflammatory expressions of the endometrium depict the fate of animals, as compromised fertility leads to premature culling [4]. S. aureus transfers at an animal-human-environment interface, thus making it a major threat to optimum reproductive efficiency in farm animals too [5][6][7]. Authentic diagnosis of various strains demands genome analyses because conventional microbiological methods are no longer enough [8].…”

MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework

“…The prevalence of LA-MRSA from different studies also noted higher from different countries as mentioned in Table 1 . Recent studies conducted in Pakistan detected 15.6% LA-MRSA from goat milk ( Muzammil et al, 2021 ), 24.5% from cow milk ( Lodhi et al, 2021 ), 30.4% from cats ( Shoaib et al, 2020 ), and 33.9% from dogs ( Shoaib et al, 2020 ). Another study conducted in Malaysia in 2018 detected 38.6% MRSA from cow milk ( Aklilu and Chia, 2020 ).…”

“…MRSA can also cause pyaemia which is a type of abscess which gain access to bloodstream and lead to sepsis ( Webster and Mitchell, 1989 ). MRSA in sheep and goats is among the predominant cause of clinical and subclinical mastitis which leads to high somatic cell count in milk and make milk unfavorable to drink ( Muzammil et al, 2021 ).…”