Emergence and Characterization of Human Rotavirus G9 Strains in Tunisia

Chouikha, Anissa; Fodha, I.; Bouslama, Lamjed; Fredj, M. Ben; Jaoua, Samir; Boujaafar, N.; Trabelsi, Abdelhalim; Steele, A. Duncan

doi:10.1086/605029

Cited by 9 publications

(10 citation statements)

References 13 publications

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“…This rate is similar to those reported in the Tunisian studies conducted between 1995 and 2008 by the national RV surveillance group (17.3-26.2 %) (Ben Hadj Fredj et al, 2012;Chouikha et al, 2009Chouikha et al, , 2011aTrabelsi et al, 2000Trabelsi et al, , 2010. Moreover, it is comparable to the detection rates reported for African countries where RV vaccine is not yet included in the free national childhood programme: 25.2 % in Egypt (Matson et al, 2010), 18 % in Tanzania (Moyo et al, 2007) and 18 % in Nigeria (Aminu et al, 2010).…”

Section: Rva Detection Ratesupporting

confidence: 89%

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Distribution of rotavirus VP7 and VP4 genotypes circulating in Tunisia from 2009 to 2014: Emergence of the genotype G12

Moussa

Fredj

Fodha

et al. 2016

Journal of Medical Microbiology

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Group A rotavirus (RVA) represents the most important aetiological agent of diarrhoea in children worldwide. From January 2009 to December 2014, a multi-centre study realized through 11 Tunisian cities was undertaken among children aged <5 years consulting or hospitalized for acute gastroenteritis. A total of 1127 faecal samples were collected. All samples were screened by ELISA for the presence of RVA antigen. RVA-positive samples were further analyzed by PAGE and used for G/P-genotyping by semi-nested multiplex RT-PCR. Globally, 270 specimens (24 %) were RVA-positive, with peaks observed annually between November and March. Nine different electropherotypes could be visualized by PAGE, six with a long profile (173 cases) and two with a short one (seven cases). Mixed profiles were detected in two cases. Among the 267 VP7 genotyped strains, the predominant G-genotype was G1 (39.6 %) followed by G3 (22.2 %), G4 (13 %), G9 (11.5 %), G2 (5.2 %) and G12 (5.2 %). Among the 260 VP4 genotyped strains, P[8] genotype was the predominant (74. 9 %). Uncommon G/Pgenotype combinations, mixed infections and untypeable strains were also detected. This is the first report, in Tunisia, of multiple detection of an emerging human RVA strain, G12 genotype. This study highlighted the need for maintaining active surveillance of emerging strains in Northern Africa.

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Section: Rva Detection Ratesupporting

confidence: 89%

“…Its prevalence increased markedly around the world in the late 1990s (Santos & Hoshino, 2005). In Tunisia, the G9 genotype was isolated for the first time in 2004 and its rate detection remained quite low (2.5-3.3 %) until 2007 (Chouikha et al, 2009). …”

Section: G/p-typingmentioning

confidence: 99%

Distribution of rotavirus VP7 and VP4 genotypes circulating in Tunisia from 2009 to 2014: Emergence of the genotype G12

Moussa

Fredj

Fodha

et al. 2016

Journal of Medical Microbiology

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“…Data on the proportion of RVGE was available from the following countries: Egypt [17-21], Iran [18,22-27], Iraq [18,28], Jordan [18,29], Kuwait [30], Libya [18,31,32], Morocco [18,33], Oman [18,34,35], Saudi Arabia [36-40], Syria [18], Tunisia [18,41-46], Turkey [14,15,47-50], and Yemen [18]. No studies were found from Algeria, Bahrain, Israel, Qatar, and the United Arab Emirates.…”

Section: Resultsmentioning

confidence: 99%

“…Among the countries with the lowest proportion of RVGE (16% to 23%) were Saudi Arabia [36-40], Tunisia [18,41-46], and Egypt [17-19,51]. Those with the highest proportion of RVGE included Syria (61%) [18], Oman (50%) [18,34,35], and Kuwait (44%) [30].…”

Section: Resultsmentioning

confidence: 99%

Burden of rotavirus gastroenteritis in the Middle Eastern and North African pediatric population

Khoury¹,

Ogilvie²,

Khoury

et al. 2011

BMC Infect Dis

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BackgroundRotavirus gastroenteritis (RVGE) is the most common cause of severe childhood diarrhea worldwide. Objectives were to estimate the burden of RVGE among children less than five years old in the Middle East (Bahrain, Iran, Iraq, Israel, Jordan, Kuwait, Oman, Qatar, Saudi Arabia, Syria, UAE, Yemen), North Africa (Algeria, Egypt, Libya, Morocco, Tunisia) and Turkey.MethodsA comprehensive literature search was conducted in major databases on the epidemiology and burden of rotavirus among children less than five years old between 1999 and 2009. Data from each country was extracted and compared.ResultsThe search identified 43 studies. RVGE was identified in 16-61% of all cases of acute gastroenteritis, with a peak in the winter. RVGE-related hospitalization rates ranged from 14% to 45%, compared to 14%-28% for non-RVGE. Annually, RVGE caused up to 112 fatalities per 100,000 in certain countries in the region. Hospitalization costs ranged from $1.8 to $4.6 million annually, depending on the country. The most recent literature available showed that G1P[8] was the most prevalent genotype combination in 8 countries (range 23%-56%). G2P[4] was most prevalent in 4 countries (26%-48%). G9P[8] and G4P[8] were also frequently detected.ConclusionsRVGE is a common disease associated with significant morbidity, mortality, and economic burden. Given the variety and diverse rotavirus types in the region, use of a vaccine with broad and consistent serotype coverage would be important to help decrease the burden of RVGE in the Middle East and North Africa.

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“…It showed that rotavirus was responsible for 23.3% of hospitalized cases of acute gastroenteritis among children < 5 years of age in the central-east of Tunisia, with a peak occurring between December and February. From 1995 to 2005, 4 studies conducted in the same region of Tunisia have reported rotavirus rates ranging from 17.3% to 20.8% (8)(9)(10)(11), confirming the endemicity of rotavirus-positive acute gastroenteritis cases in the region, and its rising trend.…”

Section: Discussionmentioning

confidence: 86%

Epidemiology and medical cost of hospitalization due to rotavirus gastroenteritis among children under 5 years of age in the central-east of Tunisia

Soltani

Salah

Bouanène

et al. 2015

Easter Mediterr Health J

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Data on the economic burden of rotavirus infection in Tunisia are needed to inform the decision to include rotavirus in routine childhood immunizations. This study aimed to describe the epidemiological profile of rotavirus disease in central-east Tunisia and to estimate its hospital cost. In the first stage -the prospective collection of epidemiological data -we enrolled all patients < 5 years old who were hospitalized for acute diarrhoea at 5 university paediatric departments in central-east Tunisia during the period 2009-2011. Rotavirus was responsible for 65 (23.3%) of the 279 cases enrolled. In the second stage, cost data were collected retrospectively using an activity-based costing method from the medical records of the children who were positively diagnosed with rotavirus. The average cost of care per child was TD 433 (SD 134). This is a significant economic burden in Tunisia, where a safe and effective vaccine is available but not yet introduced to the immunization schedule. ‫ـن‬ ‫الذيـ‬ ‫ـال‬ ‫األطفـ‬ ‫ـدى‬ ‫لـ‬

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Emergence and Characterization of Human Rotavirus G9 Strains in Tunisia

Cited by 9 publications

References 13 publications

Distribution of rotavirus VP7 and VP4 genotypes circulating in Tunisia from 2009 to 2014: Emergence of the genotype G12

Distribution of rotavirus VP7 and VP4 genotypes circulating in Tunisia from 2009 to 2014: Emergence of the genotype G12

Burden of rotavirus gastroenteritis in the Middle Eastern and North African pediatric population

Epidemiology and medical cost of hospitalization due to rotavirus gastroenteritis among children under 5 years of age in the central-east of Tunisia

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