Cytotoxic Norhopene Triterpenoids from the Bark of Exothea paniculata from Abaco Island, Bahamas

Abstract

!Bioactivity-directed preparative chromatography of the cytotoxic crude dichloromethane bark extract of Exothea paniculata has yielded two new cytotoxic norhopene triterpenoids, exotheol A and exotheol B. The structures were determined by nuclear magnetic resonance and high-resolution mass spectrometry and were found to be potently cytotoxic to MCF-7 and 5637 cells in vitro.

Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach

“…ose studies reported − 21.2 kcal/mol [48] and − 57.7 kJ/mol [51] (equivalent to − 13.79 kcal/mol) as a binding energy of ursolic acid with topoisomerase II which is 2.44-and 3.76-fold higher than the present study, respectively; and the possible reason for the difference in binding energy is variations in the protein preparation and docking platform.…”

Cytotoxic and Antileishmanial Components from the Bark Extract of Ruyschia phylladenia from Monteverde, Costa Rica

“…The isolated compounds from R. phylladenia were screened for in-vitro cytotoxicity against MCF-7 (human breast adenocarcinoma), MDA-MB-231, and 5637 (human bladder carcinoma) cell lines using the MTT assay as described previously [11].…”

“…This report presents the isolation and identification of lupeol, betulinic acid, and isofraxidin from a new, here-to-fore uninvestigated plant source and reaffirms the biological activities of these compounds. Cytotoxicity Assay: The isolated compounds from R. phylladenia were screened for in-vitro cytotoxicity against MCF-7 (human breast adenocarcinoma), MDA-MB-231, and 5637 (human bladder carcinoma) cell lines using the MTT assay as described previously [11].…”