Emergence of colistin resistance in Klebsiella pneumoniae ST15 disseminating blaKPC-2 in a novel genetic platform

Álvarez, Verónica Elizabeth; Massó, Mariana; González, Gabriela D'amico; Gambino, Anahí S.; Knecht, Camila A.; McCormick, Barbara Prack; Leguina, Ana Carolina del Valle; Piekar, María; Poklépovich, Tomás; Campos, Josefina; Arduino, S.; Centrón, Daniela; Quiroga, María Paula

doi:10.1016/j.jgar.2021.12.001

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“…Furthermore, pK528_mcr-10 showed 58% coverage and 99.9% identity with pKp_Goe_795-1, which was isolated from K. pneumoniae belonging to ST15. Recently, this pathogen was identified as the cause of several nosocomial infections in Asia, Europe, Africa, and Brazil ( 23 ).…”

Section: Resultsmentioning

confidence: 99%

Emergence and Transmission of Plasmid-Mediated Mobile Colistin Resistance Gene mcr-10 in Humans and Companion Animals

et al. 2022

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Colistin was considered as the last-resort drug against severe clinical infections caused by multidrug-resistant Gram-negative pathogens. Mobile colistin resistance ( mcr ) genes and its variants carried by plasmids have been reported in diverse niches in recent years, and yet few studies reported carriage of mcr-10 in ECC strains of companion animal origin.

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Section: Resultsmentioning

confidence: 99%