Embden–Meyerhof–Parnas and Entner–Doudoroff pathways in Thermoproteus tenax: metabolic parallelism or specific adaptation?

Abstract

Genome data as well as biochemical studies have indicated that--as a peculiarity within hyperthermophilic Archaea--Thermoproteus tenax uses three different pathways for glucose metabolism, a variant of the reversible EMP (Embden-Meyerhof-Parnas) pathway and two different modifications of the ED (Entner-Doudoroff) pathway, a non-phosphorylative and a semi-phosphorylative version. An overview of the three different pathways is presented and the physiological function of the variants is discussed.

Role of Central Metabolism in the Osmoadaptation of the Halophilic Bacterium Chromohalobacter salexigens

“…In hyperthermophilic archaea, it has been proposed that the presence of nonphosphorylative and semi-phosphorylative variants of the ED pathway may play an important role for thermoadaptation, allowing cells to avoid the production of heat-labile intermediaries (54). Although it is not clear whether this pathway confers any advantage for adaptation to high salinity, considerations of the overall balance of the pathway may shed light on the reason for its preferential utilization.…”

Manche mögen's heiß — und sauer! Zuckerabbau in Sulfolobus solfataricus

“…Außerdem wird durch Nutzen des npEDZweigs zusätzlich die Bildung von GAP mit einer Halbwertszeit von 14 Minuten bei 60°C vermieden (Abb. 3B, [10]). …”

SulfoSYS (Sulfolobus Systems Biology): towards a silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation

“…The physiological role of the two ED branches, as well as their regulation, is still unclear [21,30]. GAPN is the only enzyme of the pathway known so far to be subject to allosteric control ( Figure 2).…”