Elucidation on enhanced application of synthesised kojic acid immobilised magnetic and chitosan tri‐polyphosphate nanoparticles as antibacterial agents

Abstract

Kojic acid (KA) is a secondary metabolite which is secreted by several aspergillus species. It is a multi-functional skeleton from which many derivatives can be synthesised and applied in various areas of biotechnology. KA grafting on synthesised magnetic nanoparticles (MNPs) and chitosan tri-polyphosphate (chitosan-TPP) nanoparticles was successfully done and characterised by Fourier transformation infrared spectroscopy. It was observed that amino propyl triethoxy silane-coated MNPs and chitosan-TPP nanoparticles enhanced the antibacterial activity of KA against both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa). The organic constitution and significant antibacterial activity of KA-chitosan-TPP nanoparticles can be applicable in the field of medical biotechnology.

Kojic acid and tea polyphenols inactivate Escherichia coli O157:H7 in vitro and on salmon fillets by inflicting damage on cell membrane and binding to genomic DNA

“…According to previous reports, KA has reverse antibacterial activities different from most natural antibacterial agents, that is, KA is more active against gram‐negative bacteria than gram‐positive ones (Chaudhary et al ., 2015; Wu et al ., 2019). Besides, TP is generally considered to be a broad‐spectrum antibacterial agent, but many studies have indicated that TP performed better in inhibiting gram‐positive bacteria than gram‐negative bacteria (Gordon & Wareham, 2010; He et al ., 2016).…”

Evaluation of antibacterial and anti-biofilm properties of kojic acid against five food-related bacteria and related subcellular mechanisms of bacterial inactivation

“…Previous studies related to antimicrobial activity had shown that KA was more active against Gram-negative bacteria than against Gram-positive ones (Bentley, 2006). This reverse effect with KA is, therefore, of special interest and many efforts have been made to use KA as a multi-functional skeleton for producing many derivatives to enhance the biological activity of KA, especially its antimicrobial property against not only Gram-negative but also Gram-positive bacteria (Chaudhary et al., 2015; Liu et al., 2015). However, the information related to antibacterial activities of KA and the mechanism of bacterial inactivation caused by KA from the biological perspective of the bacteria has not been well defined.…”