Emergence of an independent lineage of dengue virus type 1 (DENV-1) and its co-circulation with predominant DENV-3 during the 2006 dengue fever outbreak in Delhi

Kukreti, Himani; Chaudhary, Anjali; Rautela, Rajendra Singh; Anand, Ranjana; Mittal, Veena; Chhabra, Mala; Bhattacharya, Dipesh; Lal, Shiv; Rai, Arvind

doi:10.1016/j.ijid.2008.02.009

Cited by 51 publications

(44 citation statements)

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“…Subsequently, Central Western Indian states (Gujarat, Madhya Pradesh and Rajasthan) were affected [6,21]. By the end of 2006, sporadic cases of CHIKV infection along with massive dengue outbreak in Delhi were reported [22,34]. Few cases were also reported from Haryana and Uttar Pradesh [18,35].…”

Section: Discussionmentioning

confidence: 99%

Northward movement of East Central South African genotype of Chikungunya virus causing an epidemic between 2006-2010 in India

Singh

Mittal

Rizvi

et al. 2012

J Infect Dev Ctries

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Introduction: Re-emergence of chikungunya virus in South India after a gap of 32 years in 2006 affected over a million people in the Indian subcontinent. We kept a close vigil over the emerging trend of this virus between 2006-2010 with a view to establish the identity of the circulating genotype(s) and to determine the route of virus transmission in different parts of India. Methodology: Nucleotide sequencing of the E1 gene region from 36 strains of chikungunya virus from three states in northern India was performed for this present study. Forty-four previously reported E1 sequences, retrieved from the global genome data base were used for making a phylogenetic tree.

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Section: Discussionmentioning

confidence: 99%

Northward movement of East Central South African genotype of Chikungunya virus causing an epidemic between 2006-2010 in India

Singh

Mittal

Rizvi

et al. 2012

J Infect Dev Ctries

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“…Existe suficiente información que demuestra la coincidencia entre el cambio del serotipo predominante y el cambio en la incidencia del dengue, en áreas hiperendémicas de Latinoamérica y Asia (1,(5)(6)(7). También, se ha reportado incremento en la incidencia que coincide con la introducción de un genotipo distinto y con la diversificación genética del genotipo presente, la cual puede llevar a extinción, reemplazo y circulación simultánea de linajes (8)(9)(10)(11)(12).…”

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Virus dengue serotipo 1 (VDEN-1) de Colombia: su contribución a la ocurrencia del dengue en el departamento de Santander

et al. 2012

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-Jiménez: diseño del estudio, análisis de datos y escritura del manuscrito. Ayda Susana Ortiz-Báez: amplificación de secuencias genómicas y análisis filogenético. Sergio Yebrail Gómez-Rangel: aislamientos virales, análisis de datos y revisión del manuscrito. Daniel R. Miranda-Esquivel: análisis filogenético y escritura del manuscrito. ARTÍCULO ORIGINAL Biomédica 2013;33(Supl. Introducción. Los cuatro serotipos del virus del dengue circularon en el departamento de Santander entre 1998 y 2008. No existe información sobre el papel del serotipo 1 (DENV-1) en la epidemiología de la enfermedad. Objetivo. Analizar la relación entre el cambio de predominancia del (DENV-1) con su diversificación genética, predominancia de los otros serotipos y presentación del dengue grave. Materiales y métodos. La diversificación genética se estudió por análisis filogenético usando la secuencia del gen E de 12 cepas del virus. Para el análisis se utilizaron datos sobre predominancia de los serotipos obtenidos en estudios previos y datos oficiales de incidencia del dengue. Resultados. Los virus seleccionados se agruparon en el genotipo V junto a (DENV-1) de países de Latinoamérica y se evidenció segregación en cuatro linajes. Los cambios en la predominancia del virus coincidieron con el reemplazo de linaje y esto, a su vez, con incremento en la prevalencia de DENV-2 y DENV-3, e incremento del dengue grave. Conclusión. La diversificación genética podría contribuir a cambios de predominancia de (DENV-1), y la relación del virus con el DENV-2 y DENV-3 en situaciones que favorecen la presentación de casos graves. Se necesitan más estudios para precisar el papel de los serotipos en la epidemiología del dengue. Objective: To analyze the relationship between changes in DENV-1 predominance with respect to genetic diversity, prevalence of others serotypes and occurrence of severe dengue. Methods: Virus genetic diversity was studied by phylogenetic analysis comparing E gene sequences from 12 viral strains. Data about serotypes predominance obtained in previous studies and official data about dengue incidence were used for analysis. Results: Selected viruses grouped into genotype V together DENV-1 from Latin America countries, and segregation in four lineages was evidenced. Changes in virus predominance coincided with replacement of lineage, increase in prevalence of DENV-2 and DENV-3 and increase of severe dengue. Conclusion: Genetic divergence could have contributed to changes in DENV-1 predominance. The relationship of the virus with DENV-2 and DENV-3 could create scenarios that promote occurrence of severe cases. More studies are required to ascertain the precise role of serotypes in the epidemiology of dengue.

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“…However, Singh and Seth 5 suggested that fragments of the capsid-premembrane junction region (CprM) might be a faster and cheaper alternative for sequencing short regions. Since then, CprM has been used by a number of authors [6][7][8] . Genes that code for non-structural proteins have also been sequenced and used in phylogeny studies 9 .…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity of dengue virus serotypes 1 and 2 in the State of Paraná, Brazil, based on a fragment of the capsid/premembrane junction region

Bona

Twerdochlib

Navarro-Silva

2012

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION: The precise identification of the genetic variants of the dengue virus is important to understand its dispersion and virulence patterns and to identify the strains responsible for epidemic outbreaks. This study investigated the genetic variants of the capsid-premembrane junction region fragment in the dengue virus serotypes 1 and 2 (DENV1-2). METHODS: Samples from 11 municipalities in the State of Paraná, Brazil, were provided by the Central Laboratory of Paraná. They were isolated from the cell culture line C6/36 (Aedes albopictus) and were positive for indirect immunofluorescence. Ribonucleic acid (RNA) extracted from these samples was submitted to the reverse transcription polymerase chain reaction (RT-PCR) and nested PCR. RESULTS: RT-PCR revealed that 4 of the samples were co-infected with both serotypes. The isolated DENV-1 sequences were 95-100% similar to the sequences of other serotype 1 strains deposited in GenBank. Similarly, the isolated DENV-2 sequences were 98-100% similar to other serotype 2 sequences in GenBank. According to our neighbor-joining tree, all strains obtained in this study belonged to genotype V of DENV-1. The DENV-2 strains, by contrast, belonged to the American/Asian genotypes. CONCLUSIONS: The monitoring of circulating strains is an important tool to detect the migration of virus subtypes involved in dengue epidemics.

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Emergence of an independent lineage of dengue virus type 1 (DENV-1) and its co-circulation with predominant DENV-3 during the 2006 dengue fever outbreak in Delhi

Abstract: It is feared that the introduction of an independent lineage of the outbreak-associated strain of DENV-1 and its co-circulation with the deeply-rooted strain of DENV-3 in Delhi may result in yet another, possibly more severe outbreak in the near future.

Cited by 51 publications

References 29 publications

Northward movement of East Central South African genotype of Chikungunya virus causing an epidemic between 2006-2010 in India

Northward movement of East Central South African genotype of Chikungunya virus causing an epidemic between 2006-2010 in India

Virus dengue serotipo 1 (VDEN-1) de Colombia: su contribución a la ocurrencia del dengue en el departamento de Santander

Genetic diversity of dengue virus serotypes 1 and 2 in the State of Paraná, Brazil, based on a fragment of the capsid/premembrane junction region

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