Embryonic development of GABAergic signaling in the mouse spinal trigeminal nucleus interpolaris

Influence of Temperature on Motor Behaviors in Newborn Opossums (Monodelphis domestica): AnIn VitroStudy

“…For example, in in vitro preparations of rats aged E16 to P6, trigeminal nerve stimulations point to an excitatory action of GABA in neurons of the principal trigeminal nuclei, an effect peaking around E20 and P1 (Waite et al, 2000). An immunohistochemical study of the distribution of different proteins linked to the GABA physiology, glutamic acid decarboxylase, vesicular GABA transporter, KCC2, in the interpolaris part of the spinal trigeminal nucleus in embryonic mice led Kin et al (2014) to suggest that the switch occurs between E13 and E17 in this species. The expression of KCC2 and NKCC1 in the opossum’s spinal cord indicates that the development of inhibition in this species is broadly comparable to that in rodents (Phan and Pflieger, 2013).…”