Embryos generated using testicular spermatozoa have higher developmental potential than those obtained using epididymal spermatozoa in men with obstructive azoospermia

Dozortsev, Dmitri; Neme, R.M.; Diamond, Michael P.; Abdelmassih, S.; Abdelmassih, V.; Oliveira, Flávio G.; Abdelmassih, Roger

doi:10.1016/j.fertnstert.2006.01.036

Cited by 33 publications

(27 citation statements)

References 26 publications

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“…In such cases, moving proximally from the obstruction gets away from the area containing a high proportion of degraded spermatozoa. Taking of samples in this area may be why some investigators have found human testicular sperm more useful in ICSI procedures than sperm from obstructed epididymides (Dozortesev et al, 2006). Moving as far distally along the epididymis as possible while still remaining proximal to the region of degraded sperm allows the highest possibility of success in obtaining sperm useful for ART.…”

Section: Epididymal Functionsmentioning

confidence: 99%

De Graaf's Thread: The Human Epididymis

Turner

2008

Journal of Andrology

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The epididymis consists of a single, highly coiled and convoluted tubule that Antoine De Graaf, the famous 17th-century anatomist, likened to a thread thickening to a string. The uncoiled tubule is several meters long and sperm in transit through it become functionally mature under the under the influence of the tubule lumen's microenvironment. The regulation of that microenvironment and the manner by which it influences sperm maturation have been the topic of investigation for many years, though the study of the human epididymis directly is fraught with problems related to sample availability and condition. Nevertheless, investigations using a variety of mammalian tissue sources, human included, have resulted in significant advances in our understanding of both the biology and pathology of the organ. The epididymal functions of transporting, concentrating, maturing, and storing sperm are important to male fertility and their absence or significant impairment can be a factor in male infertility.

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Section: Epididymal Functionsmentioning

confidence: 99%

De Graaf's Thread: The Human Epididymis

Turner

2008

Journal of Andrology

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“…However, patients in the testicular sperm group exhibited significantly higher IR (20.8 versus 32.8%, p = 0.008), with a trend toward higher ongoing PR and lower miscarriage rate. These authors speculate that motile sperm randomly taken from the epididymis have lower reproductive potential than random sperm taken from the testicle, and argue that the prolonged presence of sperm within the epididymis may lead to structural chromosomal aberrations that can compromise the reproductive potential of the such cells (59). To corroborate these findings, recent studies have demonstrated that epididymal sperm exhibit more DNA damage than sperm retrieved directly from the testis.…”

Section: Impact Of Gamete Source (Epididymis or Testicle) On Reproducmentioning

confidence: 99%

Predictive factors for sperm retrieval and sperm injection outcomes in obstructive azoospermia: Do etiology, retrieval techniques and gamete source play a role?

Miyaoka¹,

Esteves²

2013

Clinics

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Obstructive azoospermia is a relatively common male infertility condition. The main etiologies of obstructive azoospermia include congenital, surgical-derived, traumatic and post-infectious cases. Although seminal tract reconstruction is a cost-effective treatment in most cases, this approach may not be feasible or desired in some cases. In such cases, assisted reproduction techniques offer a method for achieving pregnancy, notably via sperm retrieval and intracytoplasmic sperm injection. This process requires several considerations and decisions to be made, including the cause and duration of obstruction, which sperm retrieval technique to use, and whether to use fresh or frozen-thawed sperm. We present a review of obstructive azoospermia and assisted reproduction techniques, highlighting the most relevant aspects of the decision-making process for use in clinical practice.

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“…post-thaw outcomes. The immaturity of spermatozoa may affect embryo development (25,26), resulting in a lower number of good-quality embryos selected for cryopreservation. However, because those embryos were selected for cryopreservation, indicating a high development rate in in-vitro conditions, such embryos may provide good results in a future freeze-thaw cycle.…”

Section: Figurementioning

confidence: 99%