Elongated nanoporous Au networks improve somatic cell direct conversion into induced dopaminergic neurons for Parkinson's disease therapy

Lee, Sung‐Woo; Shim, Hyun Soo; Park, Hyeok Ju; Chang, Yu‐Jung; Han, Young-eun; Oh, Soo‐Jin; Lee, Wonwoong; Im, Hyeonjoo; Seol, YunHee; Ryu, Hoon; Kang, Hoon; Lee, Yong Kyu; Park, Sungho; Yoo, Jang-Yong

doi:10.1016/j.actbio.2022.07.058

Cited by 4 publications

(15 citation statements)

References 57 publications

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“…The table below shows the various type of DLR accelerator: small molecules, miRNA and biocompatible materials: nanoparticles. Especially, Yoo et al [14] and his group investigated the specific method to boost up the dopaminergic neuronal DLR from astrocyte. They have revealed that gold nanoporous rod accelerates astrocyte into dopaminergic neuron in vivo DLR by controlling the ROS level and optimize the cell stress and its function.…”

Section: Neuronal Dlr Acceleratormentioning

confidence: 99%

“…Many researchers have been trying to investigate the method to accelerate the reprogramming efficiency from decade ago. Recently, couple research groups have revealed that specifically modified nanoparticles: gold nanoporous rod can boost up the reprogramming efficiency by activating cell master regulators: Gsta4, Mt3, Sod1, Cox6b2, Sirt3, etc [14]. Incorporation of these master regulators into neuronal reprogramming may open a new era for neurological disease such as PD, AD and SCI (Figure 2).…”

Section: What Is New and Conclusion?mentioning

confidence: 99%

“…Neuronal DLR enables direct astrocytes or fibroblasts to get transformed into functional neurons (motor/sensory neurons, GABAergic neurons, dopaminergic neurons, etc) using a set of lineage-specific transcription factors [9,[11][12][13]. More specifically direct converted induced Motor Neuronal (iMN) properties can be investigated using electrophysiological analysis [14].…”

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confidence: 99%

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Novel Gene Therapies Technology for Spinal Cord Injury (SCI) Therapy: Efficient Direct Lineage Reprogramming

Kim¹,

Shim²,

Chang³

et al. 2022

JCPT

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What is known and objectives: Spinal Cord Injury (SCI) is defined for the last few decades as patients getting wheelchair bound and under medication for a lifetime [1]. Medical battery for SCI is very limited which often results in heightened frustration for the caregivers who land up with no solid solution to the condition. However, in recent times due to the huge volume of research, neuroscience has progressed massively through GT offering better insight and high hopes of neural regeneration and functional rehabilitation [2]. As GT technology becomes more popular as an emerging therapeutic method, many studies using a manufactured virus (AAV, retro, adeno, lenti) are opening up promising research avenues [3-5]. In this review, we dealt with Direct Lineage Reprogramming (DLR) technology for a novel GT method for SCI patients.

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Section: Neuronal Dlr Acceleratormentioning

confidence: 99%

Section: What Is New and Conclusion?mentioning

confidence: 99%

mentioning

confidence: 99%

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Novel Gene Therapies Technology for Spinal Cord Injury (SCI) Therapy: Efficient Direct Lineage Reprogramming

Kim¹,

Shim²,

Chang³

et al. 2022

JCPT

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“…The researchers observed that AuNpRs functioned as ROS scavengers in DLR, thus, lowering internal cellular conversion stress. Their discovery demonstrated that the use of AuNpRs enhanced the efficiency of DLR-induced dopaminergic (iDA) neurons originating from brain astrocytes, thereby, ameliorating the Parkinsonian phenotype in animal models [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…Neurological disorders are one of the major interests in the field of gene therapy, with many researchers suggesting the possibility of treating neurological diseases, such as PD and SCI, using DLR technology. The use of master regulators that positively control cellular stress or activate the neuronal actuator (related genes) by opening the related chromatin can serve as a novel therapeutic approach for treating neurological diseases using DLR technology [ 29 , 30 ]. Another way to accelerate DLR is to apply modified nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Gene Therapy Using Efficient Direct Lineage Reprogramming Technology for Neurological Diseases

Chang¹,

Lee

Kim

et al. 2023

Nanomaterials

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Gene therapy is an innovative approach in the field of regenerative medicine. This therapy entails the transfer of genetic material into a patient’s cells to treat diseases. In particular, gene therapy for neurological diseases has recently achieved significant progress, with numerous studies investigating the use of adeno-associated viruses for the targeted delivery of therapeutic genetic fragments. This approach has potential applications for treating incurable diseases, including paralysis and motor impairment caused by spinal cord injury and Parkinson’s disease, and it is characterized by dopaminergic neuron degeneration. Recently, several studies have explored the potential of direct lineage reprogramming (DLR) for treating incurable diseases, and highlighted the advantages of DLR over conventional stem cell therapy. However, application of DLR technology in clinical practice is hindered by its low efficiency compared with cell therapy using stem cell differentiation. To overcome this limitation, researchers have explored various strategies such as the efficiency of DLR. In this study, we focused on innovative strategies, including the use of a nanoporous particle-based gene delivery system to improve the reprogramming efficiency of DLR-induced neurons. We believe that discussing these approaches can facilitate the development of more effective gene therapies for neurological disorders.

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Astrocyte-to-neuron reprogramming and crosstalk in the treatment of Parkinson's disease

Wang

Xia

Kou

et al. 2023

Neurobiology of Disease

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Elongated nanoporous Au networks improve somatic cell direct conversion into induced dopaminergic neurons for Parkinson's disease therapy

Cited by 4 publications

References 57 publications

Novel Gene Therapies Technology for Spinal Cord Injury (SCI) Therapy: Efficient Direct Lineage Reprogramming

Novel Gene Therapies Technology for Spinal Cord Injury (SCI) Therapy: Efficient Direct Lineage Reprogramming

Gene Therapy Using Efficient Direct Lineage Reprogramming Technology for Neurological Diseases

Astrocyte-to-neuron reprogramming and crosstalk in the treatment of Parkinson's disease

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