Embryo transfer following in vitro maturation and cryopreservation of oocytes recovered from antral follicles during conservative surgery for ovarian cancer

Fadini, Rubens; Canto, Mariabeatrice Dal; Renzini, Mario Mignini; Milani, Rodolfo; Fruscio, Robert; Cantù, Maria Grazia; Brambillasca, Fausta; Coticchio, Giovanni

doi:10.1007/s10815-012-9768-0

Cited by 37 publications

(29 citation statements)

References 12 publications

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“…Additionally, oocyte survival was decreased in in vitro matured (67.5 %) compared to in vivo matured oocytes (81.4 %; [37]). To date, only a few live births have been reported from cryopreserved IVM oocytes [38][39][40]. In a study reporting on 39 oocytes retrieved during the OTC process and matured invitro, Imesh et al [13] reported a survival rate of 61.5 % after vitrification/warming.…”

Section: Discussionmentioning

confidence: 99%

In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising “ex vivo” method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe

Segers¹,

Mateizel²,

Moer³

et al. 2015

J Assist Reprod Genet

128

105

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Section: Discussionmentioning

confidence: 99%

In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising “ex vivo” method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe

Segers¹,

Mateizel²,

Moer³

et al. 2015

J Assist Reprod Genet

128

105

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show abstract

“…Recently, we published a case report [82] that offers the proof-of-principle of the possibility to associate oocyte IVM and cryopreservation. The case involved the recovery of immature oocytes from antral follicles during a laparotomic conservative surgery for ovarian cancer.…”

Section: Cryopreservation Of Immature Oocytes Obtained From Ivm Cyclesmentioning

confidence: 99%

The current challenges to efficient immature oocyte cryopreservation

Brambillasca

Guglielmo

Coticchio

et al. 2013

J Assist Reprod Genet

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Oocyte cryopreservation represents an important tool for assisted reproductive technology. It offers the opportunity to preserve fertility in women at risk of loss of the ovarian function for various pathologies. It also represents a treatment alternative for couples that cannot benefit from embryo cryopreservation because of moral, religious, or legal constrains. On the other hand, in vitro oocyte maturation has a range of applications. It can be applied in patients with a contraindication to ovarian stimulation to prevent ovarian hyperstimulation syndrome or to eliminate the risk of stimulation of hormone-sensitive tumours in cancer patients. However, while mature oocyte cryopreservation has found widespread application and oocyte in vitro maturation has a place for the treatment of specific clinical conditions, data on the efficiency of freezing of immature or in vitro matured oocytes are poorer. In this review we will focus on the combination of oocyte in vitro maturation with oocyte cryopreservation with particular emphasis on the biological implications of the cryopreservation of immature or in vitro matured oocytes. The two cryopreservation approaches, slow freezing and vitrification, will be discussed in relation to possible cryodamage occurring to subcellular structures of the oocyte and the functional interaction between oocyte and cumulus cells.

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“…To date, five case reports of oocyte retrieval from a tumor-affected ovary during laparotomic oophorectomy have been published [23456]. However, this is the first case in which a random-start COS protocol was applied in an ovarian cancer patient who required debulking surgery (Table 1) [23456].…”

Section: Discussionmentioning

confidence: 99%

“…However, this is the first case in which a random-start COS protocol was applied in an ovarian cancer patient who required debulking surgery (Table 1) [23456]. …”

Section: Discussionmentioning

confidence: 99%

“…There are cases where the follicle is near the tumor making aspiration difficult, or where the tumor mass is near the vagina in the way of aspiration. In contrast, during a debulking operation for ovarian cancer, careful oocyte retrieval using a laparotomic approach can be performed without penetrating the tumor and without causing cancer cell spillage [23456]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mature oocyte retrieval during laparotomic debulking surgery following random-start controlled ovarian stimulation for fertility preservation in a patient with suspected ovarian cancer

Kim

et al. 2015

Obstet Gynecol Sci

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Herein, we report a case of successful mature oocyte retrieval during laparotomy after random-start controlled ovarian stimulation (COS) in a 21-year-old nulliparous woman with suspected recurrent ovarian immature teratoma. The patient had been diagnosed with stage IIIC immature teratoma two years earlier following a staging operation, including right oophorectomy and left ovarian cystectomy. And she had subsequently undergone four rounds of postoperative adjuvant chemotherapy with bleomycin, etoposide, and cisplatin. Approximately two years after the initial surgery, she was strongly suspected of having recurrent ovarian immature teratoma on radiologic follow-up. We performed random-start COS and in vivo oocyte retrieval during laparotomic debulking surgery including left oophorectomy. Eight mature oocytes were successfully retrieved and vitrified for fertility preservation. The final pathologic diagnosis was mature cystic teratoma of the ovary and peritoneal implants consistent with gliomatosis peritonei. This is the first case report in which random-start COS and in vivo oocyte retrieval were performed.

show abstract

Embryo transfer following in vitro maturation and cryopreservation of oocytes recovered from antral follicles during conservative surgery for ovarian cancer

Cited by 37 publications

References 12 publications

In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising “ex vivo” method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe

In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising “ex vivo” method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe

The current challenges to efficient immature oocyte cryopreservation

Mature oocyte retrieval during laparotomic debulking surgery following random-start controlled ovarian stimulation for fertility preservation in a patient with suspected ovarian cancer

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