Embedded of Nanogel into Multi-responsive Hydrogel Nanocomposite for Anticancer Drug Delivery

Bardajee, Ghasem Rezanejade; Hosseini, Samaneh Sadat; Ghavami, Somayeh

doi:10.1007/s10904-018-0914-8

Cited by 14 publications

(10 citation statements)

References 33 publications

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“…The unique physicochemical properties of hydrogels such as hydrophilicity greatly contributes to them stealing the recent limelight as safe, smart, and versatile biomaterial in various fields such as cell culturing, − drug delivery, − and tissue engineering. − Recently, the potential of hydrogel as cell scaffold has been attracting much attention, owing to its ability to program cell behaviors such as adhesion, proliferation, and fate, by controlling its surface and bulk properties. − Of these properties, surface wettability has been known to be one of the parameters that critically affect such behaviors . Excellent results in increasing surface wettability through various methods such as introduction of charged groups within the hydrogel bulk, surface functionalization, and fabrication of hydrogel using hydrophilic polymers have been reported, and are now widely accepted standards of wettability modulation.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Bulk Physicochemical Properties and Surface Wettability of Hydrogels with Homogeneous Network Structure

et al. 2020

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Controlling hydrogel surface wettability is of great importance in the viewpoint of engineering biomaterials that are in contact with cells and tissues. However, studies reporting how the hydrogel bulk properties would affect the surface is scarce, and thus it has been difficult to fabricate hydrogels with the desired properties. Also, there has been no effective method to elucidate this, due to the inhomogeneity introduced in the network structure of conventional hydrogels. Here we report our approach in elucidating the relationship between hydrogel physicochemical parameters and surface wettability by using Tetra-PEG gels, which are known to have homogeneous network structure. Specifically, the polymer volume fraction (φ) and the molecular weight (M W ) between the cross-links were controlled. The number of anions, cations, and ionic pairs introduced within the hydrogel, were also individually controlled. The surface wettability of the resulting hydrogels was then evaluated. Results showed that surface wettability is largely dependent on the concentration of charged groups that are introduced in the hydrogel bulk, especially those that are not paired and ionically stabilized. Our findings strongly support the fact that with conventional hydrogels, the correlation between surface wettability and its physicochemical properties had not been evaluated appropriately, and thus our insights will contribute significantly to accumulating further knowledge on controlling hydrogel surface wettability.

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Section: Introductionmentioning

confidence: 99%

Relationship between Bulk Physicochemical Properties and Surface Wettability of Hydrogels with Homogeneous Network Structure

et al. 2020

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“…[ 126,153 ] In addition to the double‐response NHs list above, there are triple response NHs either, under the in‐depth research of scientists, the novel NHs with excellent pH, thermo, and magnetic responsive were fabricated. [ 134,153,167 ] Li et al. proposed a modular strategy for the synthesis of cationic NHS with tunable responsiveness, versatility, and biodegradability.…”

Section: The Function Of Injectable Nanocomposite Hydrogel and Its Application In Cancer Treatmentmentioning

confidence: 99%

Injectable Nanocomposite Hydrogels for Cancer Therapy

Zong

Guo

et al. 2021

Macromolecular Bioscience

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Hydrogel is a kind of 3D polymer network with strong swelling ability in water and appropriate mechanical and biological properties, which make it feasible to maintain bioactive substances and has promising applications in the fields of biomaterials, soft machines, and artificial tissues. Unfortunately, traditional hydrogels prepared by chemical crosslinking have poor mechanical properties and limited functions, which limit their further application. In recent years, with the continuous development of nanoparticle research, more and more studies have combined nanoparticles with hydrogels to make up for the shortcomings of traditional hydrogels. In this article, the types and functions of hydrogels and nanomaterials are introduced first, as well as the functions and applications of injectable nanocomposite hydrogels (INHs), then the latest progress of INHs for cancer treatment is reviewed, some existing problems are summarized, and the application prospect of NHs is prospected.

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“…The result showed that DOX release could be sustained for up to 12.5 days from these nanocomposite hydrogels, significantly longer than that achievable using the constituent hydrogel or nanogel alone (<1 day). Bardajee et al [65] have prepared poly [(Nisopropylacrylamide)-co-(2-dimethylamino ethyl methacrylate) nanogel by copolymerization processes and then added it into the solution of poly (2dimethylamino ethyl methacrylate)] grafted onto salep. Through dropwise addition of mixed aqueous solution of iron salts into the prepared polymeric solution, a novel hydrogel nanocomposite with pH, thermo, and magnetic responsive was fabricated.…”

Section: Microgelsmentioning

confidence: 99%

A Review on pH and Temperature Responsive Gels in Drug Delivery

2020

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Anticancer drugs play important roles in cancer treatment. However, these drugs have many disadvantages such as poor solubility, high toxicity, and serious side effects like hair loss, nausea and vomiting, anemia etc. To overcome these drawbacks, many attempts have been made to develop novel controlled drug delivery systems. They can encapsulate the drug and release it to the cancer site without leaking into other sites. The employment of multi-responsive hydrogels as a drug delivery system have some advantages over other drug delivery systems due to their ease of preparation, high efficiency, high-water content, tunable physical, and biological properties. The most advantages of these hydrogels is the volume phase transitions in their crosslinked three-dimensional networks as exposure to external stimuli such as temperature, pH, pressure, electric field, magnetic field and light. There has been research on other drug delivery systems which can respond to changes in pH and temperature for targeted drug release. Among those, gels have been studied mostly for their dual responsiveness. This provides an update on progress of gel based dual pH and temperature responsive drug delivery systems. Various systems under these categories for targeted and controlled delivery of different classes of drugs such as ant diabetic and antibiotic drugs with special emphasis on anticancer drugs are discussed in this review. Abstract: Biography:Ghasem Rezanejade Bardajee: He Received his Ph.D. degree in Chemistry from Sharif University of Technology. He is currently a professor at the faculty of chemistry of the Payame Noor University (Iran). His research encompasses the sensitive nanocomposite hydrogels, green chemistry, drug delivery, quantum dots, and solar cells.

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Embedded of Nanogel into Multi-responsive Hydrogel Nanocomposite for Anticancer Drug Delivery

Cited by 14 publications

References 33 publications

Relationship between Bulk Physicochemical Properties and Surface Wettability of Hydrogels with Homogeneous Network Structure

Relationship between Bulk Physicochemical Properties and Surface Wettability of Hydrogels with Homogeneous Network Structure

Injectable Nanocomposite Hydrogels for Cancer Therapy

A Review on pH and Temperature Responsive Gels in Drug Delivery

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