Abstract:The authors report a case of carotid body tumor (paraganglioma) in a 74-year-old male patient, submitted to intraarterial embolization with spherical core/shield polyvinyl acetate and polyvinyl alcohol (PVAc + PVA) microparticles prior to surgical excision. Angiography has demonstrated a highly vascularized mass in the left carotid bifurcation, and preoperative embolization was used in order to decrease vascularity, reduce blood loss and improve safety of surgical treatment. Microscopic study confirmed presenc… Show more
“…An ideal embolic agent should provide a large number of features;23 however, biocompatibility and non‐carcinogenicity constitute basic requirements for any type of material used in biomedical applications. Although a relatively large number of materials have already been used as embolic agents,18, 19, 24–27 PVA‐based particles are certainly the most frequently used embolic agents, because of their characteristic biocompatibility and performance 19, 28–30. However, commercial PVA grades present some undesirable characteristics (e.g., irregular morphology) that make these commercial PVA grades unsuited for use as embolic agents 21…”
The effects of amoxicillin on the course of vinyl acetate (VAc)/methyl methacrylate (MMA) suspension copolymerizations are analyzed. It is shown that the presence of the drug affects the morphology of the produced particles, although the interfacial tension is insensitive to modification of the drug concentration in the analyzed range (1–3 wt% of the aqueous phase). It is also shown that this drug interacts preferentially with VAc, causing an inhibitory effect on the rate of polymerization and enhancing the characteristic composition drift of VAc/MMA copolymerizations. Finally, it is shown that the presence of the drug leads to significant modifications of the molecular weight distributions of the final polymer material.
“…An ideal embolic agent should provide a large number of features;23 however, biocompatibility and non‐carcinogenicity constitute basic requirements for any type of material used in biomedical applications. Although a relatively large number of materials have already been used as embolic agents,18, 19, 24–27 PVA‐based particles are certainly the most frequently used embolic agents, because of their characteristic biocompatibility and performance 19, 28–30. However, commercial PVA grades present some undesirable characteristics (e.g., irregular morphology) that make these commercial PVA grades unsuited for use as embolic agents 21…”
The effects of amoxicillin on the course of vinyl acetate (VAc)/methyl methacrylate (MMA) suspension copolymerizations are analyzed. It is shown that the presence of the drug affects the morphology of the produced particles, although the interfacial tension is insensitive to modification of the drug concentration in the analyzed range (1–3 wt% of the aqueous phase). It is also shown that this drug interacts preferentially with VAc, causing an inhibitory effect on the rate of polymerization and enhancing the characteristic composition drift of VAc/MMA copolymerizations. Finally, it is shown that the presence of the drug leads to significant modifications of the molecular weight distributions of the final polymer material.
Os autores relatam pela primeira vez utilização de uma nova partícula para embolização, constituída de um núcleo de acetato de polivinil revestido por polivinil-álcool, de forma esférica (Spherus®-First Line Brasil), como preparo pré-operatório em três pacientes portadores de neoplasia renal, na intenção de diminuir o tamanho do tumor e prevenir complicações hemorrágicas durante o ato operatório. Estas novas partículas foram projetadas e elaboradas nos laboratórios da COPPE/UFRJ. A embolização intra-arterial pré-operatória com estas novas partículas ocasionou acentuada isquemia em todo o tecido tumoral facilitando o procedimento cirúrgico.
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