Elimination of a closed population of the yellow fever mosquito, Aedes aegypti, through releases of self-limiting male mosquitoes

Patil, Prabhakargouda B; Dasgupta, S.; Gorman, Kevin; Pickl‐Herk, Angela; Puinean, Mirel; McKemey, Andrew R.; Char, Bharat; Zehr, Usha B.; Barwale, Shirish R

doi:10.1371/journal.pntd.0010315

Cited by 4 publications

(5 citation statements)

References 36 publications

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“…Repeated mating in the field leads to a decline in females and, subsequently, a potential population crash. RIDL has been used successfully to control lepidopteran pests of agriculture and vector mosquitoes in cage studies and in the field [ 122 , 178 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 ].…”

Section: Effective “Green” Technologiesmentioning

confidence: 99%

The Perpetual Vector Mosquito Threat and Its Eco-Friendly Nemeses

Miranda,

Rudd,

Mena

et al. 2024

Biology

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Mosquitoes are the most notorious arthropod vectors of viral and parasitic diseases for which approximately half the world’s population, ~4,000,000,000, is at risk. Integrated pest management programs (IPMPs) have achieved some success in mitigating the regional transmission and persistence of these diseases. However, as many vector-borne diseases remain pervasive, it is obvious that IPMP successes have not been absolute in eradicating the threat imposed by mosquitoes. Moreover, the expanding mosquito geographic ranges caused by factors related to climate change and globalization (travel, trade, and migration), and the evolution of resistance to synthetic pesticides, present ongoing challenges to reducing or eliminating the local and global burden of these diseases, especially in economically and medically disadvantaged societies. Abatement strategies include the control of vector populations with synthetic pesticides and eco-friendly technologies. These “green” technologies include SIT, IIT, RIDL, CRISPR/Cas9 gene drive, and biological control that specifically targets the aquatic larval stages of mosquitoes. Regarding the latter, the most effective continues to be the widespread use of Lysinibacillus sphaericus (Ls) and Bacillus thuringiensis subsp. israelensis (Bti). Here, we present a review of the health issues elicited by vector mosquitoes, control strategies, and lastly, focus on the biology of Ls and Bti, with an emphasis on the latter, to which no resistance has been observed in the field.

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Section: Effective “Green” Technologiesmentioning

confidence: 99%

The Perpetual Vector Mosquito Threat and Its Eco-Friendly Nemeses

Miranda,

Rudd,

Mena

et al. 2024

Biology

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“…In addition, SIT values have been updated in Figures 4,5,and 6, added to Supplementary Figure 2, and the SIT literature source has been added to Supplementary Table 1.…”

Section: 211mentioning

confidence: 99%

“…The previous analyses used 60% at 5-weeks and 95% 10-weeks and this update has only caused small changes in the population dynamics and have not altered the overall trends or our findings. In addition, Male Wolbachia values have been updated in Figures 4,5,and 6, added to Supplementary Figure 2, and the literature source for Male Wolbachiarelease has been updated in Supplementary Table 1.…”

Section: Data Availabilitymentioning

confidence: 99%

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Using models and maps to inform Target Product Profiles and Preferred Product Characteristics: the example of Wolbachia replacement

Tiley,

Entwistle,

Thomas

et al. 2024

Gates Open Res

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Background The global prevalence of diseases transmitted by Aedes aegypti mosquitoes, such as dengue, Zika and Yellow Fever, is increasing, but development of promising new mosquito control technologies could reverse this trend. Target Product Profiles (TPPs) and Preferred Product Characteristics (PPCs) documents issued by the World Health Organization can guide the research and development pathways of new products and product combinations transitioning from proof of concept to operational use. Methods We used high resolution global maps of the case and economic burden of dengue to derive programmatic cost targets to support a TPP for Wolbachia replacement. A compartmental entomological model was used to explore how release size, spacing and timing affect replacement speed and acceptability. To support a PPC for a hybrid suppress-then-replace approach we tested whether Wolbachia replacement could be achieved faster, more acceptably or at a lower cost if preceded by a mosquito suppression programme. Results We show how models can reveal trade-offs, identify quantitative thresholds and prioritise areas and intervention strategies for further development. We estimate that for Wolbachia replacement to be deployable in enough areas to make major contributions to reducing global dengue burden by 25% (in line with 2030 WHO targets), it must have the potential for cost to be reduced to between $7.63 and $0.24 (USD) per person protected or less. Suppression can reduce the number of Wolbachia mosquitoes necessary to achieve replacement fixation by up to 80%. A hybrid approach can also achieve fixation faster and potentially improve acceptability, but may not justify their cost if they require major new investments in suppression technologies. Conclusions Here we demonstrate the value dedicated modelling can provide for interdisciplinary groups of experts when developing TPPs and PPCs. These models could be used by product developers to prioritise and shape development decisions for new Wolbachia replacement products.

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“…Aedes control mainly relies on source reduction, environmental manipulation, and sanitation [34,35]. Notably, laboratory studies on modern vector control technologies are also making their way for the future [36][37][38]. However, our knowledge of the genetic structure of this mosquito species in India is scarce.…”

Section: Introductionmentioning

confidence: 99%

Genetic differentiation among Aedes aegypti populations from different eco-geographical zones of India

Sumitha¹,

Kalimuthu²,

Kumar³

et al. 2023

PLoS Negl Trop Dis

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The present study explicitly evaluated the genetic structure of Aedes aegypti Linn, the vector of dengue, chikungunya, and Zika viruses, across different geo-climatic zones of India and also elucidated the impact of ecological and topographic factors. After data quality checks and removal of samples with excess null alleles, the final analysis was performed on 589 individual samples using 10 microsatellite markers. Overall findings of this study suggested that, Ae. aegypti populations are highly diverse with moderate genetic differentiation between them. Around half of the populations (13 out of 22) formed two genetic clusters roughly associated with geographical regions. The remaining nine populations shared genetic ancestries with either one or both of the clusters. A significant relationship between genetic and geographic distance was observed, indicating isolation by distance. However, spatial autocorrelation analysis predicted the signs of long-distance admixture. Post-hoc environmental association analysis showed that 52.7% of genetic variations were explained by a combination of climatic and topographic factors, with latitude and temperature being the best predictors. This study indicated that though overall genetic differentiation among Ae. aegypti populations across India is moderate (Fst = 0.099), the differences between the populations are developing due to the factors associated with geographic locations. This study improves the understanding of the Ae. aegypti population structure in India that may assist in predicting mosquito movements across the geo-climatic zones, enabling effective control strategies and assessing the risk of disease transmission.

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Elimination of a closed population of the yellow fever mosquito, Aedes aegypti, through releases of self-limiting male mosquitoes

Cited by 4 publications

References 36 publications

The Perpetual Vector Mosquito Threat and Its Eco-Friendly Nemeses

The Perpetual Vector Mosquito Threat and Its Eco-Friendly Nemeses

Using models and maps to inform Target Product Profiles and Preferred Product Characteristics: the example of Wolbachia replacement

Genetic differentiation among Aedes aegypti populations from different eco-geographical zones of India

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