Ellagic Acid Enhances the Antitumor Efficacy of Bevacizumab in an In Vitro Glioblastoma Model

Çetin, Abdurrahman; Biltekin, Burcu; Değirmencioğlu, Sevgin

doi:10.1016/j.wneu.2019.08.257

Cited by 10 publications

(8 citation statements)

References 25 publications

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“…It is more toxic in tumor cells than in normal cells and has been reported to inhibit the activity of the X family polymerases (b and l), affecting the base excision repair pathway and making various cancer cells more susceptible to the effect of bleomycin and temozolomide (94). Ellagic acid obtained from various fruits and vegetables is a polyphenolic compound that can reduce MGMT expression in glioblastoma cells and together with antiangiogenic therapy with bevacizumab (which also affects DNA repair by reducing the expression of ERCC-1 and XRCC-1) improves the radiosensitivity of tumors (95,96). Celastrol is a polyphenolic compound isolated mainly from plants in the Celastraceae family.…”

Section: Other Compoundsmentioning

confidence: 99%

Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells

Lagunas‐Rangel

Bermúdez‐Cruz

2020

Front. Oncol.

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Resistance to current cancer treatments is an important problem that arises through various mechanisms, but one that stands out involves an overexpression of several factors associated with DNA repair. To counteract this type of resistance, different drugs have been developed to affect one or more DNA repair pathways, therefore, to test different compounds of natural origin that have been shown to induce cell death in cancer cells is paramount. Since natural compounds target components of the DNA repair pathways, they have been shown to promote cancer cells to be resensitized to current treatments. For this and other reasons, natural compounds have aroused great curiosity and several research projects are being developed around the world to establish combined treatments between them and radio or chemotherapy. In this work, we summarize the effects of different natural compounds on the DNA repair mechanisms of cancer cells and emphasize their possible application to re-sensitize these cells.

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Section: Other Compoundsmentioning

confidence: 99%

Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells

Lagunas‐Rangel

Bermúdez‐Cruz

2020

Front. Oncol.

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“…C6 glioma cells were purchased from the American Type Culture Collection (Manassas, VA, USA), and all procedures were in accordance with steps described in previous studies 13 , 14 .…”

Section: Methodsmentioning

confidence: 99%

“…To determine the immunoreactivities of E-cadherin, N-cadherin, and VEGF, all steps of immunocytochemistry (ICC) and H-SCORE analysis described in previous studies were applied in this study 13 , 14 .…”

Section: Methodsmentioning

confidence: 99%

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Antitumor activity of irinotecan with ellagic acid in C6 glioma cells

Çetin

Biltekin

Özevren

2022

Rev. Assoc. Med. Bras.

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OBJECTIVE:Irinotecan-based combination chemotherapies in malignant gliomas need to be examined. The aim of this study was to investigate the synergetic effect of ellagic acid, a natural polyphenolic antioxidant compound, with irinotecan, an inhibitor of topoisomerase I enzyme, on the growth, cadherin switch, and angiogenic processes of a glioma cell line. METHODS: A combination of 100 μM ellagic acid and 100 μM irinotecan was applied to rat C6 glioma cells for 24th, 48th, and 72nd h. The cell proliferation was evaluated by 5-bromo-2ʹ-deoxyuridine immunocytochemistry. The expression levels of vascular endothelial growth factor, E-cadherin, and N-cadherin were measured using real-time polymerase chain reaction and their immunoreactivities using immunocytochemistry. RESULTS: The treatment of irinotecan with combining ellagic acid enhanced antitumor activity and the synergistic effect of these reduced the cell proliferation of C6 glioma by inhibiting the cadherin switch and promoting the antiangiogenic processes. CONCLUSIONS: Further research is required to prove a negative relationship between C6 glial cell proliferation and irinotecan with ellagic acid application. Our preliminary data suggest that even with the extremely short-term application, irinotecan with ellagic acid may affect glioma cells at the level of gene and protein expression.

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“…This encapsulation improved the oral bioavailability and the anti-tumor effect of ellagic acid. In a glioblastoma model, Cetin, et al carried out two studies that showed an improvement in the anticancer efficacy of bevacizumab [ 64 ] and TMZ [ 65 ] by co-treatment with ellagic acid. This treatment reduced the expression of MGMT, affected caspase-3 and p53 proteins, and its combination with the chemotherapeutics reduced cell viability and the expression of MDR1.…”

Section: Dietary Phenolic Compounds Improving the Chemosensitivity Of...mentioning

confidence: 99%

Advances in Dietary Phenolic Compounds to Improve Chemosensitivity of Anticancer Drugs

Bouyahya

Omari

Bakrim

et al. 2022

Cancers

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Despite the significant advances and mechanistic understanding of tumor processes, therapeutic agents against different types of cancer still have a high rate of recurrence associated with the development of resistance by tumor cells. This chemoresistance involves several mechanisms, including the programming of glucose metabolism, mitochondrial damage, and lysosome dysfunction. However, combining several anticancer agents can decrease resistance and increase therapeutic efficacy. Furthermore, this treatment can improve the effectiveness of chemotherapy. This work focuses on the recent advances in using natural bioactive molecules derived from phenolic compounds isolated from medicinal plants to sensitize cancer cells towards chemotherapeutic agents and their application in combination with conventional anticancer drugs. Dietary phenolic compounds such as resveratrol, gallic acid, caffeic acid, rosmarinic acid, sinapic acid, and curcumin exhibit remarkable anticancer activities through sub-cellular, cellular, and molecular mechanisms. These compounds have recently revealed their capacity to increase the sensitivity of different human cancers to the used chemotherapeutic drugs. Moreover, they can increase the effectiveness and improve the therapeutic index of some used chemotherapeutic agents. The involved mechanisms are complex and stochastic, and involve different signaling pathways in cancer checkpoints, including reactive oxygen species signaling pathways in mitochondria, autophagy-related pathways, proteasome oncogene degradation, and epigenetic perturbations.

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Ellagic Acid Enhances the Antitumor Efficacy of Bevacizumab in an In Vitro Glioblastoma Model

Cited by 10 publications

References 25 publications

Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells

Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells

Antitumor activity of irinotecan with ellagic acid in C6 glioma cells

Advances in Dietary Phenolic Compounds to Improve Chemosensitivity of Anticancer Drugs

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