The role of the olfactory bulb in limbic mechanisms.

Cain, Donald P.

doi:10.1037/h0036954

Cited by 159 publications

(55 citation statements)

References 126 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding can be viewed as consistent with Cain's (1974) hypothesis that the olfactory bulbs may participate in a forebrain arousal circuit. During baitshyness acquisiton, the bulbs may normally facilitate the association of gustatory cues with visceral distress through its arousal function, a function not critical for maintaining already established aversions .…”

Section: Methodssupporting

confidence: 78%

“…It is important to emphasize that the specific nature of nonsensory olfactory-bulb contributions to taste aversion conditioning remains to be determined. Cain's (1974) arousal hypothesis is advanced simply to illustrate one of the possibilities that could integrate current acquisition and retention data.…”

Section: Methodsmentioning

confidence: 99%

“…This evidence, reviewed by Cain (1974), rests primarily upon the ob servation that peripherally induced anosmia frequently does not result in the same behavioral changes as those produced by direct surgical insult to the olfactory bulbs. With respect to the acquisition of aversions to flavor s which have been paired with internal malaise (bait shyness), at least partial attenuation results from bilateral olfactory-bulb lesions in both rats and ham ster s, even if the posterior bulbar layers are spared (e.g., Dine & Smith, 1966;Hankins, Garcia, & Rusiniak, 1973;Hobbs, Clingerman & Elkins, 1976;Elkins & Hobbs, Note I).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Baitshyness retention in rats with olfactory-bulb ablations

Hobbs¹,

Elkins

1976

Psychobiology

View full text Add to dashboard Cite

Section: Methodssupporting

confidence: 78%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Baitshyness retention in rats with olfactory-bulb ablations

Hobbs¹,

Elkins

1976

Psychobiology

View full text Add to dashboard Cite

“…In male mice and hamsters, bilateral removal of the olfactory bulbs eliminates copulation [321. It has been suggested that these mating behavior deficits and effects on other behaviors observed in a variety of species are due to disruption of non-sensory limbic system circuits rather than to removal of the sense of smell [7,14]. Bulbectomy, as it is usually accomplished, destroys the interconnections between the olfactory bulbs and areas of the basal forebrain and brain stem [9, I 1, 38].…”

Section: Hamstermentioning

confidence: 99%

Olfactory and vomeronasal system participation in male hamsters' attraction to female vaginal secretions

Powers

Fields

Winans

1979

Physiology & Behavior

101

View full text Add to dashboard Cite

POWERS, J. B., R. B. FIELDS AND S. S. WINANS. O~wtory and vomeronasal system participation in male hamsters' attraction to ./bmc:/e vaginal secrethms. PHYSIOL. BEHAV. 22(I) 77--84, 1979.~The effects of olfactory (OLF) vomeronasal (VN), or combined deafferentations of male hamsters on their attraction to female hamster vaginal secretions (FHVS) were determined using 2 different attraction tests. In the first, FHVS was placed on one wall of a plastic test chamber, while in the second test, FHVS was rubbed onto 1 of 2 anesthetized castrate hamsters. OLF deafferentation abolished the males" attraction to FHVS in the first test but had no effect in the second. The persistence of FHVS attraction in the anesthetized castrate test depended on the VN system in that its subsequent deafferentation greatly attenuated the attraction. When the VN system was deafferented alone, FHVS attraction was significantly reduced only in males exhibiting severe mating behavior deficits. These results are interpreted to support the hypothesis that the OLF and VN systems may be preferentially responsive to volatile and non-volatile odorants, respectively. Our findings emphasize that both the OLF and VN systems participate in subserving males' attraction to FHVS and their mating with receptive females. Thus each chemosensory system may influence both sexual arousal and copulatory mechanisms. HamsterCopulation Olfactory/vomeronasal system Sexual attraction Vaginal secretions CHEMOSENSORY stimuli are important regulators of sexual behavior among a number of vertebrate classes [13,29]. The effects of these stimuli combine with those derived from other sensory and behavioral cues to initiate and coordinate reproductive interactions between male and female conspecifics. There are very few species in which one sensory modality can be singled out as crucial to reproductive activities; however, in some rodents the chemosensory modality would appear dominant. In male mice and hamsters, bilateral removal of the olfactory bulbs eliminates copulation [321. It has been suggested that these mating behavior deficits and effects on other behaviors observed in a variety of species are due to disruption of non-sensory limbic system circuits rather than to removal of the sense of smell [7,14]. Bulbectomy, as it is usually accomplished, destroys the interconnections between the olfactory bulbs and areas of the basal forebrain and brain stem [9, I 1, 38]. This procedure also destroys afferents from the olfactory mucosa to the main olfactory bulb (MOB), connections of the vomeronasal organ (VNO) with the accessory olfactory bulb (AOB), the nerves of the septal olfactory organ and the nervus terminalis [2,5]. Although the contribution which each of these systems might make to the behavioral effects of bulbectomy in any species has not been ascertained, recent work in this laboratory has indicated that the olfactory and vomeronasal systerns together comprise an essential substrate in the regulation of male hamster copulation [36,42]. Although deafferentation of th...

show abstract

“…CONSIDERABLE discussion in recent years has centered on the question of whether and under what conditions differential effects are produced by removal of the olfactory bulbs as opposed to removal or inactivation of the main olfactory receptors in the nasal cavities (see Alberts [1], Cain [4], Edwards [7] and Murphy [17] for reviews). Spector and Hull [20], Alberts and Friedman [2] and others have reported increased mouse killing by bulbectomized animals but not those rendered anosmic by peripheral manipulations.…”

mentioning

confidence: 99%