Emergence of mupirocin-resistant MRSA among Iranian clinical isolates

Sepehriseresht, Saeed; Boroumand, Mohammad Ali; Pourgholi, Leyla; Anvari, Maryam Sotoudeh; Habibi, Ehsan; Tabrizi, Mahboubeh Sattarzadeh; Speed, Mohammad

doi:10.1007/s00580-012-1472-z

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…MRSA can arise from MSSA upon specific site integration of SCC mec into the orfX locus in the chromosome of a susceptible isolate [44]. In the present study, prevalence of MSSA was 61.8% (92.6% among the various health professions and 88.7% in clinical samples), which is in line to the study in Gorgan [45], but was lower than Khosravi et al [46], Heidari et al [47], and Sepehriseresht et al [48] surveys. The gentamycin resistance rate in 37 MRSA strains was found to be 86.5%, which is higher than rates (60, 77, 78.2, and 40.5%) reported in other similar studies [2, 8, 40].…”

Section: Discussionsupporting

confidence: 90%

Molecular Characterization, Virulence Determinants, and Antimicrobial Resistance Profile of Methicillin-Resistant Staphylococcus aureus in the North of Iran; a High Prevalence of ST239-SCCmec III/t037 Clone

et al. 2021

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Objectives: Emergence and prevalence of methicillin-resistant Staphylococcus aureus (MRSA) have become a major universal health concern, limiting therapeutic options. Methods: A total number of 37 MRSA isolates, including 19 clinical isolates from hospitalized patients and 18 colonizing isolates from health care workers were identified from 3 hospitals, in Gorgan, North of Iran. Antimicrobial susceptibility test was performed using the disk diffusion method and E-test. The presence of virulence and antibiotic resistance determinants were evaluated by PCR. The genotypical characterization was further analyzed using multi-locus sequence, spa, staphylococcal cassette chromosome, mec (SCCmec), and agr typing. Results: The frequency of MRSA among S. aureus isolates was 38.14% (37/97). The most frequent S. aureus resistant isolates were found to be obstinate against penicillin (98%) and gentamicin (82.5%). Additionally, the lowest resistance rates were found against daptomycin (0%), vancomycin (2.7%), and quinupristin-dalfopristin (5.4%). All MRSA isolates were susceptible to daptomycin with minimum inhibitory concentration (MIC)50/MIC90 of 0.25/0.5 μg/mL. One isolate belonging to sequence type 239 (ST239)-SCCmecIII/t037 clone (MIC ≥16 μg/mL) was resistant to vancomycin. All but 1 isolate that shares ST22-SCCmec IV/t790 strain were positive for both tsst and pvl genes. The most predominant MRSA isolates (27%) were associated with ST239-SCCmec III/t037, and ST239-SCCmec III/t924 (16.2%) clones, subsequently. In our study, circulating MRSA strains were genetically diverse with a high prevalence of ST239-SCCmec III/t037 clone. Conclusion: These findings emphasize the need for future and continuous surveillance studies on MRSA to prevent the dissemination of existing multidrug resistance MRSA clones in an effective manner.

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Section: Discussionsupporting

confidence: 90%

Molecular Characterization, Virulence Determinants, and Antimicrobial Resistance Profile of Methicillin-Resistant Staphylococcus aureus in the North of Iran; a High Prevalence of ST239-SCCmec III/t037 Clone

et al. 2021

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“…A study conducted by Javan et al [ 32 ] reported 42.6 % frequency of MRSA in Tehran. However, the frequency of MRSA isolates in present study is more than the results of some previous reports published from Iran and some other countries [ 33-36 ].The estimated prevalence in our study was lower than that found in the studies of Khosravi et al [ 37 ], Heidari et al [ 38 ], Sepehriseresht et al [ 39 ], Saderi et al [ 40 ] and Gudarsi et al [ 25 ]. A systematic review displayed that prevalence of MRSA in Iran is high and varies between 20.4% and 90% in different parts of the country [ 41 ].…”

Section: Discussioncontrasting

confidence: 86%

Molecular Analysis of Immune Evasion Cluster (IEC) Genes and Intercellular Adhesion Gene Cluster (ica) Among Methicillin-Resistant and Methicillin-Sensitive Isolates of Staphylococcus aureus

Ahmadrajabi

layegh-khavidaki

Kalantar-Neyestanaki

et al. 2017

Journal of Preventive Medicine and Hygiene

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“…The widespread use of mupirocin has been linked to increasing rates of resistance at both institutional and national level. 7 Using the mupirocin E-test to determine susceptibility is not performed routinely in most clinical microbiology laboratories in South Africa.…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology of a suspected methicillin-resistant Staphylococcus aureus outbreak in a renal unit of a central academic hospital in KwaZulu-Natal, South Africa

Swe

Han

Naidoo

et al. 2015

Southern African Journal of Infectious Diseases

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Emergence of mupirocin-resistant MRSA among Iranian clinical isolates

Cited by 5 publications

References 19 publications

Molecular Characterization, Virulence Determinants, and Antimicrobial Resistance Profile of Methicillin-Resistant <b><i>Staphylococcus aureus</i></b> in the North of Iran; a High Prevalence of ST239-SCC<b><i>mec</i></b> III/t037 Clone

Molecular Characterization, Virulence Determinants, and Antimicrobial Resistance Profile of Methicillin-Resistant <b><i>Staphylococcus aureus</i></b> in the North of Iran; a High Prevalence of ST239-SCC<b><i>mec</i></b> III/t037 Clone

Molecular Analysis of Immune Evasion Cluster (IEC) Genes and Intercellular Adhesion Gene Cluster (ica) Among Methicillin-Resistant and Methicillin-Sensitive Isolates of Staphylococcus aureus

Molecular epidemiology of a suspected methicillin-resistant Staphylococcus aureus outbreak in a renal unit of a central academic hospital in KwaZulu-Natal, South Africa

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