Embolization of Arteriovenous Malformations with Onyx: Clinicopathological Experience in 23 Patients

Jahan, Reza; Murayama, Yuichi; Gobin, Y. Pierre; Duckwiler, Gary; Vinters, Harry V.; Viñuela, Fernando

doi:10.1227/00006123-200105000-00003

Cited by 65 publications

(93 citation statements)

References 31 publications

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“…Histopathologic and angiographic studies have shown no evidence of short-term recanalization after Onyx embolization. 8,10 In addition, Onyx appears to have better surgical handling characteristics than cyanoacrylate. 11 Several series have now established a high degree of safety and efficacy of Onyx in the treatment of intracranial AVMs.…”

Section: Discussionmentioning

confidence: 99%

“…11 Several series have now established a high degree of safety and efficacy of Onyx in the treatment of intracranial AVMs. 10,[12][13][14] Our preliminary results with the use of Onyx for the embolization of intracranial DAVFs appear very promising. Complete angiographic cure was seen in 11 of the 12 patients (91.7%), and minor residual supply was left in 1 patient.…”

Section: Discussionmentioning

confidence: 99%

“…12 Angiotoxicity with vasospasm or angionecrosis has also been associated with Onyx embolization due to use of DMSO. 10 The DMSO angiotoxicity is dependent on the volume injected and time in contact with the endothelium. 8 Murayama et al 8 demonstrated that the injection of 0.3 mL for 40 seconds was safe with no histopathologic evidence of angiotoxicity.…”

Section: Discussionmentioning

confidence: 99%

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Preliminary Experience with Onyx Embolization for the Treatment of Intracranial Dural Arteriovenous Fistulas

Nogueira¹,

Dabus²,

Rabinov³

et al. 2007

AJNR Am J Neuroradiol

172

125

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Preliminary Experience with Onyx Embolization for the Treatment of Intracranial Dural Arteriovenous Fistulas

Nogueira¹,

Dabus²,

Rabinov³

et al. 2007

AJNR Am J Neuroradiol

172

125

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“…The copolymer precipitates when coming in contact with blood due to rapid dissipation of DMSO [7]. Onyx has shown great potential in treatment of brain and spinal arteriovenous malformations as well as peripheral arteriovenous malformations [8][9][10]. It has also found increasing use in peripheral interventions such as bleeding due to iatrogenic vessel injury/pseudoaneurysm, aneurysm, malignancy/inflammation, trauma, etc.…”

Section: Discussionmentioning

confidence: 99%

Liquid Embolization with Onyx in a Technically Challenging Case of Acute Upper GI Bleeding

Bharadwaz

Madhab

2013

Indian J Surg

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Conventional embolization such as coiling of acute upper gastrointestinal bleeding may be rendered impossible or unsuitable due to anatomical and technical factors. Liquid (Onyx) embolization in such situations may prove valuable and life saving, though literature on the subject, particularly of acute upper gastrointestinal bleeding due to duodenal ulcer, is sparse. We present a technically challenging case of acutely rebleeding duodenal ulcer embolized successfully using ethylene polyvinyl alcohol polymer (Onyx).

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“…In addition, long-term follow up times (Ͼ 12-24 months) have not been studied adequately for patients treated with Onyx. 13 The majority of patients who receive endovascular treatments still undergo complementary resection or radiosurgery.…”

Section: Discussionmentioning

confidence: 99%

Preoperative silk suture embolization of cerebral and dural arteriovenous malformations

Ar¹,

Muster²,

Reverdin³

et al. 2001

FOC

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Object The aim of this study was to evaluate the use of silk sutures as a medical implant when applied for the embolization of cerebral and dural arteriovenous malformations (AVMs). The facility of surgery and the clinical significance of complications related to preoperative silk suture embolization were evaluated immediately after surgery and at long-term follow up. Methods Thirty-four patients harboring 29 cerebral and five dural AVMs underwent embolization in which silk alone or in association with other agents was used. Medical and radiological records obtained in these 34 patients were reviewed retrospectively. The cerebral AVMs were classified according to the Spetzler–Martin grading system and the dural AVMs to the Djindjian grading system. The facility of the resection and the adverse outcomes, including new neurological deficits, hemorrhage, and fever, as well as histopathological evidence of vessel inflammatory changes, were determined in each case. In all 23 surgical cases, the AVM could be easily manipulated and excised. New temporary neurological deficits occurred in three patients. A high Spetzler–Martin grade was not associated with a higher incidence of new neurological deficits. One delayed-onset hemorrhage was detected after embolization. Fever was present in 24% of the patients. No sign of significant vasculitis or perivascular inflammation was found on radiological or histopathological examination. Conclusions Silk sutures are safe embolic agents especially for proximal occlusion of AVM feeding vessels. New permanent neurological deficits were not encountered in this series. Fever was considered to be a minor, temporary side effect of silk suture embolization.

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Embolization of Arteriovenous Malformations with Onyx: Clinicopathological Experience in 23 Patients

Cited by 65 publications

References 31 publications

Preliminary Experience with Onyx Embolization for the Treatment of Intracranial Dural Arteriovenous Fistulas

Preliminary Experience with Onyx Embolization for the Treatment of Intracranial Dural Arteriovenous Fistulas

Liquid Embolization with Onyx in a Technically Challenging Case of Acute Upper GI Bleeding

Preoperative silk suture embolization of cerebral and dural arteriovenous malformations

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