Eleven New Triterpenes from Eurycorymbus cavaleriei

Abstract

Eleven new triterpenes, cavalerols A -K (1 -11, resp.), ten of which were derivatives of hopane and one was derivative of dammarane, were isolated from the twigs of Eurycorymbus cavaleriei. Their structures were elucidated by spectroscopic methods including 2D-NMR analysis. Cavalerol D (4) and cavalerol F (6), cavalerol B (2), and cavalerol G (7) were two pairs of isomers, and silver ion was introduced for their differentiation by multi-stage tandem mass spectrometry. And nine compounds, except 5 and 10, were tested for quinone reductase (QR) induction activities in vitro, and results showed that compounds 2, 4, and 7 exhibited moderate induction activities with CD values of 8.62, 9.13, and 2.56 mg/ml, respectively, and compounds 6 and 8 showed cytotoxicity against hepa 1c1c7 cell line with IC 50 values of no more than 1 mg/ml.

Cytotoxic Norhopene Triterpenoids from the Bark of Exothea paniculata from Abaco Island, Bahamas

“…With a terminal vinyl group at δ H : 5.10, 5.43 ppm, these features suggested a hopene skeleton based on a structure similarity search using the Dictionary of Natural Products [7]. The compound had many similarities in terms of its NMR data to hopene derivatives known as the cavalerols [8]. Five primary, ten secondary, twelve tertiary, and nine quaternary carbon atoms accounted for a total of thirty-six carbon atoms in the molecular formula.…”

Vistriterpenoids A and B, Two New 24‐Nor‐oleanane Triterpenoids from Dodonaea viscosa

“…The known triterpenoids were identified as epifriedelinol (3), [10] cavalerol A (4), [11] [12] olean-12-ene-3β,29diol (5), [13] and 3α-hydroxytirucalla-7,24-dien-21-oic acid (6), [14] respectively. Their spectroscopic data are in consistence with those in the literature.…”

Triterpenoids

“…294 The structure of the 17,29epoxyhopane derivative dicranostigmone 518, from Dicranostigma leptopdoum, was confirmed by X-ray analysis. 102 The structure of mimusopfarnanol, from the stem bark of Mimusops elengi, has been established as 3b-hydroxyfernan-2one 529. 102 The structure of mimusopfarnanol, from the stem bark of Mimusops elengi, has been established as 3b-hydroxyfernan-2one 529.…”