Antibiotic release and antibacterial efficacy in cement spacers and cement beads impregnated with different techniques: In vitro study

Atıcı, Teoman; Şahin, Namık; Çavun, Sinan; Özakın, Cüneyt; Kaleli, Tufan

doi:10.5606/ehc.2018.59021

Cited by 10 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Existing bone cements have several drawbacks, like poor antibacterial efficacy and antibiotic elution from the polymethylmethacrylate matrix (Atıcı et al., 2018 ). Many antibiotic delivery systems based on nanotechnology, comprising clay nanotubes, polymeric NPs, hydroxyapatite nanorods, liposomes, and carbon nanotubes, have been investigated to increase the medication release profile of polymethylmethacrylate bone cement (Al Thaher et al., 2017 ; Aşık et al., 2019 ; Çağlar et al., 2020 ).…”

Section: Nano-based Dds Application In Orthopedicsmentioning

confidence: 99%

An update on the advances in the field of nanostructured drug delivery systems for a variety of orthopedic applications

Liang,

Zhou,

Jin

et al. 2023

Drug Delivery

View full text Add to dashboard Cite

Nanotechnology has made significant progress in various fields, including medicine, in recent times. The application of nanotechnology in drug delivery has sparked a lot of research interest, especially due to its potential to revolutionize the field. Researchers have been working on developing nanomaterials with distinctive characteristics that can be utilized in the improvement of drug delivery systems (DDS) for the local, targeted, and sustained release of drugs. This approach has shown great potential in managing diseases more effectively with reduced toxicity. In the medical field of orthopedics, the use of nanotechnology is also being explored, and there is extensive research being conducted to determine its potential benefits in treatment, diagnostics, and research. Specifically, nanophase drug delivery is a promising technique that has demonstrated the capability of delivering medications on a nanoscale for various orthopedic applications. In this article, we will explore current advancements in the area of nanostructured DDS for orthopedic use.

show abstract

Section: Nano-based Dds Application In Orthopedicsmentioning

confidence: 99%

An update on the advances in the field of nanostructured drug delivery systems for a variety of orthopedic applications

Liang,

Zhou,

Jin

et al. 2023

Drug Delivery

View full text Add to dashboard Cite

show abstract

“…The bone cements which have been currently used have several limitations including antibacterial performance and elution of antibiotics from polymethylmethacrylate matrix. [61] A variety of nanotechnology-based antibiotic delivery systems have been explored to improve the drug release profile from polymethylmethacrylate bone cement including polymeric nanoparticles, carbon nanotubes, liposomes, clay nanotubes, and hydroxyapatite nanorods. [62][63][64]…”

Section: Orthopedic Infectionsmentioning

confidence: 99%

Nanotechnology-based drug delivery systems in orthopedics

Güven

2021

Jt Dis Relat Surg

View full text Add to dashboard Cite

Nanotechnology is a multidisciplinary branch of science which involves the manipulation and control of matter at the nanometer scale to produce new structures, materials, and devices. The concept of nanotechnology was first introduced by Richard P. Feynman [1] in 1959. Since then, nanotechnology has become a research area which promises advancements in many aspects of human life, including electronics, agriculture, transportation, food industry, communication, energy, biological sciences, and medicine. Nanomedicine, the application of nanotechnology in the field of medicine, has the potential to make a great impact on human health and has already impacted and reshaped many aspects of clinical practice and research. Nanotechnology-based materials with unique physical, chemical, and biological characteristics offer a variety of new approaches for clinical practices ranging from prevention to treatment and diagnosis of many diseases and conditions. [2][3][4][5] Among all the applications of nanotechnology in medicine, nano-based drugIn recent years, nanotechnology has led to significant scientific and technological advances in diverse fields, specifically within the field of medicine. Owing to the revolutionary implications in drug delivery, nanotechnology-based drug delivery systems have gained an increasing research interest in the current medical field. A variety of nanomaterials with unique physical, chemical and biological properties have been engineered to develop new drug delivery systems for the local, sustained and targeted delivery of drugs with improved therapeutic efficiency and less or no toxicity, representing a very promising approach for the effective management of diseases. The utility of nanotechnology, particularly in the field of orthopedics, is a topic of extensive research. Nanotechnology has a great potential to revolutionize treatment, diagnostics, and research in the field of orthopedics. Nanophase drug delivery has shown great promise in their ability to deliver drugs at nanoscale for a variety of orthopedic applications. In this review, we discuss recent advances in the field of nanostructured drug delivery systems for orthopedic applications.

show abstract

“…[ 23 ] The exact mechanism of antibiotic elution from ALBC remains uncertain. [ 24 ] Based on in vitro elution measurements, there is a hypothesis describing it as a bi-phasic process. [ 15 , 25 , 26 ] Antibiotics are usually premixed with the cement powder.…”

Section: Antibiotic Elution Kinetics Of Albcmentioning

confidence: 99%

Progress of antibiotic-loaded bone cement in joint arthroplasty

Peng

Feng

et al. 2020

Chinese Medical Journal

View full text Add to dashboard Cite

Bone cement, consisting of polymethyl methacrylate, is a bioinert material used for prothesis fixation in joint arthroplasty. To treat orthopedic infections, such as periprosthetic joint infection, antibiotic-loaded bone cement (ALBC) was introduced into clinical practice. Recent studies have revealed the limitations of the antibacterial effect of ALBC. Moreover, with the increase in high infection risk patients and highly resistant microbes, more researches and modification of ALBC are required. This paper reviewed latest findings about ALBC for most popular and destructive pathogens, summarized the influence of antibiotic kind, drug dosage, application method, and environment towards characteristic of ALBC. Subsequently, new cement additives and clinical applications of ALBC in joint arthroplasty were also discussed.

show abstract

Antibiotic release and antibacterial efficacy in cement spacers and cement beads impregnated with different techniques: In vitro study

Cited by 10 publications

References 30 publications

An update on the advances in the field of nanostructured drug delivery systems for a variety of orthopedic applications

An update on the advances in the field of nanostructured drug delivery systems for a variety of orthopedic applications

Nanotechnology-based drug delivery systems in orthopedics

Progress of antibiotic-loaded bone cement in joint arthroplasty

Contact Info

Product

Resources

About