Emeniveol; A new pollen growth inhibitor from the fungus, Emericella nivea

Kimura, Yasuo; Nishibe, Masahiko; Nakajima, Hiromitsu; Hamasaki, Takashi; Shigemitsu, N.; Sugawara, Fumio; Stout, Thomas J.; Clardy, Jon

doi:10.1016/s0040-4039(00)60913-9

Cited by 35 publications

(22 citation statements)

References 5 publications

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“…2011), showing several chemical similarities between A. cejpii with its phylogenetic sister group section Fumigati . Furthermore, indoloterpenes, such as JBIR-03, emeniveol, emindol SB, emindole SB mannoside, asporyzin A-C, 27-O-methylasporyzin C (Ogata et al., 2007, Qiao et al., 2010a, Qiao et al., 2010b, Harms et al., 2014) can be also found in common with species in subgenus Circumdati and Nidulantes (Nozawa et al., 1988, Kimura et al., 1992). Finally, tryptoquivalones in common with species of section Clavati and Fumigati (Varga et al., 2007, Frisvad and Larsen, 2016), while asporyergosterols and similar bioactive sterols (Qiao et al., 2010a, Harms et al., 2015b) in common with several Aspergilli, and heveadrides in common with Aspergillus section Aspergillus (Slack et al., 2009, Harms et al., 2015a) have also been found.…”

Section: Resultsmentioning

confidence: 99%

Aspergillus is monophyletic: Evidence from multiple gene phylogenies and extrolites profiles

Kocsubé¹,

Perrone²,

Magistà³

et al. 2016

Studies in Mycology

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Aspergillus is one of the economically most important fungal genera. Recently, the ICN adopted the single name nomenclature which has forced mycologists to choose one name for fungi (e.g. Aspergillus, Fusarium, Penicillium, etc.). Previously two proposals for the single name nomenclature in Aspergillus were presented: one attributes the name “Aspergillus” to clades comprising seven different teleomorphic names, by supporting the monophyly of this genus; the other proposes that Aspergillus is a non-monophyletic genus, by preserving the Aspergillus name only to species belonging to subgenus Circumdati and maintaining the sexual names in the other clades. The aim of our study was to test the monophyly of Aspergilli by two independent phylogenetic analyses using a multilocus phylogenetic approach. One test was run on the publicly available coding regions of six genes (RPB1, RPB2, Tsr1, Cct8, BenA, CaM), using 96 species of Penicillium, Aspergillus and related taxa. Bayesian (MrBayes) and Ultrafast Maximum Likelihood (IQ-Tree) and Rapid Maximum Likelihood (RaxML) analyses gave the same conclusion highly supporting the monophyly of Aspergillus. The other analyses were also performed by using publicly available data of the coding sequences of nine loci (18S rRNA, 5,8S rRNA, 28S rRNA (D1-D2), RPB1, RPB2, CaM, BenA, Tsr1, Cct8) of 204 different species. Both Bayesian (MrBayes) and Maximum Likelihood (RAxML) trees obtained by this second round of independent analyses strongly supported the monophyly of the genus Aspergillus. The stability test also confirmed the robustness of the results obtained. In conclusion, statistical analyses have rejected the hypothesis that the Aspergilli are non-monophyletic, and provided robust arguments that the genus is monophyletic and clearly separated from the monophyletic genus Penicillium. There is no phylogenetic evidence to split Aspergillus into several genera and the name Aspergillus can be used for all the species belonging to Aspergillus i.e. the clade comprising the subgenera Aspergillus, Circumdati, Fumigati, Nidulantes, section Cremei and certain species which were formerly part of the genera Phialosimplex and Polypaecilum. Section Cremei and the clade containing Polypaecilum and Phialosimplex are proposed as new subgenera of Aspergillus. The phylogenetic analysis also clearly shows that Aspergillus clavatoflavus and A. zonatus do not belong to the genus Aspergillus. Aspergillus clavatoflavus is therefore transferred to a new genus Aspergillago as Aspergillago clavatoflavus and A. zonatus was transferred to Penicilliopsis as P. zonata. The subgenera of Aspergillus share similar extrolite profiles indicating that the genus is one large genus from a chemotaxonomical point of view. Morphological and ecophysiological characteristics of the species also strongly indicate that Aspergillus is a polythetic class in phenotypic characters.

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Section: Resultsmentioning

confidence: 99%

Aspergillus is monophyletic: Evidence from multiple gene phylogenies and extrolites profiles

Kocsubé¹,

Perrone²,

Magistà³

et al. 2016

Studies in Mycology

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“…The culture was a mixed culture with a strain of Aspergillus parasiticus . Later reports on aflatoxin production by A. oryzae were erroneous (Varga et al 2009 ) Aflatoxin G1 in A. flavus Saldan et al ( 2018 ) Aflatoxin G 1 has only been found very rarely in A. flavus but has been found more often in other species in section Flavi (Frisvad et al 2019 ) Asperaculin A Son et al ( 2018 ) Identity of strain (KCCM 12698) and compound dubious, compound only tentatively assigned Asperentin = cladosporin, asperentin 8-O-methylether, asperentin 6-O-methyl ether, 5′-hydroasperentin Grove (1972a, 1973a ) Producer strain is A. pseudoglaucus (Chen et al 2017 ) Asperflavin, anhydroasperflasvin, 5,7-dihydroxy-4-methylphthalide Grove ( 1972b ) Producer strain is A. pseudoglaucus (Chen et al 2017 ) Asporyzin A, B and C Qiao et al ( 2010a ); Nozawa et al ( 1988 ); Kimura et al ( 1992 ) Producer strain is A. niveus , A. cejpii or A. striatus Austalide F & H Son et al ( 2018 ) Identity of strain and compound dubious, compounds tentatively assigned Aspyrone Saldan et al ( 2018 ) Identity of strain and compound dubious Betaine Saldan et al ( 2018 ) Identity of strain and compound dubious Chrysogine Saldan et al ( 2018 ) Chrysogine has not been found in A. flavus , but in other members of Aspergillus section Flavi (Frisvad et al 2019 ) Cyclopenol Zhuravleva et al ( 2016 ) Producer strain was probably Aspergillus amoenus Deacetoxyscirpenol (DON) …”

Section: Secondary Metabolite Potentialmentioning

confidence: 99%

Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei

Frisvad

Møller

Larsen

et al. 2018

Appl Microbiol Biotechnol

238

269

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This review presents an update on the current knowledge of the secondary metabolite potential of the major fungal species used in industrial biotechnology, i.e., Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei. These species have a long history of safe use for enzyme production. Like most microorganisms that exist in a challenging environment in nature, these fungi can produce a large variety and number of secondary metabolites. Many of these compounds present several properties that make them attractive for different industrial and medical applications. A description of all known secondary metabolites produced by these species is presented here. Mycotoxins are a very limited group of secondary metabolites that can be produced by fungi and that pose health hazards in humans and other vertebrates when ingested in small amounts. Some mycotoxins are species-specific. Here, we present scientific basis for (1) the definition of mycotoxins including an update on their toxicity and (2) the clarity on misclassification of species and their mycotoxin potential reported in literature, e.g., A. oryzae has been wrongly reported as an aflatoxin producer, due to misclassification of Aspergillus flavus strains. It is therefore of paramount importance to accurately describe the mycotoxins that can potentially be produced by a fungal species that is to be used as a production organism and to ensure that production strains are not capable of producing mycotoxins during enzyme production. This review is intended as a reference paper for authorities, companies, and researchers dealing with secondary metabolite assessment, risk evaluation for food or feed enzyme production, or considerations on the use of these species as production hosts.

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“…[4][5][6] Identification of these compounds was accomplished by analysis of 1D and 2D NMR data and comparison with literature values. [4][5][6] In order to determine the chemical defensive function of this endophytic fungus A. oryzae for the marine red alga H. japonica, compounds 1-6 were examined for insecticidal and antimicrobial activities. Compound 4 was more active in the assay for insecticidal activity against brine shrimp (Artemia salina), 11 which was probably due to the presence of indole and tetrahydrofuran units by comparison with the other compounds ( Table 2).…”

Section: Introductionmentioning

confidence: 99%