Ellagic Acid and Derivatives from Cochlospermum angolensis Welw. Extracts: HPLC–DAD–ESI/MSn Profiling, Quantification and In Vitro Anti‐depressant, Anti‐cholinesterase and Anti‐oxidant Activities

Ferreres, Federico; Grosso, Clara; Gil‐Izquierdo, Ángel; Valentão, Patrı́cia; Andrade, Paula B.

doi:10.1002/pca.2429

Cited by 49 publications

(47 citation statements)

References 36 publications

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“…Similarly, erythrocytes obtained from mice infected with P. berghei , showed immediate inhibition of parasite DNA replication and protein expression after exposure to borututu extract [4]. In a recent study, Ferreres et al demonstrated a significant antioxidant activity of different borututu extracts, which was attributed to ellagic acid and related analogs [5]. Similarly, Pereira et al showed that a boiling water infusion of borututu bark showed antioxidant and antitumor activity [2].…”

Section: Introductionmentioning

confidence: 99%

Hydroxybenzoic Acids Are Significant Contributors to the Antioxidant Effect of Borututu Bark, Cochlospermum angolensis Welw. ex Oliv

Abourashed

2017

Antioxidants

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Borututu (Cochlospermum angolensis) is an African tree whose bark has recently emerged as a herbal dietary supplement with claims for antioxidant activity. In order to substantiate the claimed activity of borututu supplements, we performed an activity-guided fractionation of the total extract utilizing a 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. Subsequent flash and centrifugal chromatography resulted in the isolation of gallic acid (1) and protocatechuic acid (2) as the main antioxidant constituents. Two apocarotenoids and one flavonoid were also isolated from the chloroform fraction and were identified as cochloxanthin (3), dihydrocochloxanthin (4), and 7,4′-dimethyltaxifolin (5), respectively. A High-performance liquid chromatography (HPLC) method was also developed for fingerprinting borututu samples, with Compounds 1–4 suggested as chemical markers for quality control purposes.

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Section: Introductionmentioning

confidence: 99%

Hydroxybenzoic Acids Are Significant Contributors to the Antioxidant Effect of Borututu Bark, Cochlospermum angolensis Welw. ex Oliv

Abourashed

2017

Antioxidants

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“…Indeed, the chemical composition of these plants is not constant and the presence of chemicals that claims to have medicinal benefits (active principals) depends on a number of factors including the plant species, the time and season of harvest, the type of soil, the way the herb is prepared, etc. (Ferreres et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Synergisms in antioxidant and anti-hepatocellular carcinoma activities of artichoke, milk thistle and borututu syrups

Pereira¹,

Calhelha²,

Barros³

et al. 2014

Industrial Crops and Products

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Artichoke, borututu and milk thistle are three medicinal plants well-known for their capacity to prevent oxidative stress and many liver diseases. In a previous work, we reported the bioactivity of infusions and pills based on these plants; herein, the aim was to provide scientific information about the antioxidant and anti-hepatocellular carcinoma activities of syrups based on these medicinal plants and evaluate the synergism among the combined plants by using syrups based on the mixed plants or prepared form the combinations of individual species. The antioxidant activity was measured by radical scavenging activity, reducing power and lipid peroxidation inhibition, while the anti-hepatocellular carcinoma activity and the hepatotoxicity were evaluated using HepG2 human cell line and a primary culture of porcine liver cells, respectively. Milk thistle syrup proved to have the highest antioxidant activity in all the assayed methods, providing the best results either in single syrup or included in mixed syrups. Synergistic effects were the main interactions observed in the mixture of artichoke, borututu and milk thistle; mixing the syrups based on each single plant proved to be more efficient regarding antioxidant proposals than mixing plants in the same syrup. The latter was advantageous for anti-hepatocellular carcinoma activity.

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“…Nevertheless and despite the high consumption of those plants, the studies on nutritional value and primary metabolites are scarce, being only reported their phytochemical composition in non-nutrients such as phenolic compounds (Kukić et al 2008;Wang et al 2010;Abu-Reidah et al 2013;Ferreres et al 2013). …”

Section: Introductionmentioning

confidence: 99%

Analytical Tools Used to Distinguish Chemical Profiles of Plants Widely Consumed as Infusions and Dietary Supplements: Artichoke, Milk Thistle, and Borututu

2014

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Artichoke, borututu and milk thistle are three medicinal plants widely consumed as infusions or included in dietary supplements (e.g., pills and syrups). Despite their high consumption, studies on nutritional value and primary metabolites are scarce, being only reported the composition in secondary metabolites such as phenolic compounds.Therefore, their nutritional value was assessed and analytical tools (liquid and gas chromatography coupled to different detectors) were used to distinguish the chemical profiles namely in hydrophilic (sugars and organic acids) and lipophilic (fatty acids and tocopherols) compounds. Chromatographic techniques are important analytical tools used in the identification and quantification of several molecules, also being a standard requirement to distinguish different profiles. Borututu gave the highest energetic value with the highest content of carbohydrates and fat, sucrose and total sugars, shikimic and citric acids, α-, β-, δ-and total tocopherols. Artichoke had the highest ash and protein contents, oxalic acid, SFA (mainly palmitic acid acid), and γ-tocopherol, as also the best

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Ellagic Acid and Derivatives from Cochlospermum angolensis Welw. Extracts: HPLC–DAD–ESI/MSⁿ Profiling, Quantification and In Vitro Anti‐depressant, Anti‐cholinesterase and Anti‐oxidant Activities

Abstract: The results provided evidence of the value of C. angolensis as a source of health-promoting anti-oxidants and anti-depressant compounds, with potential to be used as a raw product for food and pharmaceutical industries.

Cited by 49 publications

References 36 publications

Hydroxybenzoic Acids Are Significant Contributors to the Antioxidant Effect of Borututu Bark, Cochlospermum angolensis Welw. ex Oliv

Hydroxybenzoic Acids Are Significant Contributors to the Antioxidant Effect of Borututu Bark, Cochlospermum angolensis Welw. ex Oliv

Synergisms in antioxidant and anti-hepatocellular carcinoma activities of artichoke, milk thistle and borututu syrups

Analytical Tools Used to Distinguish Chemical Profiles of Plants Widely Consumed as Infusions and Dietary Supplements: Artichoke, Milk Thistle, and Borututu

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