Radioprotective effect of Date syrup on radiation- induced damage in Rats

Abou‐Zeid, Shimaa M.; El-Bialy, Badr E.; El-Borai, Nermeen Borai; AbuBakr, Huda O.; Elhadary, Abdel Monsef A.

doi:10.1038/s41598-018-25586-3

Cited by 40 publications

(31 citation statements)

References 72 publications

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“…The present investigation suggests that the hemoglobin level follows a same pattern to that of RBC in general. These observations are in agreement with Zeid et al, 18 who reported significant reduction in hemoglobin concentration in Swiss albino mice exposed to 6 Gy gamma radiation. A depression in the hematocrit value can be related to total cell depletion in peripheral blood aided by confusion in steady state mechanisms in blood forming organs as well as an increase in plasma volume after irradiation.…”

Section: Fig 2: Showing Correlation Coefficient Among Various Group supporting

confidence: 93%

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2019

IJPSR

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The modulatory effect of Opuntia elatior stem extract was studied in Swiss albino mice at dose 6 Gy of gamma radiation. Four groups were divided in the presence (experimental) or absence (control) of Opuntia extract 10 mg/kg body wt.) to observe hematological alterations. Four groups are Group I without any treatment as control, Group II treated with 10 mg/kg body weight dose of plant Opuntia elatior extract, Group III treated with Opuntia elatior extract (10 mg/kg body weight) and 6 Gy gamma irradiation dose, Group IV treated with 6 Gy gamma irradiation .These animals were scarified and their blood was collected by heart puncture from the syringe in the EDTA filled viles at days 1, 15 and 30 post-irradiations. There was no variation in RBC and WBC counts including hemoglobin content in the control group (without any treatment); but significantly decreased in 6 Gy gamma irradiation treated group IV, whereas a recovery pattern was recorded in experimental animals (Group II and Group III) and a normal value of hematological parameters were regained by day 30 post-treatment after treatment with plant extracts as compared to radiation group with some variations. Synthetic chemicals were used to as radioprotective agents but because of their high toxicity and side effects, they were not as useful as we thought, so natural products (plant extract) may offer as potential radioprotector due to their low toxicity and side effects.

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Section: Fig 2: Showing Correlation Coefficient Among Various Group supporting

confidence: 93%

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2019

IJPSR

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“…9–11 ROS cause cellular damage by causing adverse effects on antioxidant defense mechanisms by reducing glutathione (GSH) levels and increasing malondialdehyde (MDA) levels. 12,13 Recent studies have also shown that ROS cause damage to DNA and lead to caspase-dependent apoptosis. 14,15 Activation of the caspase-3 cascade plays a highly important role in apoptosis and is regarded as a terminal event prior to cell death and increases under the effect of radiation.…”

Section: Introductionmentioning

confidence: 99%

The effects of N-acetylcysteine on radiotherapy-induced small intestinal damage in rats

Mercantepe

Topçu

Rakıcı

et al. 2019

Exp Biol Med (Maywood)

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Six million cancer patients worldwide receive radiotherapy, either alone or in combination with other cancer treatments annually. The purpose of this study was to investigate, at the structural and molecular levels, the protective effect of N-acetylcysteine (NAC), a powerful antioxidant, against radiotherapy-induced damage on the intestinal system. Three study groups were constituted: control (group 1: no radiotherapy), radiotherapy (RT; group 2), and RT + NAC (group 3). The NAC group received 300 mg/kg NAC orally for five days before irradiation. At the end of the 5th day, 6 Gy was irradiated once, and 300 mg/kg NAC was administered orally for two days following irradiation. NAC drug administration was maintained for a total of seven days. At the end of the study, the rats were euthanized by the administration of anesthetic agents and sacrificed. The malondialdehyde (MDA) levels and caspase-3 expression increased and glutathione (GSH) levels decreased in RT rats compared to the control group ( p < 0.05). NAC reduced MDA levels, and caspase-3 expression, and increased GSH levels in the small intestine caused by RT ( p < 0.05). Therefore, NAC may be useful in the prevention of gastrointestinal syndrome in patients undergoing radiotherapy in the treatment of malignancy. Impact statement Some six million cancer patients currently receive radiotherapy. Radiotherapy eliminates cancer cells by accelerating their death. However, radiotherapy is not selective, and it therefore harms healthy tissues around cancerous tissue. The latest studies have shown that the irradiation of biological materials causes a rapid increase in reactive oxygen species (ROS) in the tissue as a result of exposure of the target molecule to direct and indirect ionization. N-acetylcysteine (NAC) is an antioxidant that permits the elimination of free oxygen radicals and that contributes to glutathione synthesis. Our study, therefore, examined the effects of radiation resulting from radiotherapy on the small intestine at the molecular level, and prospectively considered the potential protective characteristics of NAC against gastrointestinal syndrome resulting from radiotherapy.

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“…Radiation induced (OS) results in oxidation of protein, lipids and nucleotides (Sarhanand & Naoum, 2020). Therefore ionizing radiation is known to induce mutations and cell transformations through single and double strand DNA breakage leading to produce chromosomal instability and carcinogenesis (Vorobtsova, 2000;Bàlentovà et al, 2008;Abou-Zeid et al, 2018). Clear dose rate effects were observed in MNPCEs and CAs frequencies in mice and rats (Tanaka et al .,2008;Pillai & Devi, 2013;Bagheri et al,2018).…”

Section: Introductionmentioning

confidence: 99%

Radio-protective role of interferon and fenugreek on γ- radiation induced DNA instability

Sweify

Mosallam

IbrahimA.

et al. 2020

African Journal of Biological Sciences

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The radio-protective role of fenugreek (fen) and IFN was studied against the damage effects induced by gamma irradiation in liver of albino rats. Male and female albino rats were paired. The produced generations were separated into 3 classes PC, PT& P-ir, representing untreated, fed with standard food mixed with 5% Fen seed powder (FSP) and exposed to whole body irradiation (WBI) respectively. Animals were allowed for mating to give F 1. F 1 was separated into 3 subgroups (ir-ir), (ir+FSP) and (ir-IFN), subjected to another dose of irradiation, fed with standard food mixed with FSP, injected with IFN respectively. All individuals were arranged for pairing until the production of F 2. DNA assay was carried out using RAPD-PCR fingerprinting technique. Six arbitrary primers were used. They produced various numbers of fractions ranging between zero to 8 within each of the studied groups. Some specific fractions were picked out indicating polymorphic alleles. Quantitative mutations were observed within the percentage area of the generated bands. Highest and / or lowest similarity indices were observed between the studied groups indicating complementary to the used primer or pointing to some degree or to complete disturbance in the DNA sequencing as a result of the different treatments. In conclusion the remarked changes in DNA fingerprinting confirmed the potential transmission of radiation damage of genome to the progeny while each of fen and IFN ameliorated the harmful effects of irradiation.

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Radioprotective effect of Date syrup on radiation- induced damage in Rats

Cited by 40 publications

References 72 publications

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The effects of N-acetylcysteine on radiotherapy-induced small intestinal damage in rats

Radio-protective role of interferon and fenugreek on γ- radiation induced DNA instability

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