Embryo‐fetal developmental toxicity study design for pharmaceuticals

Wise, L. David; Buschmann, J.; Feuston, Maureen H.; Fisher, J. Edward; Hew, Kok Wah; Hoberman, Alan M.; Lerman, Sidney; Ooshima, Yôjiro; Stump, Donald G.

doi:10.1002/bdrb.20214

Cited by 54 publications

(31 citation statements)

References 40 publications

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“…The mouse is a common mammalian model for embryonic toxicity studies [Bailey et al, 2009;Wise et al, 2009;Khan et al, 2013;Wolff et al, 2013]. Because NP can cross the placental barrier in mammals and can accumulate in embryonic as well as surrounding extra-embryonic tissues, studying their effect on embryos is critical [Chu et al, 2010].…”

Section: Embryonic Toxicity Of Np In Animal Models: Mammalian Embryosmentioning

confidence: 99%

Embryonic Toxicity of Nanoparticles

Celá

Veselá

Matalová

et al. 2014

Cells Tissues Organs

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Applications of nanoparticles (NP) in medicine, industry and other branches of human activities undoubtedly contribute to technology development and well-being. However, as NP are very small units in a wide range of materials, there is a lack of information related to possible side effects potentially affecting the health of organisms. There is increasing experimental interest in the determination of environmental effects on humans exposed to NP. Most such experimental studies focus on adult populations or adult experimental animals. However, embryos can be more sensitive to pollutants and environmental impacts in some species. Therefore, some investigations dealing particularly with the effects of NP on embryonic development have appeared recently and this issue is becoming of great concern. The aim of this review is to summarize the knowledge on the effects of various nanomaterials on embryonic development. A comprehensive collection of significant experimental nanotoxicity data is presented, which also indicate how the toxic effect of NP can be mediated and modulated with respect to possible effective protection strategies.

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Section: Embryonic Toxicity Of Np In Animal Models: Mammalian Embryosmentioning

confidence: 99%

Embryonic Toxicity of Nanoparticles

Celá

Veselá

Matalová

et al. 2014

Cells Tissues Organs

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“…M. Parker 2014a, 2012; R. M. Parker and York 2013; Wise et al 2009; York et al 2014), and juvenile toxicology (Bailey and Mariën 2011; Cappon 2011; Cappon et al 2009; Carleer and Karres 2011; Hurtt 2011; Leconte et al 2011; R. M. Parker 2014b; Rose 2011; Shimomura 2011; Tassinari et al 2011).…”

Section: Opening Remarks and Clinical Regulatory And Toxicology Permentioning

confidence: 99%

Juvenile Toxicology

Remick¹,

Catlin

Quist

et al. 2015

Toxicol Pathol

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The Society of Toxicologic Pathology (STP) Education Committee and the STP Reproductive Special Interest Group held a North Carolina regional meeting entitled, “Juvenile Toxicology: Relevance and Challenges for Toxicologists and Pathologists” on March 13, 2015, at the National Institute of Environmental Health Sciences/National Toxicology Program in Research Triangle Park, North Carolina. The purpose of this regional meeting was to familiarize attendees with the topic of juvenile toxicity testing and discuss its relevance to clinical pediatric medicine, regulatory perspectives, challenges of appropriate study design confronted by toxicologists, and challenges of histopathologic examination and interpretation of juvenile tissues faced by pathologists. The 1-day meeting was a success with over 60 attendees representing industry, government, research organizations, and academia.

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“…Additional guidelines address the need and design of juvenile toxicity (from birth until after sexual maturity) studies. Wise's talk detailed the design and types of data collected in the embryo–fetal studies in rodents and rabbits 42 . Although labor intensive, these studies provide the most suitable data for determining risk information for women of childbearing age.…”

Section: Session Vii: Environment Hormone Action and Pharmacologicamentioning

confidence: 99%

Fetal programming and environmental exposures: implications for prenatal care and preterm birth

Schug

Erlebacher

Leibowitz

et al. 2012

Annals of the New York Academy of Sciences

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Sponsored by the New York Academy of Sciences and Cincinnati Children's Hospital Medical Center, with support from the National Institute of Environmental Health Sciences (NIEHS), the National Institute on Drug Abuse (NIDA), and Life Technologies, “Fetal Programming and Environmental Exposures: Implications for Prenatal Care and Preterm Birth” was held on June 11–12, 2012 at the New York Academy of Sciences in New York City. The meeting, comprising individual talks and panel discussions, highlighted basic, clinical, and translational research approaches, and highlighted the need for specialized testing of drugs, consumer products, and industrial chemicals, with a view to the unique impacts these can have during gestation. Speakers went on to discuss many other factors that affect prenatal development, from genetics to parental diet, revealing the extraordinary sensitivity of the developing fetus.

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Embryo‐fetal developmental toxicity study design for pharmaceuticals

Cited by 54 publications

References 40 publications

Embryonic Toxicity of Nanoparticles

Embryonic Toxicity of Nanoparticles

Juvenile Toxicology

Fetal programming and environmental exposures: implications for prenatal care and preterm birth

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