Elimination of erythromycin in milk after intramammary administration in cows with specific mastitis: relation to dose, milking frequency and udder health

Bansal, B. K.; Bajwa, N. S.; Randhawa, S. S.; Ranjan, Rakesh; Dhaliwal, P. S.

doi:10.1007/s11250-010-9692-1

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…Individual physiological differences between animals such as age, lactation stage, hormone synthesis and milk production interfere with the absorption and excretion rates of antibiotic residues in milk, provoking oscillations in the elimination of these drugs. These differences are more evident in mammary quarters with mastitis compared to healthy mammary quarters (Bansal et al 2011). In the latter, the variations are due to the physiology of the animal and mammary quarter itself, whereas additional factors exist in animals with mastitis which are related to the pathological state of the gland (Lucas et al 2009).…”

Section: Gentamicin Residues In Milkmentioning

confidence: 97%

“…However, treatment of animals according to manufacturer recommendations has been shown to be insufficient to prevent antibiotic residues in milk after the withdrawal period (McEwen et al 1992). Considerable variation exists in the concentration of antibiotics in milk from different cows and even between mammary quarters of the same animal (Smith et al 2004, Bansal et al 2011. Individual physiological differences between animals such as age, lactation stage, hormone synthesis and milk production interfere with the absorption and excretion rates of antibiotic residues in milk, provoking oscillations in the elimination of these drugs.…”

Section: Gentamicin Residues In Milkmentioning

confidence: 99%

“…In some cases, detection of antibiotic residues can be attributed to the persistence of these drugs in milk beyond the recommended withdrawal period (Bansal et al 2011).…”

Section: Introductionmentioning

confidence: 99%

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Intramammary treatment with gentamicin in lactating cows with clinical and subclinical mastitis

et al. 2016

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The study evaluated the microbiological profile of milk samples collected before and after mastitis treatment with gentamicin and investigated biofilms production and antimicrobial susceptibility of Staphylococcus spp. isolated. The presence of gentamicin residues in milk after the recommended withdrawal period was also evaluated. Antimicrobial residues were analyzed by Delvotest® SP NT over a period of 12 days beginning after 24 hours the last gentamicin application. Some of Staphylococcus spp. isolates were biofilm producers (19.05%). Staphylococcus spp. showed high levels of resistance to neomycin (16.95%), penicillin G (10.17%), and ampicillin (10.17%). Multidrug resistance to all antibiotics tested was observed in 1.69% of the Staphylococcus spp. isolates. Among 1440 mammary quarter milk samples 24.95% presented gentamicin residues after the withdrawal period. Gentamicin residues were also detected in 3.8% of samples from calibrated glass recorder jar (n=383) 4.1 days after treatment. The indiscriminate use of antibiotics may lead to the emergence of multidrug-resistant strains as well as increasing the risk of presence of residues of these drugs in milk. These problems affect the milk quality and may become a public health problem.

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Section: Gentamicin Residues In Milkmentioning

confidence: 97%

Section: Gentamicin Residues In Milkmentioning

confidence: 99%

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Intramammary treatment with gentamicin in lactating cows with clinical and subclinical mastitis

et al. 2016

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“…In India, the economic losses incurred due to mastitis have shown tremendous increase during the last five decades and lately the annual losses due to mastitis have been estimated to the tune of Rs. 7165.51 crore (Bansal et al 2011). Since mastitis affects the milk quality, its consequences are not just restricted to the dairy farm but expand beyond that.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulation of IL-1, IL-6 and IL-8 cytokines by Prosopis juliflora alkaloids during bovine sub-clinical mastitis

et al. 2018

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The current work is focused on establishing therapeutic protocol using unconventional drugs of herbal origin and studying their mechanism of action at molecular level in the treatment of bovine sub-clinical mastitis. It explores the potential of different cytokines which can be used for diagnosis, prognosis and monitoring of bovine sub-clinical mastitis. alkaloids was administered intramammarily in 24 sub-clinically affected quarters once a day for 5 consecutive days at the rate of 10 ml of 1% formulation. In 18 disease control quarters, sterile normal saline was infused. The bacterial cultural examination, somatic cell count (SCC) and cytokines (IL-1β, IL-6, IL-8, IL-12, GM-CSF, IFN-γ, TNF-α) expression by real-time PCR were evaluated on day 7, 14, 21 and 28 post-last treatment from milk samples. Around 75.0% of treatment group quarters showed significant ( < 0.05) reduction in SCC on day 28 post-last treatment, whereas 94.4% control group quarters did not show any significant decline in SCC. 58.3% of treated quarters showed both bacteriological cure as well as significant ( < 0.05) reduction in SCC on day 28 post-last treatment. While, among control group quarters, 83.3% quarters not only remained bacteriological positive, they also did not show any significant decline in SCC. The in vitro antimicrobial activity of alkaloids of was evaluated. Lower concentrations of alkaloids (0.25% and 0.50%) dissolved in normal saline showed zone of inhibition against 12 out of 15 isolates, however higher concentration (1, 1.5, 2, 2.5 and 5%) showed zone of inhibition against all 15 bacterial isolates. The gene expression level of IL-1β, IL-8 and IFN-γ cytokines exhibited significant difference between healthy and sub-clinically affected quarters highlighting the potential of these cytokines in the diagnosis of bovine sub-clinical mastitis. Down-regulation of IL-1, IL-6, IL-8 and IFN-γ cytokines in treated quarters can be explored for making the prognosis and monitoring post-treatment disease progression of bovine sub-clinical mastitis. The alkaloid demonstrated strong in vitro and in vivo antibacterial activity, along with causing immunomodulation by enhancing post-treatment gene expression of IL-1, IL-6 and IL-8 cytokines. Therefore, alkaloids hold a strong claim as an effective alternative herbal therapy in bovine sub-clinical mastitis.

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Daily ingestion of tetracycline residue present in pasteurized milk: a public health problem

Fernandes

Magnavita

Ferrão

et al. 2013

Environ Sci Pollut Res

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The objective of this study was to evaluate (qualitatively and quantitatively) the occurrence of antibiotic residue in pasteurized milk in Brazil. Pasteurized milk samples (n = 252) were collected monthly from Nov. 2010-Oct. 2011 from 21 commercial establishments (brands). A screening test (Delvotest® SP-NT) was applied to those samples. In positive (n = 19) and/or suspect samples (n = 24), we quantified oxytetracycline (OTC) and tetracycline (TC) by high-performance liquid chromatography with diode array detector (HPLC-DAD). OTCs were detected in all positive samples and TCs in six. In the 24suspected samples, OTCs were detected in 23 and TCs were not found in 8. Of the milk brands evaluated (n = 21), the presence of antibiotic residue was not detected in 4; in the other brands, both positive and suspect samples were verified. Results indicate the presence of antibiotic residue above legal limits. According to actual milk consumption in Brazil (441 mL/kg BW/day), in only 9 of the 17 brands of milk with antibiotic residue, the estimated daily intake was at or less than the maximum recommended by the European Union. The screening test used was effective to identify the presence of antibiotic residue (OTC and TC), confirmed by HPLC-DAD. The OTC is the predominant antimicrobial used by dairy farmers. Ingestion of contaminated milk by OTC and TC can increase the resistance of microorganisms to antibiotics.

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Elimination of erythromycin in milk after intramammary administration in cows with specific mastitis: relation to dose, milking frequency and udder health

Cited by 5 publications

References 13 publications

Intramammary treatment with gentamicin in lactating cows with clinical and subclinical mastitis

Intramammary treatment with gentamicin in lactating cows with clinical and subclinical mastitis

Immunomodulation of IL-1, IL-6 and IL-8 cytokines by Prosopis juliflora alkaloids during bovine sub-clinical mastitis

Daily ingestion of tetracycline residue present in pasteurized milk: a public health problem

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