Elution kinetics, antimicrobial activity, and mechanical properties of 11 different antibiotic loaded acrylic bone cement

Gálvez-López, R.; Peña-Monje, Alejandro; Antelo-Lorenzo, Ramón; Guardia-Olmedo, Juan; Moliz, Juan N.; Hernández-Quero, José; Parra-Ruiz, Jorge

doi:10.1016/j.diagmicrobio.2013.09.014

Cited by 80 publications

(64 citation statements)

References 25 publications

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“…Both tests with eluates as well as with bone cement specimens revealed that lowest concentrated daptomycin (0.5 g/40 g powder) was not as active as the highest tested concentration of the antibiotic (1.5 g/40 g powder) against MRSA, S. epidermidis, and E. faecium . This may be confirmative to a recent reports about release profiles of PMMA bone-cement showing a continuous longer release [25–27] and antimicrobial activity of daptomycin when loaded with higher concentrations [26, 27]. If the cement was loaded with daptomycin and gentamicin, release profiles showed a prolonged antimicrobial activity in comparison with the single antibiotics.…”

Section: Discussionsupporting

confidence: 89%

Activity of Fosfomycin- and Daptomycin-Containing Bone Cement on Selected Bacterial Species Being Associated with Orthopedic Infections

Eick

Hofpeter

Sculean

et al. 2017

BioMed Research International

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The purpose of this study was to determine activity of fosfomycin/gentamicin and daptomycin/gentamicin-containing PMMA bone-cement against Staphylococcus aureus (MRSA, MSSA), Staphylococcus epidermidis, Enterococcus faecium (VRE), and E. coli (ESBL; only fosfomycin). Test specimens of the bone cement were formed and bacteria in two concentrations were added one time or repeatedly up to 96 h. All fosfomycin-containing cement killed ultimately all MSSA, Staphylococcus epidermidis, and E. coli within 24 h; growth of MRSA was suppressed up to 48 h. Activity of daptomycin-containing cement depended on the concentration; the highest concentrated bone cement used (1.5 g daptomycin/40 g of powder) was active against all one-time added bacteria. When bacteria were added repeatedly to fosfomycin-containing cement, growth was suppressed up to 96 h and that of MRSA and VRE only up to 24 h. The highest concentration of daptomycin suppressed the growth of repeated added bacteria up to 48 h (VRE) until 96 h (MSSA, MRSA). In conclusion, PMMA bone cement with 1.5 g of daptomycin and 0.5 g of gentamicin may be an alternative in treatment of periprosthetic infections caused by Gram-positive bacteria.

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Section: Discussionsupporting

confidence: 89%

Activity of Fosfomycin- and Daptomycin-Containing Bone Cement on Selected Bacterial Species Being Associated with Orthopedic Infections

Eick

Hofpeter

Sculean

et al. 2017

BioMed Research International

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“…When analyzed in terms of antimicrobial activity, higher drug concentrations achieved with Palacos fail to elicit enhanced efficacy. [21,[29][30][31][32][33][34] In contrast to the aforementioned studies, our results yielded similar drug concentrations with Palacos, CMW 3, and Simplex P. Despite the similar antibiotics concentrations, samples from Simplex P showed lower antibacterial activity. Decreased antibacterial activity from similar drug concentrations may be due the effect of different levels of heat generated during exothermic reaction of the drug molecule, or due to imprecise semi-quantitative methods for analyzing drug activity.…”

Section: Discussioncontrasting

confidence: 56%

Antibiotic release and antibacterial efficacy in cement spacers and cement beads impregnated with different techniques: In vitro study

Atıcı

Şahin²,

Çavun³

et al. 2018

Eklem Hastalik Cerrahisi

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“…However, with the subsiding of precaution in the late phase, for example the decrease of antibiotic concentration from antibiotic-loaded cement (52,53), S. aureus may rapidly cause infections.…”

Section: Summary and Interpretation Of Main Resultsmentioning

confidence: 99%

Distribution characteristics of Staphylococcus spp. in different phases of periprosthetic joint infection: A review

Guo

Wang

You

et al. 2017

Experimental and Therapeutic Medicine

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Periprosthetic joint infection (PJI) is a devastating condition and Staphylococcus spp. are the predominant pathogens responsible, particularly coagulase-negative staphylococci (CoNS) and Staphylococcus aureus. The aim of the present systematic review was to evaluate the distribution characteristics of specific Staphylococcus spp. in different PJI phases, reveal the effect of pathogens' feature on their distribution and suggest recommendations for antibiotic treatment of Staphylococcal PJI. The present systematic review was performed using PubMed and EMBASE databases with the aim to identify existing literature that presented the spectrum of Staphylococcus spp. that occur in PJI. Once inclusion and exclusion criteria were applied, 20 cohort studies involving 3,344 cases in 3,199 patients were included. The predominant pathogen involved in PJI was indicated to be CoNS (31.2%), followed by S. aureus (28.8%). This trend was more apparent in hip replacement procedures. In addition, almost equal proportions of CoNS and S. aureus (28.6 and 30.0%, respectively) were indicated in the delayed phase. CoNS (36.6%) were the predominant identified organism in the early phase, whereas S. aureus (38.3%) occurred primarily in the late phase. In PJI caused by S. aureus, the number of cases of methicillin-sensitive Staphylococcus aureus (MSSA) was ~2.5-fold greater than that of methicillin-resistant Staphylococcus aureus (MRSA). MRSA occurred predominantly in the early phase, whereas MSSA was largely observed in the delayed and late phases. With regards to antibiotic treatment, the feature of various pathogens and the phases of PJI were the primary considerations. The present review provides useful information for clinical practice and scientific research of PJI.

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Elution kinetics, antimicrobial activity, and mechanical properties of 11 different antibiotic loaded acrylic bone cement

Cited by 80 publications

References 25 publications

Activity of Fosfomycin- and Daptomycin-Containing Bone Cement on Selected Bacterial Species Being Associated with Orthopedic Infections

Activity of Fosfomycin- and Daptomycin-Containing Bone Cement on Selected Bacterial Species Being Associated with Orthopedic Infections

Antibiotic release and antibacterial efficacy in cement spacers and cement beads impregnated with different techniques: In vitro study

Distribution characteristics of Staphylococcus spp. in different phases of periprosthetic joint infection: A review

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