Elucidating the influence of electrostatic force on the re-arrangement of H-bonds of protein polymers in the presence of salts

Basu, Tithi; Das, Sougat; Majumdar, Saptarshi

doi:10.1039/d3sm01440a

Soft Matter

2024

DOI: 10.1039/d3sm01440a

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Elucidating the influence of electrostatic force on the re-arrangement of H-bonds of protein polymers in the presence of salts

Tithi Basu,

Sougat Das,

Saptarshi Majumdar

Abstract: Polyampholytes/proteins have an intriguing network of hydrogen bonds (H-bonds), especially their secondary structure which plays a crucial role in determining the conformational stability of the polymer. The changes in protein...

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An Experimentally Derived Prediction Model for Diffusion and Electrostatically Controlled Physical Interactions of Polyampholytes and Salts

Das,

Majumdar

2024

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The interactions of salts with polyampholytes are well established using the Hofmeister series. However, the effect of these salts on the diffusivities of polyampholytes is unknown. This article discusses these electrostatically driven physical interactions using two developed prediction models. Sodium and Potassium salts are considered with 3 chaotropic anions and 2 kosmotropic anions. A dimensionless parameter has been developed to predict the trend for these salt interactions. Another model has been developed to predict these interactions for different salt mixtures. The effect of these salts and the mixtures on the second virial coefficient is also studied, and statistical clustering using the k‐means method has been defined, which can provide insight towards the changes in the solution properties of polyampholytes with these salt mixtures. At lower pH, the salt first screens the repulsions in the polyampholytes followed by a re‐expansion phenomenon.

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An Experimentally Derived Prediction Model for Diffusion and Electrostatically Controlled Physical Interactions of Polyampholytes and Salts

Das,

Majumdar

2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

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Elucidating the influence of electrostatic force on the re-arrangement of H-bonds of protein polymers in the presence of salts

Abstract: Polyampholytes/proteins have an intriguing network of hydrogen bonds (H-bonds), especially their secondary structure which plays a crucial role in determining the conformational stability of the polymer. The changes in protein...

Cited by 1 publication

References 58 publications

An Experimentally Derived Prediction Model for Diffusion and Electrostatically Controlled Physical Interactions of Polyampholytes and Salts

An Experimentally Derived Prediction Model for Diffusion and Electrostatically Controlled Physical Interactions of Polyampholytes and Salts

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