Embryo transfer strategy and therapeutic options in infertile patients with thin endometrium: a systematic review

Ranisavljevic, Noémie; Raad, J.; Anahory, T.; Grynberg, Michaël; Sonigo, Charlotte

doi:10.1007/s10815-019-01576-w

Cited by 41 publications

(30 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Embryo implantation failure caused by the thin endometrium is a serious challenge for assisted reproductive technology, especially since there is no established effective treatment for this condition. In recent years, long-term administration of estrogen, vaginal sildenafil, low-dose aspirin, pentoxifylline, autologous platelet-rich plasma, intrauterine perfusion of G-CSF, and other treatments have been used to treat thin endometrium; however, providing effective evidence-based interventions continues to pose a significant challenge [8,[35][36][37]. Therefore, alternative treatments are needed for patients with thin endometrium.…”

Section: Discussionmentioning

confidence: 99%

“…Several interventions have been explored to improve endometrial thickness, such as luteal estradiol, granulocyte colony-stimulating factor (G-CSF), intrauterine infusion of platelet-rich plasma, and treatments that improve uterine blood flow [8]. Thus far, for patients with a thin endometrium, insufficient specific treatments have been clinically used to increase pregnancy or live birth rates [6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electroacupuncture Improves Pregnancy Outcomes in Rats with Thin Endometrium by Promoting the Expression of Pinopode-Related Molecules

Cheng

Jin

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

A thin endometrium affects the success of assisted reproduction due to low endometrial receptivity. Acupuncture improves endometrial receptivity and promotes the formation of pinopodes, the ultrastructure marker implantation window. However, the specific underlying mechanisms remain unclear. In this study, the efficacy of acupuncture treatment and its underlying mechanism were investigated by analyzing pregnancy rate, pinopode formation, and related molecular markers in thin endometrium model rats. Absolute ethanol (95%) was injected into the uteruses of female Sprague-Dawley rats to construct a thin endometrium model. In this model, acupuncture stimulation at EX-CA1, SP6, and CV4 ameliorated the pregnancy rate. Significantly increased embryo implantation, endometrial thickness, numbers of glands, and blood vessels were observed in the electroacupuncture (EA) group compared to the model group. The number of pinopodes in the EA group was abundant, with a shape similar to that of the control group. Additionally, significantly higher expression levels of pinopode-related markers, including integrin αvβ3, homeobox A10 (HOXA10), heparin-binding EGF-like growth factor (HBEGF), estrogen receptor alpha (ERα), and progesterone receptor (PR), were observed in the EA group than those in the model group. In conclusion, EA had a positive effect on the endometrial receptivity of thin endometrium model rats by improving pinopode formation through multiple molecular targets.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electroacupuncture Improves Pregnancy Outcomes in Rats with Thin Endometrium by Promoting the Expression of Pinopode-Related Molecules

Cheng

Jin

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…A previous trial showed that PRP efficiently improved the endometrium proliferation, implantation rate, and clinical pregnancy rate [ 48 ]; however, clinical trial data is limited, with the majority being non-randomized trials [ 49 ]. A systematic review indicates that only a few randomized controlled trials support the use of sildenafil in frozen embryo transfer (ET) for enhancing endometrial growth [ 50 ]. Other treatments, such as vitamin E and l-arginine, were all base on small sample size, thus lack sufficient evidence of efficacy [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of electroacupuncture for thin endometrium in infertile women: study protocol for a single-blind, randomized controlled trial

Wang

et al. 2021

Trials

View full text Add to dashboard Cite

Background Thin endometrium negatively impacts the reproductive function. Current treatments for thin endometrium do not always improve endometrial receptivity. Preliminary evidence suggests that electroacupuncture could have potential therapy for thin endometrium in infertile women. Thus, this randomized controlled trial was designed to test whether electroacupuncture can improve endometrial receptivity in infertile women with thin endometrium. Methods This study is a randomized, single-blinded, controlled, clinical trial. A total of 142 eligible patients will be recruited and randomly assigned to the electroacupuncture (EA) group or the sham electroacupuncture (SEA) group in a 1:1 ratio. Participants will receive 36 sessions over three menstrual cycles (12 weeks in total), with the same acupoint prescription. The primary outcome of this trial is endometrial thickness in the midluteal phase. The secondary outcomes include endometrial pattern, resistance index (RI) and pulsatility index (PI) of bilateral uterine artery and endometrium blood flow, serum estradiol (E2) and progesterone (P), and pregnancy rate. The pregnancy rate will be evaluated during a 6-month follow-up after completion of the trial. All other outcomes will be evaluated before treatment, during the treatment of 1st, 2nd, and 3rd menstrual cycle, and 6 months after treatment. Discussion If the outcome confirms the effectiveness of electroacupuncture for thin endometrium in infertile women, this treatment will be proposed for application in clinical practice. Trial registration Chinese Clinical Trials Registry ChiCTR2000029983. Registered on 18 February 2020

show abstract

“…Several strategies have been proposed to manage thin endometrium in FET cycles, including modification of E 2 use (149)(150)(151), in-utero administration of granulocyte colony stimulating factor (152), in-utero administration of plateletrich plasma (153), vaginal sildenafil (154), oral pentoxyfiline, oral tocopherol (155), oral aspirin (156) or pelvic floor neuromuscular electrical stimulation (157). However, none of these strategies have been unequivocally proven to be of benefit in patients with thin endometrium (158).…”

Section: Endometrial Thickness and Thin Endometriummentioning

confidence: 99%

Preparation of the Endometrium for Frozen Embryo Transfer: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

Despite the worldwide increase in frozen embryo transfer, the search for the best protocol to prime endometrium continues. Well-designed trials comparing various frozen embryo transfer protocols in terms of live birth rates, maternal, obstetric and neonatal outcome are urgently required. Currently, low-quality evidence indicates that, natural cycle, either true natural cycle or modified natural cycle, is superior to hormone replacement treatment protocol. Regarding warmed blastocyst transfer and frozen embryo transfer timing, the evidence suggests the 6th day of progesterone start, LH surge+6 day and hCG+7 day in hormone replacement treatment, true natural cycle and modified natural cycle protocols, respectively. Time corrections, due to inter-personal differences in the window of implantation or day of vitrification (day 5 or 6), should be explored further. Recently available evidence clearly indicates that, in hormone replacement treatment and natural cycles, there might be marked inter-personal variation in serum progesterone levels with an impact on reproductive outcomes, despite the use of the same dose and route of progesterone administration. The place of progesterone rescue protocols in patients with low serum progesterone levels one day prior to warmed blastocyst transfer in hormone replacement treatment and natural cycles is likely to be intensively explored in near future.

show abstract

Embryo transfer strategy and therapeutic options in infertile patients with thin endometrium: a systematic review

Cited by 41 publications

References 77 publications

Electroacupuncture Improves Pregnancy Outcomes in Rats with Thin Endometrium by Promoting the Expression of Pinopode-Related Molecules

Electroacupuncture Improves Pregnancy Outcomes in Rats with Thin Endometrium by Promoting the Expression of Pinopode-Related Molecules

Effectiveness of electroacupuncture for thin endometrium in infertile women: study protocol for a single-blind, randomized controlled trial

Preparation of the Endometrium for Frozen Embryo Transfer: A Systematic Review

Contact Info

Product

Resources

About