Elimination of pain-induced aggression in male mice following olfactory bulb removal

Fortuna, Michael B.; Gandelman, Ronald

doi:10.1016/0031-9384(72)90166-7

Cited by 12 publications

(3 citation statements)

References 8 publications

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“…It is known that olfaction is important in mediation of aggressive behavior and that removal of the olfactory bulb leads to a complete absence in spontaneous aggression in mice (Ropartz, 1968, Fortuna and Gandelman, 1972). In the current study MCHKO mice were found to be significantly more aggressive towards intruder mice than WT in the resident intruder paradigm.…”

Section: Discussionmentioning

confidence: 99%

Ablation of the hypothalamic neuropeptide melanin concentrating hormone is associated with behavioral abnormalities that reflect impaired olfactory integration

Adams

Domouzoglou

Chee

et al. 2011

Behavioural Brain Research

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Melanin-concentrating hormone (MCH) is an orexigenic hypothalamic neuropeptide. At least one receptor, MCH receptor 1 (MCHR1), is present in all mammals and is expressed widely throughout the brain, including cortex, striatum and structures implicated in the integration of olfactory cues such as the piriform cortex and olfactory bulb. Consistent with a potential role for MCH in mediating olfactory function, MCH knockout mice demonstrate abnormal olfactory behaviors. These behaviors include impaired food seeking by both genders while maintaining normal levels of locomotion, suggesting impaired olfaction. Males also exhibit increased aggression while females show defects in several olfactory mediated behaviors including mating, estrous cycle synchronization and maternal behavior. These findings suggest that hypothalamic inputs through MCH play an important role in regulating sensory integration from olfactory pathways.

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Section: Discussionmentioning

confidence: 99%

Ablation of the hypothalamic neuropeptide melanin concentrating hormone is associated with behavioral abnormalities that reflect impaired olfactory integration

Adams

Domouzoglou

Chee

et al. 2011

Behavioural Brain Research

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show abstract

“…Bulbectomy in male mice completely abolishes spontaneous and shock-induced intraspecific aggression (Fortuna & Gandelman, 1972;Ropartz, 1968;Rowe & Edwards, 1971). Given the presence of an aggressionpromoting pheromone in this species (Mugford & Nowell, 1971), it is reasonable to suppose that bulbectomy eliminates aggressive behavior by preventing the pheromone from being sensed.…”

Section: Aggressionmentioning

confidence: 99%

The role of the olfactory bulb in limbic mechanisms.

Cain

1974

Psychological Bulletin

159

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Recent data obtained after peripheral olfactory system damage, when compared with bulbectomy data, suggest that the olfactory bulb has certain general modulatory functions, in addition to its specific sensory role as initial processor of olfactory information. It is proposed that the olfactory bulb is involved in a forebrain arousal mechanism comprised mainly of hypothalamus and limbic system. Behavioral and electrophysiological evidence is reviewed that supports the idea that the olfactory bulb may modulate the excitability of forebrain regions. Anatomical details of the system are considered, and its relationship to reinforcement mechanisms and to the Arousal System II of Routtenberg is outlined. 'Most studies aimed at elucidating the extent to which behavior is dependent on and guided by olfactory information have made use of the technique of olfactory bulbectomy to produce anosmia, or inability to smell. This approach rests on the assumption that the olfactory bulb is exclusively a sensory relay structure whose only action is to transmit neuronal activity from the olfactory receptors to higher olfactory centers. Adherence to this view, which is apparently widespread but often not stated explicitly, is evident in terminology that refers to the olfactory bulb as the "olfactory afferent" and bulbectomy as olfactory "deafferentation" (Aron, Roos, & Asch, 1970;Karli, Vergnes, & Didiergeorges, 1969;LaRue & LeMagnen, 1972), a misuse of the latter term, which properly refers to the interruption of primary sensory nerve fibers (Blakiston's Medical Dictionary, 1972). Complete bilateral bulbectomy destroys roughly 4% of central nervous tissue rostral to spinal cord in the rat.

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“…In support of this interpretation are data showing that temporary odor masking of both members of a pair of male mice produce an increase in the latency to exhibit attack behavior as well as a decrease in the number of pairs of animals that fight (Fortuna & Gandelman, 1972;Ropartz, 1968). However, by utilizing zinc sulfate for peripherally inducing anosmia, Edwards, Thompson, and Burge (1972) have clearly demonstrated that the perception of pheromonal stimuli is not a necessary condition for the elicitation of intramale spontaneous aggression.…”

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confidence: 90%

Elicitation of aggression by food deprivation in olfactory bulbectomized male mice

Fortuna

1977

Psychobiology

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Two experiments were conducted in order to examine the necessary conditions for the elicitation of competitive aggression in olfactory bulbectomized male mice. Experiment 1 compared the fighting produced among pairs of bulbectomized males under either food deprivation or ad-lib feeding, with and without the presence of a food-pellet/competition-eliciting stimulus. Animals fought when food-deprived but not when sated. The presence of a food pellet was not necessary for the promotion of aggression. Experiment 2 sought to remove the condition of isolation in pretest housing. However, when bulbectomized males, housed in pairs, were placed upon a food-deprivation schedule, one member was inevitably cannibalized. Identically treated controls died before exhibiting any cases of cannibalism. These findings indicate that the condition of food deprivation is sufficient to reinstate intraspecific aggression in bulbectomized male mice, as well as combine with the effects of bulbectomy to promote normally inhibited cannibalism.

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Elimination of pain-induced aggression in male mice following olfactory bulb removal

Cited by 12 publications

References 8 publications

Ablation of the hypothalamic neuropeptide melanin concentrating hormone is associated with behavioral abnormalities that reflect impaired olfactory integration

Ablation of the hypothalamic neuropeptide melanin concentrating hormone is associated with behavioral abnormalities that reflect impaired olfactory integration

The role of the olfactory bulb in limbic mechanisms.

Elicitation of aggression by food deprivation in olfactory bulbectomized male mice

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