Embryo and fetotoxicity of hexavalent chromium: a long-term study

Kanojia, Raj Kamal; Junaid, Mohammad; Murthy, Ramesh

doi:10.1016/s0378-4274(98)00034-4

Cited by 88 publications

(49 citation statements)

References 17 publications

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“…U kobiet zawodowo narażonych na działanie chromu stwierdzono upośledzenia dojrzewania płodu oraz komplikacje podczas ciąży i porodu (53).…”

Section: Chrom W Badaniach Na Zwierzętach I Ludziachunclassified

“…U samic przyjmujących Cr zaobserwowano znaczący wzrost masy jajników, podczas gdy masa macicy uległa znacznemu zmniejszeniu (34). Ekspozycja samicy myszy na Cr skutkowała mniejszą liczbą implantacji zarodków i tym samym obniżała płodność (53). Wysoka zawartość Cr w łożysku i zwiększenie przechodzenie pierwiastka do płodu bezpośrednio wpływa na struktury embrionu (53).…”

Section: Chrom W Badaniach Na Zwierzętach I Ludziachunclassified

“…Ekspozycja samicy myszy na Cr skutkowała mniejszą liczbą implantacji zarodków i tym samym obniżała płodność (53). Wysoka zawartość Cr w łożysku i zwiększenie przechodzenie pierwiastka do płodu bezpośrednio wpływa na struktury embrionu (53). Podsumowując, chrom może wpływać negatywne na płodność i reprodukcję (34).…”

Section: Chrom W Badaniach Na Zwierzętach I Ludziachunclassified

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Trivalent chromium (CrIII) as a trace element essential for animals and humans

Kosla¹,

Lasocka²,

Skibniewska³

et al. 2018

Medycyna Weterynaryjna

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Trivalent chromium is considered an essential element in the nutrition of both animals and humans. Animal studies confirm many beneficial effects of organic and inorganic chromium compounds on carbohydrate, protein and lipid metabolism in the body. Glucose tolerance factor (GTF) has been demonstrated to involve an active form of trivalent chromium, which sustains normal glucose metabolism. Cr(III) compounds form enzymes and ribonucleic acids, accelerate blood clotting and increase β-glucuronidase activity. Chromium also participates in antioxidant processes, in the synthesis of RNA and DNA and in the immune response, as well as affects secretion of hormones and some vitamins. It has been demonstrated that chromium improves lean body mass in animals, increases growth rate and feed conversion and improves feed intake and energy efficiency. Organic chromium reduces mortality and improves animal reproduction parameters. It also enhances immunity and strengthens response to preventive vaccination. It has been noted in many animal species that a diet low in chromium leads to deficiency symptoms, such as reduced feed intake, lower weight gains, reproductive disorders and increased lipid levels. Chromium deficiency can also result from stress. Moderate chromium deficiency is a risk factor of ischemic heart disease with myocardial infarction. Such a condition may pose a great risk of coronary artery disease. Dietary chromium requirement of an animal body is probably 300 μg Cr/kg d.w. of feed, which is usually satisfied by the ration provided. The highest concentration of chromium is found in the hair, skin and teeth, followed by the liver, kidneys, spleen, and slightly lower in the heart, muscles, pancreas, lungs, bones and brain. Chromium absorption rates in the human intestine range between 0.5 and 2% of the daily intake of inorganic Cr forms, and from 25 to 30% of the element ingested as organic complexes. Clinical studies show that the kinetics of chromium excretion from the system are complex and can be described by a multi-range model, the half-life ranging from 13 min to 192 days. Dietary chromium nanocomposite supplementation (CrNano) used in pigs nutrition has significantly increased Cr content in the blood, longissimus muscle, heart, liver, kidneys, jejunum and ileum. Chromium nanocomposite supplementation acts more effectively on the tissues and, as a consequence, increases the accumulation of the element. .

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“…U kobiet zawodowo narażonych na działanie chromu stwierdzono upośledzenia dojrzewania płodu oraz komplikacje podczas ciąży i porodu (53).…”

Section: Chrom W Badaniach Na Zwierzętach I Ludziachunclassified

See 1 more Smart Citation

Trivalent chromium (CrIII) as a trace element essential for animals and humans

Kosla¹,

Lasocka²,

Skibniewska³

et al. 2018

Medycyna Weterynaryjna

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“…Cr (VI) can traverse the placental barrier in rodents (Tipton and Shafer, 1964;Barceloux, 1999), and within the pregnant uterus Cr (VI) alters early development of blastocyst (Jacquet and Draye, 1982), decreases the number of implantation sites and viable fetuses . ; Kamath et al, 1997;Kanojia et al, 1998), produces embryo-toxic and fetotoxic effects and increase conceptus resorption in rodents.…”

Section: Introductionmentioning

confidence: 99%

“…Chromium exposure via drinking water impairs ovarian follicular maturation and differentiation and promotes follicular atresia , delays puberty, lengthens inter-estrous intervals and reduces numbers of ovulations in rodents (Kanojia et al, 1998). Chromium compounds are toxic, carcinogenic and mutagenic in humans and animals (Langard, 1990).…”

Section: Introductionmentioning

confidence: 99%

Effect of Turmeric Oil in Reproductive Efficiency of Immature Female Rats Exposed to Oxidative Stress Induced by Potassium Dichromate

Jeber¹

2012

IOSJPBS

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Chrom(VI)‐Verbindungen [MAK Value Documentation in German language, 2010]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 48. Lieferung, Ausgabe 2010 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Toxikokinetik Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Bewertung

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Embryo and fetotoxicity of hexavalent chromium: a long-term study

Cited by 88 publications

References 17 publications

Trivalent chromium (CrIII) as a trace element essential for animals and humans

Trivalent chromium (CrIII) as a trace element essential for animals and humans

Effect of Turmeric Oil in Reproductive Efficiency of Immature Female Rats Exposed to Oxidative Stress Induced by Potassium Dichromate

Chrom(VI)‐Verbindungen [MAK Value Documentation in German language, 2010]

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