ISBN: 0-7695-2580This paper describes our experience in using the POSIX API standard for MPSoC applications prototyping on a reconfigurable multiprocessor ARM architecture. Applications running on this platform use a Symmetric Multiprocessor (SMP) POSIX compliant kernel named MUTEK. This work allows us to investigate and understand the complexities of the Hardware/Software interface design process. We propose a new generic MPSoC prototyping flow based on the POSIX standard, which allows fast prototyping of POSIX threads based applications