Embryonal rhabdomyosarcoma (botryoid type) of the vagina

Hilgers, Robert D.; Malkasian, George D.; Soule, Edward H.

doi:10.1016/0002-9378(70)90581-8

Cited by 76 publications

(7 citation statements)

References 62 publications

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“…The mode of management of cervical RMS has significantly changed over the past 20 years. In 1970, Hilgers et al [15] recommended that pelvic exenteration as the best treatment for vaginal RMS. The major surgical treatment for RMS which was performed in our first patient consisted of complete resection of the primary tumor with a surrounding "margin" of normal tissue.…”

Section: Discussionmentioning

confidence: 99%

Embryonal Rhabdomyosarcoma of the Uterine Cervix: Two Cases Report and Literature Review

Khlifi¹,

Asma²,

Kouira³

et al. 2014

OJOG

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Introduction: Embryonal rhabdomyosarcoma (RMS) of the uterine cervix is a rare and extremely aggressive malignant entity. However, prognosis seems to be improved with the use of multimodality approach treatment. Cases: We report the cases of 50-and 51-year-old women, presenting with vaginal bleeding and mass. The two patients underwent radical surgery. Histological examination revealed RMS of uterine cervix. Treatment was effective in the first case but despite the chemotherapy, the second patient died two months later. Discussion and Conclusions: The prognosis of the cervical embryonal RMS depends on clinical and histological features. The current treatment protocols are based on trials done on pediatric patients. Studies on embryonal RMS treatment and outcomes are limited in women over forty years. In patients with unfavorable prognosis characteristics, the multimodality approach including surgery, adjuvant chemo and radiotherapy can be effective. Otherwise, surgery alone can effectively be proposed.

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Section: Discussionmentioning

confidence: 99%

Embryonal Rhabdomyosarcoma of the Uterine Cervix: Two Cases Report and Literature Review

Khlifi¹,

Asma²,

Kouira³

et al. 2014

OJOG

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“…Still rare, the most common type of leiomyosarcoma is the embryonal rhabdomyosarcoma. 5 Vaginal tumors may invade locally and disseminate by several routes: direct extension to pelvic soft tissue structures, lymphatic spread and hematogenous dissemination, depending on the stage and histological type. The most important variable affecting the prognosis is the stage at the time of presentation.…”

Section: Introductionmentioning

confidence: 99%

When an Unexpected Diagnosis Occurs: a Vaginal Premenopausal Sarcoma

Marcos-Figueiredo

Moreira

Morim³

et al. 2018

Rev Bras Ginecol Obstet

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Vaginal cancer is a rare entity. The evidence on its management resides mostly in clinical cases or small case series. Of the histological types, the most frequent is the squamous cell carcinoma, followed by adenocarcinoma. But what to do when identifying an even more infrequent sarcoma in a premenopausal woman? In this study, we describe the case of a 53-year-old woman presenting with metrorrhagia for two months, who was evaluated after an intense episode. A necrotic and ulcerative vaginal swelling was documented and then submitted to biopsy, which revealed a vaginal sarcoma. The patient was referred to radiation therapy with 50 Gy (aiming to control the symptoms and to cause tumor reduction for posterior pelvic exenteration with intraoperative radiotherapy) and developed an extra-pelvic metastization at the end of the treatment, which caused a fast negative outcome. Despite the initial poor prognosis, a chemo-irradiation or primary surgery regimen might have achieved (although with greater side effects) a better survival. This case-report entails a discussion about the strategies to manage vaginal sarcoma in advanced stage and in premenopausal women. Palabras ClaveResumo O cancro vaginal é uma doença rara. A evidência para a sua abordagem reside fundamentalmente em casos clínicos ou pequenas séries de casos. Dentre os tipos de cancro histológicos, o mais frequente é o carcinoma espinocelular, seguido do adenocarcinoma. Mas o que fazer em presença de um sarcoma ainda mais raro numa mulher pré-menopáusica? No presente estudo, descrevemos o caso de uma mulher de 53 anos apresentando metrorragia por dois meses, avaliada após um episódio intenso. Foi então documentada uma tumefacção vaginal necrótica e ulcerativa, submetida a biópsia, que revelou um sarcoma vaginal. A paciente foi encaminhada para radioterapia

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“…Survival management has changed significantly over the past 20 years. Hilgers et al in 1970 recommended that vaginal RMS was best treated by pelvic exenteration [9]. The addition of adjuvant chemotherapy makes a substantial contribution to the improvement in survival [10].…”

Section: Introductionmentioning

confidence: 99%