Effect of Turmeric Oil in Reproductive Efficiency of Immature Female Rats Exposed to Oxidative Stress Induced by Potassium Dichromate

Jeber, Z. Kh.

doi:10.9790/3008-0440913

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…[2][3][4][5][6][7][8] Turmeric (curcumin) exist as a pure crystalline powder which is soluble in organic solutions such as ether, alcohol, and olive oil. 9 The potential therapeutic benefits of turmeric has led to an increase in its consumption globally, 10,11 with several studies showing also the beneficial nephroprotective effect of turmeric, [12][13][14][15] despite this, there is still a noticeable increase in the number of individuals affected by kidney related diseases, most especially chronic kidney disease. 16,17 Chronic kidney disease is characterized by progressive loss in kidney function which affects the excretion of metabolic byproducts 18 .…”

Section: Introductionmentioning

confidence: 99%

Potential Nephrotoxic Sequel of the Kidney Following Exposure to Turmeric Extract in Adult Wistar Rats

Ahama,

Igben,

Ubogu

et al. 2023

J Coll Med Sci-Nepal

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IntroductionTurmeric (Curcuma Longa) is a rhizomatous, perennial plant, flowering in nature, belonging to the ginger family. It’s potential therapeutic benefits, has led to an increase in its consumption globally. Despite severe studies on turmeric there is still existing literature gap on the effect of turmeric on the kidney. This study espoused the potential nephrotoxic sequel of the kidney following exposure to turmeric extract in adult wistar rats. MethodsEthical approval for the study was obtained from the Ethics and Research Committee in the Faculty of Basic Medical Sciences of the Delta State University, Abraka. 24 adult female Wistar rats, weighing between 180g - 200g were used as experimental model. They were grouped into 4 groups (A, B, C and D), and were euthanized at the end of the experimental days and effect of tumeric extract were studied. ResultsWe found that tumeric extract effect on the kidney histology was unremarkable in all groups with varying doses. Also observed was moderate significant increase in creatinine and urea level in treated groups when compared with control group. Conclusions Obtained upshot suggests that oral administration of turmeric with graded doses and time dependent showed no microscopic or cytoarchitectural changes, but with a negative functional report.

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Section: Introductionmentioning

confidence: 99%

Potential Nephrotoxic Sequel of the Kidney Following Exposure to Turmeric Extract in Adult Wistar Rats

Ahama,

Igben,

Ubogu

et al. 2023

J Coll Med Sci-Nepal

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Ameliorative effects of coconut oil on the ovaries of refinery effluent intoxicated Norwegian rats

Ekaye

Uwagie-Ero

Aghayedo

2019

Nig. J. Env. Sci. & Tech.

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The study was conducted to determine the possible ameliorative activity of coconut oil on the toxic effects of untreated refinery effluents on the ovaries of Norwegian rats. Three experimental groups of 10 rats each were used for the study; all animals had feed and water ad libitum. Group 1 was untreated and served as the control group, Group 2 was treated with 2 ml of untreated refinery effluent daily PO and group 3 was treated with 2 ml of untreated refinery effluent and 2 ml of coconut oil daily PO for 9 weeks. Every 3 weeks 2 rats in each group were euthanized with chloroform and ovarian tissues were surgically harvested; tissue concentration of heavy metals was assayed and histology was carried out. Treatment was discontinued at nine weeks and rats in group 2 and 3 were designated groups 4 and 5; allowed a 21 days resting period after which they were euthanized, ovaries surgically harvested and assayed as well. Results indicate that changes in ovarian tissue concentration of Chromium and Lead in the treated groups were of statistical significance (P ≤ 0.05) compared to control. Results also showed that rats treated with coconut oil as abatement had normal histological architecture. Coconut oil had ameliorative effects on the ovary of rats intoxicated with refinery effluent and the ovaries returned to normal activities within 21 days post exposure.

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Effect of Turmeric Oil in Reproductive Efficiency of Immature Female Rats Exposed to Oxidative Stress Induced by Potassium Dichromate

Cited by 2 publications

References 29 publications

Potential Nephrotoxic Sequel of the Kidney Following Exposure to Turmeric Extract in Adult Wistar Rats

Potential Nephrotoxic Sequel of the Kidney Following Exposure to Turmeric Extract in Adult Wistar Rats

Ameliorative effects of coconut oil on the ovaries of refinery effluent intoxicated Norwegian rats

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