Ellagitannin Toxicity in the Free-Living Soil-Inhabiting Nematode, &lt;i&gt;Caenorhabditis elegans&lt;/i&gt;

智昭, 森; Mohamed, A.S.A.; 正資, 佐藤; 徹, 山崎

doi:10.1584/jpestics.25.405

Cited by 20 publications

(14 citation statements)

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“…This ability could explain the cuticular changes observed by scanning electron microscopy after contact with CT (Hoste et al, 2006). Previous studies have shown that massive lesions have been found in the digestive and reproductive tracts of worms after contact with ellagic tannins (Mori et al, 2000). The CT extracts from various forages have been shown to reduce the development of nematode eggs to L 3 infective larvae as well as the production of eggs (Molan et al, 1999).…”

Section: Fecal Egg Countsmentioning

confidence: 89%

Effects of pine bark supplementation on performance, rumen fermentation, and carcass characteristics of Kiko crossbred male goats1

Min

Solaiman

Gurung

et al. 2012

Journal of Animal Science

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Twenty-two Kiko crossbred male goats (Capra hircus; initial BW = 27.5 ± 1.04 kg) were used in a randomized complete block design to determine the effects of feeding pine bark (PB; Pinus taeda L.) on animal performance, rumen fermentation, blood parameters, fecal egg counts (FEC), and carcass characteristics in goats. Experimental treatments included the control diet [0% PB plus 30% wheat straw (WS)], 15% PB plus 15% WS, and 30% PB plus 0% WS (on as-fed basis), where PB replaced WS. Freshly air-dried PB and WS were finely (1.5 to 3.0 mm) ground and incorporated in the grain mixes. Experimental diets provided a total of 1.9, 16.3, and 32 g of condense tannins (CT)/kg DM in 0%, 15%, and 30% PB diets, respectively. The grain mixes were fed daily at 85% of the feed offered, with remaining 15% consisting of Bermuda grass hay (Cynodon dactylon). Animals were fed once a day at 0800 h, and feed offered and refused was monitored for an 83-d performance period. Rumen and blood samples were collected at d 0, 50, and 80 of the study. Carcass traits were assessed after slaughter at the end of performance period. There was no difference in initial BW, hay, and total NDF intake among treatments; however, final BW (P = 0.06), ADG (P < 0.01), grain mix intake (P < 0.001), total DMI (P < 0.001), and G:F (P < 0.04) increased linearly as the PB increased in the diets. Rumen ammonia N, acetate, isovalerate and acetate-to-propionate ratio were reduced linearly (P < 0.05). There was no difference in carcass traits except cold carcass weight (P = 0.06), which tended to increase linearly in goats fed 15% and 30% PB. Breast, sirloin, trim trait, liver, and hide weight increased (linear; P < 0.01) with addition of PB. Blood basophils, alanine transaminase, aspartate aminotransferase, albumin, Na, and Cl concentrations decreased (linear; P < 0.02 to 0.01) as PB supplementation increased. Supplementation of PB reduced (linear; P < 0.01) average FEC. Addition of PB in the diets improved performance, reduced FEC, and favorably modified rumen fermentation.

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Section: Fecal Egg Countsmentioning

confidence: 89%

Effects of pine bark supplementation on performance, rumen fermentation, and carcass characteristics of Kiko crossbred male goats1

Min

Solaiman

Gurung

et al. 2012

Journal of Animal Science

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“…Bristol (strain N2), a stock culture was incubated under standard conditions, and the dauer stage was induced by starvation, followed by incubation of the dauer populations on 3.5-cm NGM agar plates seeded with Escherichia coli strain OP50 at 20°C [10]. Three-animal sets were incubated on E. coli in 200-lL complete S medium containing one of the samples in 250-lL hemiellipsoidal wells at 20°C [3,11]. DMSO at concentrations up to 1% has no effect on the development of C. elegans [12].…”

Section: Generalmentioning

confidence: 99%

Potential anthelmintics: polyphenols from the tea plant Camellia sinensis L. are lethally toxic to Caenorhabditis elegans

et al. 2008

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A novel gallate of tannin, (-)-epigallocatechin-(2 beta-->O-->7',4 beta-->8')-epicatechin-3'-O-gallate (8), together with (-)-epicatechin-3-O-gallate (4), (-)-epigallocatechin (5), (-)-epigallocatechin-3-O-gallate (6), and (+)-gallocatechin-(4 alpha-->8')-epigallocatechin (7), were isolated from the tea plant Camellia sinensis (L.) O. Kuntze var. sinensis (cv., Yabukita). The structure of 8, including stereochemistry, was elucidated by spectroscopic methods and hydrolysis. The compounds, along with commercially available pyrogallol (1), (+)-catechin (2), and (-)-epicatechin (3), were examined for toxicity towards egg-bearing adults of Caenorhabditis elegans. The anthelmintic mebendazole (9) was used as a positive control. Neither 2 nor 3 were toxic but the other compounds were toxic in the descending order 8, 7 approximately 6, 9, 4, 5, 1. The LC(50) (96 h) values of 8 and 9 were evaluated as 49 and 334 micromol L(-1), respectively. These data show that many green tea polyphenols may be potential anthelmintics.

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“…[2][3][4][5][6][7] These tests are adopted as a bioassay system for ecological risk assessment and screening of drugs in pharmaceutics. Most studies have focused on the effects of metals or agricultural chemicals, but little is known about the relative toxic effects of other environmental chemicals on C. elegans.…”

Section: Introductionmentioning

confidence: 99%

Aquatic Acute Toxicity Testing Using the Nematode Caenorhabditis elegans.

Ura

Kai

Sakata

et al. 2002

JOURNAL OF HEALTH SCIENCE

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To evaluate the toxicity of environmental chemicals to invertebrates, a static bioassay was developed in the laboratory using the Caenorhabditis elegans (C. elegans). First, reproducibility of this aquatic acute toxicity test system was confirmed. In order to estimate chemical toxicities in C. elegans, worms were subsequently exposed to eleven different xenobiotics. Mortality after 24 hr was adopted as the endpoint of toxicity. We found that benzo[a]pyrene, nonylphenol, benzophenone, bisphenol A and cadmium chloride affected viability of C. elegans. These data suggest that C. elegans is a suitable toxicity test organism for environmental xenobiotic chemicals, and that lethality can be used as a testing endpoint.

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Ellagitannin Toxicity in the Free-Living Soil-Inhabiting Nematode, <i>Caenorhabditis elegans</i>

Cited by 20 publications

References 0 publications

Effects of pine bark supplementation on performance, rumen fermentation, and carcass characteristics of Kiko crossbred male goats1

Effects of pine bark supplementation on performance, rumen fermentation, and carcass characteristics of Kiko crossbred male goats1

Potential anthelmintics: polyphenols from the tea plant Camellia sinensis L. are lethally toxic to Caenorhabditis elegans

Aquatic Acute Toxicity Testing Using the Nematode Caenorhabditis elegans.

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