Astrocyte-to-neuron reprogramming and crosstalk in the treatment of Parkinson's disease

Wang, Yiming; Xia, Yun; Kou, Liang; Yin, Sijia; Chi, Xiaosa; Li, Jingwen; Sun, Yi‐Feng; Wu, Jiawei; Zhou, Qiulu; Zou, W.; Jin, Ze; Huang, Jinsha; Xiong, Nian; Wang, T.

doi:10.1016/j.nbd.2023.106224

Cited by 6 publications

(1 citation statement)

References 192 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, successful transplantation of iPSC-derived dopaminergic neurons in patients with PD has shown significant improvement in patients’ symptoms and quality of life, leading to potential therapeutic approaches and also for other neurodegenerative diseases such as AD, ALS, Huntington’s disease [ 238 , 239 ]. The autologous cell therapy approach of direct reprogramming of midbrain astrocytes to replace lost dopaminergic neurons in PD has shown a promising alternative therapy for PD [ 240 , 241 ]. The significance of the Gdap1 gene has been recognized for its link to rapid degeneration in iPSC-derived motor neurons due to an altered mitochondrial metabolism-induced redox-inflammatory axis [ 242 ].…”

Section: The Use Of Ipsc-derived Cells In Neuroinflammatory Disease P...mentioning

confidence: 99%

Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders

Cohen,

Mathew,

Dourvetakis

et al. 2024

Cells

View full text Add to dashboard Cite

Neuroinflammatory and neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis (ALS) are chronic major health disorders. The exact mechanism of the neuroimmune dysfunctions of these disease pathogeneses is currently not clearly understood. These disorders show dysregulated neuroimmune and inflammatory responses, including activation of neurons, glial cells, and neurovascular unit damage associated with excessive release of proinflammatory cytokines, chemokines, neurotoxic mediators, and infiltration of peripheral immune cells into the brain, as well as entry of inflammatory mediators through damaged neurovascular endothelial cells, blood–brain barrier and tight junction proteins. Activation of glial cells and immune cells leads to the release of many inflammatory and neurotoxic molecules that cause neuroinflammation and neurodegeneration. Gulf War Illness (GWI) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are chronic disorders that are also associated with neuroimmune dysfunctions. Currently, there are no effective disease-modifying therapeutic options available for these diseases. Human induced pluripotent stem cell (iPSC)-derived neurons, astrocytes, microglia, endothelial cells and pericytes are currently used for many disease models for drug discovery. This review highlights certain recent trends in neuroinflammatory responses and iPSC-derived brain cell applications in neuroinflammatory disorders.

show abstract