Embryotoxic effects of chromium trioxide in hamsters

Gale, Thomas F.

doi:10.1016/0013-9351(78)90147-0

Cited by 57 publications

(21 citation statements)

References 25 publications

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“…Hydrocephalus could be induced by in utero exposure to a virus (Takano et al, 1999), toxins (Hood et al, 1976), chromium trioxide (Gale, 1978a) and lead (Gale, 1978b). It could also be induced by intracerebral inoculation with various viruses (Johnson and Johnson, 1968;Kilham and Margolis, 1969;Breschkin et al, 1976;Davis, 1981;Lagace-Simard et al, 1982), bacteria (Kohn et al, 1977 and1984) and chemicals (Mantovani et al, 1998;Azzi et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Hereditary hydrocephalus internus in a laboratory strain of golden hamsters (Mesocricetus auratus)

Gebhardt-Henrich

Edwards

Famula

et al. 2008

Animal

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Golden hamsters of one common laboratory strain had a high incidence of hydrocephalus internus. When a severity score of hydrocephalus was used, a major autosomal recessive locus could be identified. However, when a binary score (hydrocephalus, no hydrocephalus) was used, no such major locus could be detected and results of test matings were not consistent with Mendelian inheritance. Golden hamsters with severe forms of hydrocephalus had a dorsally compressed and ventrally intact hippocampus. Implications for the behavior and well-being of affected hamsters are unknown but researchers using this strain should be aware of the likely presence of hydrocephalus.

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Section: Discussionmentioning

confidence: 99%

Hereditary hydrocephalus internus in a laboratory strain of golden hamsters (Mesocricetus auratus)

Gebhardt-Henrich

Edwards

Famula

et al. 2008

Animal

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“…Exposure to chromium (III) or chromium (VI) compounds may result in developmental effects via the parenteral route, however. In studies by Gale (1978) and Gale and Bunch (1979), increased fetal death and an increase in external abnormalities were observed in hamsters treated by intravenous injection with Cr0 3 (chromium (VI)) on a single day of gestation. Matsumoto, et al, 1976 observed fetal weight depression and an increase in external abnormalities in the fetuses of mice treated intraperitoneally with CrCl 3 at 14.64-24.4 mg/kg chromium (III) on the eighth day of gestation.…”

Section: Mutagenicitymentioning

confidence: 99%