Past, present and future of biomedical applications of dextran-based hydrogels: A review

Luanda, Amos; Vishalakshi, B.

doi:10.1016/j.ijbiomac.2022.12.129

Cited by 25 publications

(13 citation statements)

References 168 publications

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“…315316,317 Due to its unique physical and chemical properties, dextran has a variety of biomedical applications, such as plasma volume expander, drug delivery, blood sugar stabilizer, diagnostic imaging, and tissue regeneration. 318,319 Dex-based biomaterials inks has shown potential promise due to its biocompatibility, rheological properties, biodegradability, and hydrophilicity. 320,321 In a core−shell bioprinting strategy, peptide-functionalized modified dextran (dextran aldehyde) and succinylated chitosan used as the HUVECs-laden core component provide temporal structural support of surrounding hBMSCs-laden GelMA (13%) shell for wound healing applications.…”

Section: Ma Et Al Synthesized N-(2-aminoethyl)-4-(4-(hydroxymethyl)-mentioning

confidence: 99%

“…A thickening and stabilizing agent, dextran (Dex) is a water-soluble complex branched naturally occurring polysaccharide composed of d -glucose molecules linked together in α-(1 → 6) glycosidic bonds , Due to its unique physical and chemical properties, dextran has a variety of biomedical applications, such as plasma volume expander, drug delivery, blood sugar stabilizer, diagnostic imaging, and tissue regeneration. , Dex-based biomaterials inks has shown potential promise due to its biocompatibility, rheological properties, biodegradability, and hydrophilicity. , In a core–shell bioprinting strategy, peptide-functionalized modified dextran (dextran aldehyde) and succinylated chitosan used as the HUVECs-laden core component provide temporal structural support of surrounding hBMSCs-laden GelMA (13%) shell for wound healing applications . Moreover, HUVECs-delivered core component induced microvuscularization by forming a tubelike structure.…”

Section: Modulating Scaffold Properties Through Gelma Ink Modificationsmentioning

confidence: 99%

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Gelatin Methacryloyl (GelMA)-Based Biomaterial Inks: Process Science for 3D/4D Printing and Current Status

Das,

Jegadeesan,

Basu

2024

Biomacromolecules

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Tissue engineering for injured tissue replacement and regeneration has been a subject of investigation over the last 30 years, and there has been considerable interest in using additive manufacturing to achieve these goals. Despite such efforts, many key questions remain unanswered, particularly in the area of biomaterial selection for these applications as well as quantitative understanding of the process science. The strategic utilization of biological macromolecules provides a versatile approach to meet diverse requirements in 3D printing, such as printability, buildability, and biocompatibility. These molecules play a pivotal role in both physical and chemical cross-linking processes throughout the biofabrication, contributing significantly to the overall success of the 3D printing process. Among the several bioprintable materials, gelatin methacryloyl (GelMA) has been widely utilized for diverse tissue engineering applications, with some degree of success. In this context, this review will discuss the key bioengineering approaches to identify the gelation and cross-linking strategies that are appropriate to control the rheology, printability, and buildability of biomaterial inks. This review will focus on the GelMA as the structural (scaffold) biomaterial for different tissues and as a potential carrier vehicle for the transport of living cells as well as their maintenance and viability in the physiological system. Recognizing the importance of printability toward shape fidelity and biophysical properties, a major focus in this review has been to discuss the qualitative and quantitative impact of the key factors, including microrheological, viscoelastic, gelation, shear thinning properties of biomaterial inks, and printing parameters, in particular, reference to 3D extrusion printing of GelMA-based biomaterial inks. Specifically, we emphasize the different possibilities to regulate mechanical, swelling, biodegradation, and cellular functionalities of GelMA-based bio(material) inks, by hybridization techniques, including different synthetic and natural biopolymers, inorganic nanofillers, and microcarriers. At the close, the potential possibility of the integration of experimental data sets and artificial intelligence/machine learning approaches is emphasized to predict the printability, shape fidelity, or biophysical properties of GelMA bio(material) inks for clinically relevant tissues.

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Section: Ma Et Al Synthesized N-(2-aminoethyl)-4-(4-(hydroxymethyl)-mentioning

confidence: 99%

Section: Modulating Scaffold Properties Through Gelma Ink Modificationsmentioning

confidence: 99%

Gelatin Methacryloyl (GelMA)-Based Biomaterial Inks: Process Science for 3D/4D Printing and Current Status

Das,

Jegadeesan,

Basu

2024

Biomacromolecules

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“…Polysaccharides are composed of regularly repeating units connected by glycosidic linkages. − The potential for developing biomaterials with adjustable properties exists since polysaccharides contain a large number of organic functional groups. Recently, various natural microbial polysaccharides, such as dextran, gellan gum, and xanthan gum, have been investigated as the basic ingredient in hydrogels for biomedical applications. − …”

Section: Introductionmentioning

confidence: 99%

Hydrogel Based on Riclin Cross-Linked with Polyethylene Glycol Diglycidyl Ether as a Soft Filler for Tissue Engineering

Lu,

Wang,

Kong

et al. 2024

Biomacromolecules

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Hydrogels composed of natural polysaccharides have been widely used as filling materials, with a growing interest in medical cosmetology and skin care. However, conventional commercial dermal fillers still have limitations, particularly in terms of mechanical performance and durability in vivo. In this study, a novel injectable and implantable hydrogel with adjustable characteristics was prepared from succinoglycan riclin by introducing PEG diglycidyl ether as a cross-linker. FTIR spectra confirmed the cross-linking reaction. The riclin hydrogels exhibited shear-thinning behavior, excellent mechanical properties, and cytocompatibility through in vitro experiments. Furthermore, when compared with subcutaneous injection of a commercial hyaluronic acid hydrogel, the riclin hydrogels showed enhanced persistence and biocompatibility in Balb/c mice after 16 weeks. These results demonstrate the great potential of the riclin-based hydrogel as an alternative to conventional commercial soft tissue fillers.

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“…Traditional hydrogels are made from natural materials including proteins, polysaccharides, and synthetic polymers. 1 Chitosan, 2 hyaluronic acid (HA), 3 cellulose, 4 alginate, 5,6 dextran, 7 etc. are examples of polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

The engineering and application of extracellular matrix hydrogels: a review

Zhang

2023

Biomater. Sci.

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Past, present and future of biomedical applications of dextran-based hydrogels: A review

Cited by 25 publications

References 168 publications

Gelatin Methacryloyl (GelMA)-Based Biomaterial Inks: Process Science for 3D/4D Printing and Current Status

Gelatin Methacryloyl (GelMA)-Based Biomaterial Inks: Process Science for 3D/4D Printing and Current Status

Hydrogel Based on Riclin Cross-Linked with Polyethylene Glycol Diglycidyl Ether as a Soft Filler for Tissue Engineering

The engineering and application of extracellular matrix hydrogels: a review

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