Emergence of canine parvovirus type 2c (CPV-2c) of Asian origin in domestic dogs in Myanmar

Mon, Pont Pont; Thurain, Khin; Charoenkul, Kamonpan; Nasamran, Chanakarn; Wynn, Myint; Tun, Than Naing; Amonsin, Alongkorn

doi:10.1016/j.cimid.2022.101901

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…In subsequent years, this Asian lineage has been detected also in non-Asian countries, such as Italy [ 14 ] and other European countries [ 50 , 54 ], Africa [ 24 , [55] , [56] , [57] ], and North America [ 58 ]. As observed in this study, since 2020, a rapid trend of transition from CPV-2a/CPV-2b to CPV-2c predominance was documented also in different Asian countries [ [59] , [60] , [61] , [62] , [63] ].…”

Section: Discussionsupporting

confidence: 55%

Molecular epidemiology of canine parvovirus type 2 in Sicily, southern Italy: A geographical island, an epidemiological continuum

Mira,

Schirò,

Franzo

et al. 2024

Heliyon

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Section: Discussionsupporting

confidence: 55%

Molecular epidemiology of canine parvovirus type 2 in Sicily, southern Italy: A geographical island, an epidemiological continuum

Mira,

Schirò,

Franzo

et al. 2024

Heliyon

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“…Over time, different studies have reported a plethora of other potential genetic variants, which have shown inconsistent epidemiological success. Most recently, an increase in the detection frequency of the so-called “Asian CPV-2c” lineage was observed [ 27 , 28 , 29 , 30 , 32 , 48 ]. However, no systematic study has been performed to evaluate its molecular epidemiology and evolution on a broader scale.…”

Section: Discussionmentioning

confidence: 99%

“…This finding confirms the huge spreading potential that has characterized the history of CPV-2 and, thus, the need for more effective and systematic monitoring activities to promptly detect and effectively react to emerging viruses. In fact, the increase in population size also mirrored the viral introduction to new areas of the world, and strains belonging to this lineage have been reported particularly in Asia [ 30 , 51 , 52 ], Europe [ 25 , 27 , 29 , 53 ], and Africa [ 31 , 54 , 55 ], although there is also a report from North America [ 12 ]. Furthermore, in recent years, an increasing number of studies from Asia have highlighted not only the progressive spread of the Asian CPV-2c lineage but also the progressive replacement of the circulating CPV-2 strains by this lineage, as if it had potentially greater viral fitness [ 56 , 57 , 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

“…This is the case for the so-called “Asian CPV-2c” lineage, a monophyletic group of viruses characterized by a specific set of mutations in both structural and non-structural proteins [ 25 ]. This clade was recorded for the first time in Asian countries, where it became more and more prevalent as years passed by, and it was recently introduced to several other countries worldwide, where it is now spreading and locally evolving [ 12 , 27 , 28 , 29 , 30 , 31 , 32 ]. However, the understanding of the real success, population dynamics, and spreading patterns of this clade are hindered by sparse and biased diagnostic and sequencing activity.…”

Section: Introductionmentioning

confidence: 99%

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Not Asian Anymore: Reconstruction of the History, Evolution, and Dispersal of the “Asian” Lineage of CPV-2c

Franzo,

Mira,

Schirò

et al. 2023

Viruses

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Variability has been one of the hallmarks of canine parvovirus type 2 (CPV-2) since its discovery, and several lineages and antigenic variants have emerged. Among these, a group of viruses commonly called Asian CPV-2c has recently been reported with increasing frequency in different regions. Currently, its global epidemiology and evolution are essentially unknown. The present work deals with this information gap by evaluating, via sequence, phylodynamic, and phylogeographic analyses, all the complete coding sequences of strains classified as Asian CPV-2c based on a combination of amino acid markers and phylogenetic analysis. After its estimated origin around 2008, this lineage circulated undetected in Asia until approximately 2012, when an expansion in viral population size and geographical distribution occurred, involving Africa, Europe, and North America. Asia was predicted to be the main nucleus of viral dispersal, leading to multiple introduction events in other continents/countries, where infection establishment, persistence, and rapid evolution occurred. Although the dog is the main host, other non-canine species were also involved, demonstrating the host plasticity of this lineage. Finally, although most of the strains showed an amino acid motif considered characteristic of this lineage, several exceptions were observed, potentially due to convergent evolution or reversion phenomena.

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Canine parvovirus in North-East India: a phylogenetic and evolutionary analysis

Jayappa,

Rajkhowa,

Gaikwad

2024

Veterinary Quarterly

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Canine parvovirus type 2 (CPV-2) infection in dogs is considered as one of the most common cause of morbidity and mortality in young dogs and continues to occur with high incidence worldwide. Despite a single-stranded DNA virus, CPV-2 possesses a high mutation rate which has led to the development of new variants from time to time. These variants are classically classified based on the amino acid markers present in the VP2 gene. In this study, we examined 20 different cases of CPV-2 infection from seven different states of the North East region (NER) of India. The near-complete genome sequences of all these isolates were subjected to phylodynamic and phylogeographic analysis to evaluate the genetic diversity and geographical spread of CPV-2 variants. Analysis of the deduced amino acid sequences revealed residues characteristic of the ‘Asian CPV-2c lineage’ in all the 20 sequences confirming it as the dominant strain circulating in NER, India. The phylogenetic analysis based on the whole genome showed that all 20 sequences formed a monophyletic clade together with other Asian CPV-2c sequences. Furthermore, phylogeographic analysis based on the VP2 gene showed the likely introduction of Asian CPV-2c strain to India from China. This study marks the first comprehensive report elucidating the molecular epidemiology of CPV-2 in India.

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Emergence of canine parvovirus type 2c (CPV-2c) of Asian origin in domestic dogs in Myanmar

Cited by 4 publications

References 27 publications

Molecular epidemiology of canine parvovirus type 2 in Sicily, southern Italy: A geographical island, an epidemiological continuum

Molecular epidemiology of canine parvovirus type 2 in Sicily, southern Italy: A geographical island, an epidemiological continuum

Not Asian Anymore: Reconstruction of the History, Evolution, and Dispersal of the “Asian” Lineage of CPV-2c

Canine parvovirus in North-East India: a phylogenetic and evolutionary analysis

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