A comparison of post-thaw results between embryos arising from intracytoplasmic sperm injection using surgically retrieved or ejaculated spermatozoa

Figueira, Rita de Cássia Sávio; Madaschi, Camila; Nichi, Marcílio; Rodrigues, Débora; Pasqualotto, Fábio Firmbach; Iaconelli, Assumpto; Borges, Edson

doi:10.1016/j.fertnstert.2007.12.063

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…Viability of each embryo transferred depends on the biological quality of the oocyte and the spermatozoon at the given embryo's origin [33]. The paternal contributions to early embryo development have been shown to be responsible for repeated failures of assisted reproduction attempts [8], [34].…”

Section: Discussionmentioning

confidence: 99%

“…The paternal contributions to early embryo development have been shown to be responsible for repeated failures of assisted reproduction attempts [8], [34]. The FETs from epididymal and testicular sperm have been shown to have similar clinical results [33]. The abnormalities of sperm parameter, however, have been shown to have negative impact on the clinical result of FET [19].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Sperm DNA Fragmentation on Clinical Outcome of Frozen-Thawed Embryo Transfer and on Blastocyst Formation

Xiao

Qiu

et al. 2014

PLoS ONE

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During the last decades, many studies have shown the possible influence of sperm DNA fragmentation on assisted reproductive technique outcomes. However, little is known about the impact of sperm DNA fragmentation on the clinical outcome of frozen-thawed embryo transfer (FET) from cycles of conventional in vitro fertilization (IVF) and intra-cytoplasmic sperm injection (ICSI). In the present study, the relationship between sperm DNA fragmentation (SDF) and FET clinical outcomes in IVF and ICSI cycles was analyzed. A total of 1082 FET cycles with cleavage stage embryos (C-FET) (855 from IVF and 227 from ICSI) and 653 frozen-thawed blastocyst transfer cycles (B-FET) (525 from IVF and 128 from ICSI) were included. There was no significant change in clinical pregnancy, biochemical pregnancy and miscarriage rates in the group with a SDF >30% compared with the group with a SDF ≤30% in IVF and ICSI cycles with C-FET or B-FET. Also, there was no significant impact on the FET clinic outcome in IVF and ICSI when different values of SDF (such as 10%, 20%, 25%, 35%, and 40%) were taken as proposed threshold levels. However, the blastulation rates were significantly higher in the SDF ≤30% group in ICSI cycle. Taken together, our data show that sperm DNA fragmentation measured by Sperm Chromatin Dispersion (SCD) test is not associated with clinical outcome of FET in IVF and ICSI. Nonetheless, SDF is related to the blastocyst formation in ICSI cycles.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Sperm DNA Fragmentation on Clinical Outcome of Frozen-Thawed Embryo Transfer and on Blastocyst Formation

Xiao

Qiu

et al. 2014

PLoS ONE

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“…As men with azoospermia are often faced with a decision regarding whether or not to undergo a surgical sperm retrieval to facilitate IVF with autologous sperm, additional data regarding IVF cycle outcomes using surgically acquired sperm may be helpful in guiding their counseling and decision-making. To our knowledge, only a few single-center studies have been published detailing the outcomes among cycles using surgically acquired sperm [2][3][4][5][6], particularly in comparison to those using ejaculated sperm [7,8], among men with male factor infertility. Some of these studies specifically investigated outcomes among cycles for which sperm was acquired from either the epididymis [9][10][11][12] or the testes [10,[13][14][15][16][17][18][19][20], but were limited by small sample size.…”

Section: Introductionmentioning

confidence: 99%

Surgically acquired sperm use for assisted reproductive technology: trends and perinatal outcomes, USA, 2004–2015

Kawwass

Chang

Boulet

et al. 2018

J Assist Reprod Genet

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An Inclusive Ethics for the Twenty‐first Century: Implications for Stem Cell Research

Kilner¹

2009

Journal of Religious Ethics

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An important contribution of Christian ethics in the pluralistic world of the twenty‐first century is to emphasize inclusivity. Rather than promoting the interests of certain groups at the expense of the most vulnerable, society does well to prioritize ways forward that benefit all. For stem cell research, inclusivity entails benefiting or at least protecting the beneficiaries of treatment, the sources of materials, and the subjects of research. Adult stem cells are already benefiting many ill patients without causing harm, and select adult cells may prove even more beneficial in the future. Other types of stem cells require other bodily materials such as eggs and somatic cells that should be obtained without unduly harming those who provide them. Research subjects, especially the most vulnerable, require protection as well. Should human embryos be included among them? Considerations of location, formation, individuation, and intention are here examined. Ultimately, for safety reasons as well as workability, pluripotency, and compatibility, relatively new types of pluripotent stem cells, especially induced pluripotent stem cells, warrant special priority according to an inclusive ethics.

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A comparison of post-thaw results between embryos arising from intracytoplasmic sperm injection using surgically retrieved or ejaculated spermatozoa

Cited by 4 publications

References 26 publications

Effect of Sperm DNA Fragmentation on Clinical Outcome of Frozen-Thawed Embryo Transfer and on Blastocyst Formation

Effect of Sperm DNA Fragmentation on Clinical Outcome of Frozen-Thawed Embryo Transfer and on Blastocyst Formation

Surgically acquired sperm use for assisted reproductive technology: trends and perinatal outcomes, USA, 2004–2015

An Inclusive Ethics for the Twenty‐first Century: Implications for Stem Cell Research

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