Embryonic development of GABAergic terminals in the mouse hypothalamic nuclei involved in feeding behavior

Kobayashi, Masato; Shimizu-Okabe, Chigusa; Kim, Jeong-Tae; Kobayashi, Shiori; Matsushita, Masayuki; Masuzaki, Hiroaki; Takayama, Chitoshi

doi:10.1016/j.neures.2017.11.007

Cited by 6 publications

(3 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with this embryonic window of GABA expression, Gad1 has been detected in the ventral anterior hypothalamus as early as E16 (Shimogori et al., ), and it is likely that the SCN displays postnatal increases in GAD expression similar to that reported for other hypothalamic regions (Popp, Urbach, Witte & Frahm, ; Puymirat, Faivre‐Bauman, Bizzini & Tixier‐Vidal, ). Furthermore, Vgat can be detected at low levels in the SCN at E18.5 (Allen Brain Atlas), which is consistent with the timing of Vgat expression in the mediobasal hypothalamus (Kobayashi et al, ). After birth, there is a large increase in SCN Vgat expression over the postnatal period of synaptogenesis (Allen Brain Atlas).…”

Section: Scn Network Developmentsupporting

confidence: 75%

Circuit development in the master clock network of mammals

Carmona‐Alcocer

Rohr

Joye

et al. 2018

Eur J of Neuroscience

View full text Add to dashboard Cite

Daily rhythms are generated by the circadian timekeeping system, which is orchestrated by the master circadian clock in the suprachiasmatic nucleus (SCN) of mammals. Circadian timekeeping is endogenous and does not require exposure to external cues during development. Nevertheless, the circadian system is not fully formed at birth in many mammalian species and it is important to understand how SCN development can affect the function of the circadian system in adulthood. The purpose of the current review is to discuss the ontogeny of cellular and circuit function in the SCN, with a focus on work performed in model rodent species (i.e., mouse, rat, and hamster). Particular emphasis is placed on the spatial and temporal patterns of SCN development that may contribute to the function of the master clock during adulthood. Additional work aimed at decoding the mechanisms that guide circadian development is expected to provide a solid foundation upon which to better understand the sources and factors contributing to aberrant maturation of clock function.

show abstract

Section: Scn Network Developmentsupporting

confidence: 75%

Circuit development in the master clock network of mammals

Carmona‐Alcocer

Rohr

Joye

et al. 2018

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

“…It has been shown in sheep that caloric restriction during pregnancy caused maternal hypoglycemia [61]. The ventromedial hypothalamic nucleus, whose GABAergic network is not fully developed before birth [62], has glucose-sensing neurons, which have been shown to be blunted by hypoglycemic episodes [63] and modulated by 17β-estradiol [64]. One might infer that glucose-sensing neurons in the ventromedial nucleus may be involved in the distinct responses to IUGR between genders.…”

Section: Discussionmentioning

confidence: 99%

A proteomics–metabolomics approach indicates changes in hypothalamic glutamate–GABA metabolism of adult female rats submitted to intrauterine growth restriction

et al. 2018

View full text Add to dashboard Cite

PurposeIntrauterine growth restriction (IUGR) has been shown to induce the programming of metabolic disturbances and obesity, associated with hypothalamic derangements. The present study aimed at investigating the effects of IUGR on the protein and metabolite profiles of the hypothalamus of adult female rats.MethodsWistar rats were mated and either had ad libitum access to food (control group) or received only 50% of the control intake (restricted group) during the whole pregnancy. Both groups ate ad libitum throughout lactation. At 4 months of age, the control and restricted female offspring was euthanized for blood and tissues collection. The hypothalami were processed for data independent acquisition mass spectrometry-based proteomics or targeted mass spectrometry-based metabolomics.ResultsThe adult females submitted to IUGR showed increased glycemia and body adiposity, with normal body weight and food intake. IUGR modulated significantly 28 hypothalamic proteins and 7 hypothalamic metabolites. The effects of IUGR on hypothalamic proteins and metabolites included downregulation of glutamine synthetase, glutamate decarboxylase, glutamate dehydrogenase, isocitrate dehydrogenase, α-ketoglutarate, and up-regulation of NADH dehydrogenase and phosphoenolpyruvate. Integrated pathway analysis indicated that IUGR affected GABAergic synapse, glutamate metabolism, and TCA cycle, highly interconnected pathways whose derangement has potentially multiple consequences.ConclusionThe present findings suggested that the effects of IUGR on GABA/glutamate–glutamine cycle may be involved in the programming of obesity and hyperglycemia in female rats.Electronic supplementary materialThe online version of this article (10.1007/s00394-018-1851-6) contains supplementary material, which is available to authorized users.

show abstract

“…During the development time, GABAergic maturation also has gone through a critical function switch. Within four appetite related centers in the hypothalamus, namely ARC, LHA, PVH and VMH, Kobayashi and his colleagues have demonstrated that upon K + -Cl − -cotransporter 2 (KCC2)- which is responsible for GABA action shifts from excitatory to inhibitory, GABAergic neurons mature first in the LHA, followed by PVH before birth, while VMH and ARC GABA neurons do after birth [ 45 ]. In preclinical studies, it has observed that diet can lead to alteration in reward signaling and in inhibitory neurotransmission control by GABA [ 46 , 47 ].…”

Section: Dmh Gabaergic Neurons In Feeding Regulationmentioning

confidence: 99%

Hypothalamic GABAergic neurocircuitry in the regulation of energy homeostasis and sleep/wake control

Jiang

2022

Medical Review

View full text Add to dashboard Cite

Gamma-aminobutyric acid (GABAergic) neuron, as one of important cell types in synaptic transmission, has been widely involved in central nervous system (CNS) regulation of organismal physiologies including cognition, emotion, arousal and reward. However, upon their distribution in various brain regions, effects of GABAergic neurons in the brain are very diverse. In current report, we will present an overview of the role of GABAergic mediated inhibitory neurocircuitry in the hypothalamus, underlying mechanism of feeding and sleep homeostasis as well as the characteristics of latest transcriptome profile in order to call attention to the GABAergic system as potentially a promising pharmaceutical intervention or a deep brain stimulation target in eating and sleep disorders.

show abstract

Embryonic development of GABAergic terminals in the mouse hypothalamic nuclei involved in feeding behavior

Cited by 6 publications

References 59 publications

Circuit development in the master clock network of mammals

Circuit development in the master clock network of mammals

A proteomics–metabolomics approach indicates changes in hypothalamic glutamate–GABA metabolism of adult female rats submitted to intrauterine growth restriction

Hypothalamic GABAergic neurocircuitry in the regulation of energy homeostasis and sleep/wake control

Contact Info

Product

Resources

About