Ellagic and ferulic acids alleviate gamma radiation and aluminium chloride-induced oxidative damage

Salem, Ahmed M.; Mohammaden, Tarek F.; Ali, Mohamed A.; Mohamed, Enas Ali Kamel; Hasan, Hesham Farouk

doi:10.1016/j.lfs.2016.07.006

Cited by 41 publications

(27 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was accompanied with histological alterations including focal areas of degeneration, congestion and dilated sinusoids. Similar findings were previously reported demonstrating that oxidative stress is induced by radiation 39 , 45 , 46 .…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Radioprotective effect of Date syrup on radiation- induced damage in Rats

Abou‐Zeid

El-Bialy

El-Borai

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Ionizing radiation has cytotoxic and genotoxic effects caused mainly by the oxidative damage induced by free radical release. The need for radioprotectives is increasing to protect normal tissues during radiotherapy. In the present study, we investigated the radioprotective effect of Date syrup in rats subjected to whole body radiation at 6 Gy through biochemical, molecular and histopathological analysis. Significant elevations were recorded in the activities of serum ALT, AST, ALP and LDH and in the levels of all lipid profiles parameters, while the level of HDL-C was reduced. The concentration of liver MDA was elevated with depletion of hepatic glutathione (GSH) and catalase. DNA damage was evidenced by increased DNA strand breakage and DNA-protein crosslinks. Significant elevations were observed in the expression of liver TNF-α and serum activity of matrix metalloproteinase (MMP-9). Pretreatment of rats with Date syrup ameliorated the tissue damage induced by radiation as evidenced by the improvement of liver function, antioxidant status and reduction of DNA damage. Besides, liver TNF-α expression and serum MMP-9 activity were reduced. In conclusion, Date syrup could alleviate the toxic effects of ionizing radiation and thus is useful as a radioprotective in radiotherapy regimen.

show abstract

Section: Discussionsupporting

confidence: 92%

“…Similar findings were previously reported by Mansour 38 and Salem et al . 39 . The elevation of serum transaminases is indicative of hepatocyte injury leading to increase in cell membrane permeability that facilitates the passage of cytoplasmic enzymes to blood.…”

Section: Discussionmentioning

confidence: 99%

Radioprotective effect of Date syrup on radiation- induced damage in Rats

Abou‐Zeid

El-Bialy

El-Borai

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In addition, through its scavenging action on free radicals, ellagic acid indirectly reduced serum level of triglycerides, total cholesterol, and the fraction of LDL and VLDL. These results are in agreement with previous reports showing the hypolipidemic activity ellagic acid [53].…”

Section: Ellagic Acid As An Antioxidant Agentsupporting

confidence: 94%

“…Its intrinsic antioxidant properties have been attributed to its free radical scavenging activity, which has been proposed to be similar to that of essential vitamins. As commented above, the presence of four hydroxyl and two lactone functional groups enables ellagic acid to scavenge a wide variety of ROS and reactive nitrogen species [53]. Indeed, studies show that at physiological pH, ellagic acid in aqueous solution can deactivate not only hydroxyl radical (HO • ), but also peroxyl radicals (ROO • ), nitrogen dioxide (NO 2…”

Section: Ellagic Acid As An Antioxidant Agentmentioning

confidence: 99%

A Pharmacological Update of Ellagic Acid

et al. 2018

View full text Add to dashboard Cite

Ellagic acid is a common metabolite present in many medicinal plants and vegetables. It is present either in free form or as part of more complex molecules (ellagitannins), which can be metabolized to liberate ellagic acid and several of its metabolites, including urolithins. While ellagic acidʼs antioxidant properties are doubtless responsible for many of its pharmacological activities, other mechanisms have also been implicated in its various effects, including its ability to reduce the lipidemic profile and lipid metabolism, alter pro-inflammatory mediators (tumor necrosis factor-α, interleukin-1β, interleukin-6), and decrease the activity of nuclear factor-κB while increasing nuclear factor erythroid 2-related factor 2 expression. These events play an important role in ellagic acidʼs anti-atherogenic, anti-inflammatory, and neuroprotective effects. Several of these activities, together with the effect of ellagic acid on insulin, glycogen, phosphatases, aldose reductase, sorbitol accumulation, advanced glycation end-product formation, and resistin secretion, may explain its effects on metabolic syndrome and diabetes. In addition, results from recent research have increased the interest in ellagic acid, both as a potential protective agent of the liver and skin and as a potential anticancer agent, due to the specific mechanisms affecting cell proliferation, apoptosis, DNA damage, and angiogenesis and its aforementioned anti-inflammatory properties. Taken together, these effects make ellagic acid a highly interesting compound that may contribute to different aspects of health; however, more studies are needed, especially on the compoundʼs pharmacokinetic profile. In this review, we selected papers published from 2005 to the present.

show abstract

“…Furthermore, no change was observed in the expression of the Ki-67 cell proliferation indicator in the kidney or liver tissues, which suggests that LPE did not promote changes in the proliferative activity of these organs. Several studies have reported the protective effects of ellagic acid, the main active compound responsible for the biological effects of LPE, and of other Lythraceae family species on liver (Baravalia, Chanda, 2011;García-Niño, Zazueta, 2015;Kang et al, 2016;Salem et al, 2016) and kidney (Priya, Sabu, Jolly, 2007;Basha, Saumya, 2013; El-Garhy et al, 2014; Ayhanci et al, 2015) injuries triggered by xenobiotic-induced oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Toxicological evaluation of Lafoensia pacari A. St.-Hil. (Lythraceae) stem bark extract: Acute and subchronic studies in mice

Ávila

Ferreira

Alvarenga

et al. 2019

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

This study evaluated the safety of Lafoensia pacari A. St.-Hil. (Lythraceae) stem bark hydroalcoholic extract (LPE) through acute and subchronic toxicological assessments in mice. In the acute toxicity evaluation, a single 2000 mg/kg oral dose of LPE was administered to mice and clinical observations were conducted for 14 days. For subchronic toxicity, LPE doses (6.25-1000 mg/kg) were administered orally for 28 days and biochemical, hematological, histopathological analyses and renal and liver expression of Ki-67 were carried out. The acute oral toxicity evaluation of LPE showed no toxicity in mice and it was was classified as category 5 (LD 50 >2000-5000 mg/kg). In a repeated dose 28-day toxicity study, LPE (100-1000 mg/kg) led to an increase in reticulocytes, which suggests a possible proliferative effect on blood cells. In addition, LPE (400-1000 mg/kg) of produced alterations in biochemical parameters, although no microscopic changes were found in the organs analyzed. A normal expression of the Ki-67 cell proliferation indicator was observed in the kidney and liver tissues, which suggests that LPE does not bring about changes in the proliferative activity of these organs. In conclusion, LPE should be used with caution, particularly in larger doses over longer periods and also in combination with other medication.

show abstract

Ellagic and ferulic acids alleviate gamma radiation and aluminium chloride-induced oxidative damage

Cited by 41 publications

References 73 publications

Radioprotective effect of Date syrup on radiation- induced damage in Rats

Radioprotective effect of Date syrup on radiation- induced damage in Rats

A Pharmacological Update of Ellagic Acid

Toxicological evaluation of Lafoensia pacari A. St.-Hil. (Lythraceae) stem bark extract: Acute and subchronic studies in mice

Contact Info

Product

Resources

About