A Review on pH and Temperature Responsive Gels in Drug Delivery

Abstract

Anticancer drugs play important roles in cancer treatment. However, these drugs have many disadvantages such as poor solubility, high toxicity, and serious side effects like hair loss, nausea and vomiting, anemia etc. To overcome these drawbacks, many attempts have been made to develop novel controlled drug delivery systems. They can encapsulate the drug and release it to the cancer site without leaking into other sites. The employment of multi-responsive hydrogels as a drug delivery system have some advantages over other drug delivery systems due to their ease of preparation, high efficiency, high-water content, tunable physical, and biological properties. The most advantages of these hydrogels is the volume phase transitions in their crosslinked three-dimensional networks as exposure to external stimuli such as temperature, pH, pressure, electric field, magnetic field and light. There has been research on other drug delivery systems which can respond to changes in pH and temperature for targeted drug release. Among those, gels have been studied mostly for their dual responsiveness. This provides an update on progress of gel based dual pH and temperature responsive drug delivery systems. Various systems under these categories for targeted and controlled delivery of different classes of drugs such as ant diabetic and antibiotic drugs with special emphasis on anticancer drugs are discussed in this review. Abstract: Biography:Ghasem Rezanejade Bardajee: He Received his Ph.D. degree in Chemistry from Sharif University of Technology. He is currently a professor at the faculty of chemistry of the Payame Noor University (Iran). His research encompasses the sensitive nanocomposite hydrogels, green chemistry, drug delivery, quantum dots, and solar cells.

Application of Redox-Responsive Hydrogels Based on 2,2,6,6-Tetramethyl-1-Piperidinyloxy Methacrylate and Oligo(Ethyleneglycol) Methacrylate in Controlled Release and Catalysis

“…In the present contribution, we focus on stimuli-responsive chemical hydrogels. Typical stimuli include variations in temperature [11], pH [11], applied stress [12], magnetic and electromagnetic field [13], ionic strength [14], light [15] and the presence of bioactive species [16]. Redox-responsive gels have been scarcely reported.…”